Bactoprenol – Knowledge and References

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Biology of microbes

Published in Philip A. Geis, Cosmetic Microbiology, 2006

Synthesis of peptidoglycan. Peptidoglycan consists of long polysaccharide chains made of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG). Pentapeptide chains are attached to the NAM groups. The chains are then attached to each other either directly by the pentapeptide chains (Gram-negative bacteria) or via a pentaglycine bridge (Gram-positive bacteria). During synthesis of this complex cell wall constituent, two key carriers participate: uridine diphosphate (UDP) and bactoprenol. Bactoprenol is a large 55-carbon alcohol that attaches to the NAM by a pyrophosphate. It moves peptidoglycan subunits back and forth through the hydrophobic membrane.

Current developments in lantibiotic discovery for treating Clostridium difficile infection

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Journal Information

Published in Expert Opinion on Drug Discovery, 2019

Stephanie Kate Sandiford

Microbisporicin is produced by Microbispora sp. as two structurally similar polypeptides (A1 and A2) containing two unusual post-translational modifications 5-chloro-tryptophan and mono (in A2) or bis-hydroxylated (in A1) proline. NAI-107 exerts its activity by binding to lipid II and other bactoprenol-bound precursors impairing membrane function thus resulting in bacteriocidal activity [68].