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Application of Bioresponsive Polymers in Drug Delivery
Published in Deepa H. Patel, Bioresponsive Polymers, 2020
Manisha Lalan, Deepti Jani, Pratiksha Trivedi, Deepa H. Patel
A copolymer of NIPAAm and acrylic acid was developed which had both pH and temperature sensitivity for use in the preparation of matrix drug delivery system. The drug was admixed physically with the developed copolymer. Although this was, a matrix system but it behaved very similar to enteric coating. The system remained intact and insoluble at acidic pH and gradually dissolving at intestinal pH. The developed formulation did not release rapidly in intestine in contrast to enteric-coated tablets, but gave sustained release of drug over an extended period of time. The rate of drug release directly correlated with the amount of acrylic acid [31].
Rheological Additives
Published in Laba Dennis, Rheological Proper ties of Cosmetics and Toiletries, 2017
Polymer of acrylic acid with covalently bound hydrophobic groups. The result is an amphipathic resin that adsorbs at the oil/water interface. This enables the polymer to act as a primary emulsion stabilizer.
Synthetic Polymers in Cosmetics
Published in E. Desmond Goddard, James V. Gruber, Principles of Polymer Science and Technology in Cosmetics and Personal Care, 1999
E. Desmond Goddard, James V. Gruber
The behavior of polymers is also affected by their chemical identities. For instance, if the polymer is actually a copolymer, or if it is cross-linked or hydrophobically modified, variations from typical solution behavior occur. These examples are addressed in this chapter when they become relevant. Simple linear polymers include poly[(meth)acrylic acid], poly(acrylamide), poly(ethylene oxide), polymers and random copolymers of poly(ethylene oxide) and (propylene oxide), poly(vinyl alcohol), and poly(vinylpyrrolidone). Such polymers primarily influence solution viscosity through random chain entanglement. However, all of these polymers possess functional sites, which allows them to bind interpolymerically and aids in chain entanglement. These functional sites also allow all of these polymers to dissolve in highly polar aqueous mediums under the right conditions. We will focus on these polymers initially. Poly meth) acrylic Acid. Poly(acrylic acid) (PAA) is a workhorse polymer for cosmetic thickening However, in cosmetic applications this polymer is typically either cross-linked or hydrophobically modified; these altered forms of PAA will be addressed in later sections. Poly(methacrylic acid) (PMA) has found significantly fewer ap-
Microneedles for transdermal drug delivery using clay-based composites
Published in Expert Opinion on Drug Delivery, 2022
Farzaneh Sabbagh, Beom Soo Kim
Carboxymethylcellulose (CMC) is a type of cellulose derivative in which a carboxymethyl group (-CH2-COOR) is bonded to a part of the hydroxyl group present in the cellulose skeleton [92]. Polar carboxyl groups make cellulose chemically reactive, soluble, and hydrophilic. However, the main disadvantage of natural polymer-based hydrogels is poor mechanical properties due to large swelling [93]. Attempts have been made to overcome these problems by using various types of grafting, developing interpenetrating polymer networks and nanofillers, or altering the structure by physically mixing with other polymers. Poly (acrylic acid) is a hydrophilic polymer due to the presence of hydrophilic -COOH groups and can absorb huge amounts of water. Therefore, poly(acrylic acid) is widely used in drug delivery systems [67].
Effect of substitution of plasticizer dibutyl phthalate with dibutyl sebacate on Eudragit® RS30D drug release rate control
Published in Pharmaceutical Development and Technology, 2019
Rakesh Singh Chaudhary, Tejas Patel, Job Richard Kumar, Mohamed Chan
Acrylic Acid polymers are widely used in the film coating of pharmaceutical dosage forms for a variety of functional and non-functional usage, e.g. moisture protection, gastric acid resistance, taste masking, and to control the drug release in the controlled release dosage form. For controlling the drug release by barrier film formed on the dosage form consists of film forming polymer, insoluble fillers such as colors, opacifiers, plasticizers, and solvent. For the controlled release dosage form, where the drug release is controlled by the polymer film, use of methacrylic acid derivative is often used. The presence of plasticize in film coating formulations has an important role in providing increased elasticity and flexibility to the film formed (Godwin 2000). The use of plasticizer in polymeric solution or dispersions for film coating allows to increase the workability, flexibility, and reduced tensile strength of the polymer by modifying thermal and mechanical properties of the polymer (Rowe et al. 1984; Bodmeier and Paeratakul 1994). The plasticizers in polymeric dispersion during plasticization, partition into and soften the colloidal polymeric particles and promote particle deformation to enable coalescence into a homogenous film. The plasticization effect is dependent on the plasticizer–polymer compatibility and the plasticizer performance in the film during coating, storage, and during contact with artificial or biological fluids.
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis
Published in Pharmaceutical Development and Technology, 2023
Rafaela Said dos Santos, Jéssica Bassi da Silva, Camila Felix Vecchi, Katieli da Silva Souza Campanholi, Hélen Cassia Rosseto, Mariana Carla de Oliveira, Francielle Pelegrin Garcia, Rodolfo Bento Balbinot, Lidiane Vizioli de Castro Hoshino, Tânia Ueda Nakamura, Celso Vataru Nakamura, Mauro Luciano Baesso, Wilker Caetano, Marcos Luciano Bruschi
The effects of poly(acrylic acid) derivative types (C934P, C974P, PC) were statistically compared by analysis of variance (ANOVA). In all cases, individual differences between means were identified using Tukey’s Honestly Significant Difference test. In all tests, a value of p < 0.05 was utilized to denote significance, and the Statistica software version 10.0 (StatSoft Company, Tulsa, OK, USA) was used throughout.