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Copper nanoparticles synthesis optimization using melinjo (Gnetum gnemon L.) leaves extract and beta cyclodextrin as a stabilizer
Published in Ade Gafar Abdullah, Isma Widiaty, Cep Ubad Abdullah, Medical Technology and Environmental Health, 2020
H.A. Wisnuwardhani, R.D. Shafira, Y. Lukmayani, A. Arumsari
Natural antioxidants contained in plants are generally phenolic or polyphenolic compounds which can be in the form of flavonoids, cinnamic acid derivatives, coumarin, tocopherol, and polyfunctional acids. Flavonoids that have antioxidant activity include flavones, flavonoids, flavanones, isoflavones, catechins, and chalcon (Markham 1988).
Carpobrotus edulis L.(Sour Fig): Phytochemistry, Pharmacology, and Toxicology
Published in Megh R. Goyal, Hafiz Ansar Rasul Suleria, Ademola Olabode Ayeleso, T. Jesse Joel, Sujogya Kumar Panda, The Therapeutic Properties of Medicinal Plants, 2019
Francis N. Nkede, Simeon A. Materechera, Wilfred Otang-Mbeng
Ibtissem et al., assessed the antioxidant potential of C. edulis using water extract and the synthetic antioxidant (BHT) was used as standard. High antioxidant activity was observed up to 1mg/ml dose, and DPPH inhibition showed 94.64% ± 0.45% at a dose of 2 mg/ml [6].
Plant-Based Secondary Metabolites for Health Benefits
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Monika Sharma, Jyotsana Dwivedi, Bhanu Kumar, Bramhanand Singh, A. K. S. Rawat
Antioxidants are free radical scavenging molecules, which ensure minimum risk of oxidative damage and other problems associated with the oxidation process. Examples of natural antioxidant molecules having free-radical scavenging activity are carotenoids, tocopherols, ascorbates, lipoic acids, and polyphenols. Food material rich in antioxidant activity are of great significance by virtue of their health benefits.87,97 Many studies on animals have suggested that optimum consumption of whole grains, fruits, especially citrus, and green vegetables help in preventing complications arising due to oxidative stress.50,51 Synthetic antioxidants, such as butylated hydroxyl anisole and butylated hydroxyl toluene play a vital role in the food and drug sector.32,78,103
Morel mushroom, Morchella from Kashmir Himalaya: a potential source of therapeutically useful bioactives that possess free radical scavenging, anti-inflammatory, and arthritic edema-inhibiting activities
Published in Drug and Chemical Toxicology, 2022
Haridas Ramya, Korattuvalappil S. Ravikumar, Zuhara Fathimathu, Kainoor K. Janardhanan, Thekkuttuparambil A. Ajith, Manzoor Ahmad Shah, Ramona Farooq, Zafar A. Reshi
The existence of free radicals and their relevance in pathophysiology of diseases are extensively investigated in recent years. Under normal conditions, healthy body has a balance between free radical and antioxidant defense. When this balance is disturbed, the condition leads to oxidative stress. Oxidative stress can cause injury to biomolecules resulting into numerous ailments including cancer and cardiovascular diseases. Reactive oxygen species (ROS) and increased levels of blood lipid are key to the pathogenesis of atherosclerosis, one of the major cause of mortality in recent years. Antioxidants are major defense against radical-mediated toxicity by protecting damages caused by free radicals and ROS. Protection of biomolecules from ROS-mediated damage by natural products is considered to be promising. Phenolics and flavonoids contents of natural products contribute to the antioxidant activity. Several edible and medicinal mushrooms have been reported to possess significant antioxidant activity (Ajith and Janardhanan 2007). The result of the current experimental studies reveal that morel mushroom, M. elata from Kashmir Himalaya possessed profound free radical scavenging activity. The various solvent extract of this mushroom showed marked DPPH, ABTS, hydroxyl, nitric oxide scavenging, and lipid peroxide-inhibiting activities in vitro.
Anti-Inflammatory Potential Exhibited by Amomum subulatum Fruits Mitigates Experimentally Induced Acute and Chronic Inflammation in Mice: Evaluation of Antioxidant Parameters, Pro-Inflammatory Mediators and HO-1 Pathway
Published in Journal of the American College of Nutrition, 2021
Sudarsanan Drishya, Suresh Sulekha Dhanisha, Chandrashekharan Guruvayoorappan
Studies have reported that different solvent fractions of its fruits exhibited significant antioxidant activity (11, 12), and consumption of such antioxidant rich foods can have beneficial effects on human health (13). Its seeds were reported to contain bioactive compounds like subulin, petunidine-3,5-diglucoside, leucocyanadin-3-O-β-D-glucopyranoside cadamonin and alpinetin (14, 15). The dietary chalcone cardamonin has the potential to be a pharma food as it was reported to possess anticancer, anti-inflammatory, antioxidant, hypoglycemic, vasorelaxant and anti-infectious activities (16). Similarly the flavonoid alpinetin was reported to have anti-inflammatory (17, 18), anticancer (19–21) and vasorelaxant (22) properties. Essential oil fraction is majorly constituted by 1,8-cineole, limonene, sabinene, pinenes and terpinols and it was reported to have anti-inflammatory and antimicrobial activities (23, 24). Based on these findings, it can be hypothesized that A. subulatum has the potential to be a functional food besides its nutritional value. Hence our paramount objective was to assess the anti-inflammatory potential of A. subulatum fruits for its possible use as an alternative therapeutic agent against inflammatory conditions. To the best of our knowledge, this is the first detailed report on anti-inflammatory activity of the crude plant extract.
Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study
Published in Journal of Dermatological Treatment, 2021
Rasoul Shakiba, Mohammad Ali Nilforoushzadeh, Fataneh Hashem-Dabaghian, Bagher Minaii Zangii, Ali Ghobadi, Laila Shirbeigi, Jale Aliasl, Mahdad Shakiba, Roshanak Ghods
In an experimental study evaluated the anti-inflammatory and protective effects of Z. spina-christi fruit extract against acetic acid induced colitis in rats. Their results showed cedar has anti-inflammatory and antioxidant properties (33). In another study the anti-inflammatory activity of Z. spina-christi by electromobility shift assay (EMSA) and Western blot analysis was reported (20). The antioxidant activity might be due to the presence of polyphenols in seed and fruit extracts. The free radical scavenging property of Z. spina-christi may be considered as a mechanism of action of this plant (34). As a result, cedar with anti-inflammatory, antioxidant and antibacterial properties can be effective on acne lesions (23). The study limitations were short term follow up and the small sample size. The strengths of this study were the use of cedar plant as an indigenous and native species in Iran, which is available and inexpensive and did not cause significant complications on topical use. The present study seems to be the first clinical study to examine the topical effects of cedar on acne. Authors suggested that another study with a larger sample size should be done for evaluating the effect of Z. spina-christi on acne vulgaris. There were no serious side effects by cedar solution.