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Gloves
Published in Robert N. Phalen, Howard I. Maibach, Protective Gloves for Occupational Use, 2023
Marie-Noëlle Crépy, Pierre Hoerner
Most of the reusable gloves are laminated with an inner fabric liner made of cotton or synthetic fibers that provide easy donning and comfort and could also improve the cut-resistance performance. Some gloves can also have at their inner surface a flock coating of fibers that create a silky and comfortable touch and provide some additional level of comfort during usage. This flock is composed of finely cut natural or synthetic fibers deposited over the glove substrate with the help of an adhesive, typically an acrylic polymer.
Retention of metal clips in overdentures
Published in J. Belinha, R.M. Natal Jorge, J.C. Reis Campos, Mário A.P. Vaz, João Manuel, R.S. Tavares, Biodental Engineering V, 2019
M.J. Roxo, M. Sampaio-Fernandes, P. Vaz, J.C. Reis Campos, M.H. Figueiral
Because it has a composition less similar to the PMMA blocks where it was placed, unlike MegaCryl, which is an acrylic polymer based on methylmethacrylate, its bonding may not be ideal, leading to the detachment of the Quick-Up® from the block. The mean retentive strength values obtained in the fatigue test for the two materials (33.85 N for MegaCryl N, 49.33 N for Quick-Up®) may also be related to their chemical composition, since the attachment used was always the same type. Quick-Up® may have a larger modulus of elasticity than MegaCryl N and consequently a higher stiffness, requiring greater force for the active part of the clip to exit the bar. It may also be for this reason that in the traction test the clip has been removed with Quick-Up®. However, the materials used should be tested to confirm this reading of the results.
Nanoencapsulation of R-phycoerytrin extracted from Solieria filiformis improves protein stability and enables its biological application as a fluorescent dye
Published in Journal of Microencapsulation, 2023
Jéssica Roberta Pereira Martins, Antonia Livânia Linhares de Aguiar, Karina Alexandre Barros Nogueira, Acrisio José Uchôa Bastos Filho, Thais da Silva Moreira, Márjory Lima Holanda Araújo, Claudia Pessoa, Josimar O. Eloy, Ivanildo José da Silva Junior, Raquel Petrilli
Nanoparticles for protein loading were also reported in different studies. For instance, García-Fuentes using solid triglycerides, encapsulated insulin by the method of double emulsion and solvent evaporation. The nanoparticles had the average particle size of 190–225 nm (Garcı́a-Fuentes et al. 2003). Only nanoparticles prepared with lecithin concentrations below 0.5% were >300 nm. Nanoparticles loaded with two insulins (Actrapid, Novorapid) and two distinct polymers, a biodegradable polyester (poly-ε-caprolactone) and a non-biodegradable polycationic acrylic polymer (Eudragit RS), were synthesised by solvent evaporation preparation and water-in-double emulsification oil-in-water (w/o/w). The zeta potential was positive whenever non-biodegradable polycationic acrylic polymer was part of the nanoparticle matrix. The encapsulation efficiency was ∼96%, except for the Novorapid-loaded poly-ε-caprolactone nanoparticles having an encapsulation of only 35% (Socha et al. 2009). Similar results were observed also in nanoparticles prepared with a mixture of a biodegradable polyester (poly (-ε-caprolactone)) and a non-biodegradable polycationic acrylic polymer (Eudragit RS), resulting in encapsulation efficiency around 96% (Damgé et al. 2007).
Second generation drug-eluting stents: a focus on safety and efficacy of current devices
Published in Expert Review of Cardiovascular Therapy, 2021
Francesco Spione, Salvatore Brugaletta
Everolimus is an immunosuppressive and antiproliferative agent, derived from rapamycin (sirolimus). The everolimus eluting stent (EES) family encloses the Promus® and Promus® ElementTM (Boston Scientific, Natick, MA, USA) stents, and Xience® (Abbot Vascular, Santa Clara, CA, USA) stents (V, Prime. Xpedition, Alpine, Sierra), whose Xience® VTM represents the most widely studied one. Both Xience® VTM and Promus® have a cobalt-chromium platform alloy with a strut thickness of 81 μm, derived from their BMS equivalent, the Multi-Link Vision®. The stent is coated with a durable biocompatible acrylic polymer and fluorinated copolymer releasing everolimus. Eighty percent of everolimus is released during the first month and all the drug within four months [2,9]. The other stents are newer versions of Xience®, utilize same drug and polymer formulation of Xience® VTM/Promus®, with a different design of stent and delivery system that provide greater flexibility and deliverability. The Promus® ElementTM stent, with the same drug and polymer formulation of Xience® VTM/Promus®, had a platinum-chrome platform [10].
Pharmaceutical implants: classification, limitations and therapeutic applications
Published in Pharmaceutical Development and Technology, 2020
Zahra Mohtashami, Zahra Esmaili, Molood Alsadat Vakilinezhad, Ehsan Seyedjafari, Hamid Akbari Javar
The inert nature of non-biodegradable polymers and the simplicity of their processing have fascinated researchers to discover their function in biomedical applications. Over the past decades, many non-biodegradable polymeric devices and implants have been established and successfully used to help millions of patients worldwide (Dash and Cudworth 1998). These systems considered suitable for long- term treatment of chronic diseases as they could release drugs longer than biodegradable ones. The drug release rate could be controlled by the thickness of the permeable membrane and surface area of the drug-containing reservoir. Among all the benefits, the required minor surgery to implant and remove these matrices considered risky for patient’s compliance (Parent et al. 2013). The variety of non-biodegradable polymers have been considered in drug delivery; e.g. polysaccharide derivatives, acrylic polymer derivatives, dextran, polyethylene oxide, polypropylene, silicone rubber (polydimethylsiloxane or PDMS), Ethylene-vinyl acetate (EVA), Vinylidene Fluoride copolymers, thermoplastic polyurethane (TPU) and lectins of plants or microbial origins. The wide range of chemical and physical properties of these polymers could provide flexible characteristics for the designed delivery system from short to long-term release profile and also their ability to load hydrophobic or hydrophilic active material among others.