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Clinical pharmacology: traditional NSAIDs and selective COX-2 inhibitors
Published in Pamela E Macintyre, Suellen M Walker, David J Rowbotham, Clinical Pain Management, 2008
Stephen F Jones, Aidan M O’Donnell
Indometacin is a methylated indole derivative with a halflife of 4.5–6 hours. It is recommended for the treatment of arthritis and gout, although has too many side effects to be used as the NSAID of first choice for analgesia (with the exception of some topical preparations). CNS symptoms are frequent and include headaches, dizziness, and depression. Its use in acute gout and dysmenorrhea is well tolerated because the duration of treatment is limited to a few days. Acemetacin is the glycolic acid ester of indometacin.100
Preparation and in vitro–in vivo evaluation of QbD based acemetacin loaded transdermal patch formulations for rheumatic diseases
Published in Pharmaceutical Development and Technology, 2022
Ece Özcan Bülbül, Hasan Ali Husseın, Gizem Yeğen, Mehmet Evren Okur, Neslihan Üstündağ Okur, Neşe Buket Aksu
Acemetacin is an anti-inflammatory and non-steroidal drug (NSAID) used for rheumatic diseases. The daily dosage of acemetacin is 120 mg p.o. (can be increased to 180 mg) and plasma half-life of 1–2 h. The most common adverse effects are peptic ulceration or gastrointestinal bleeding (Chandrasekharan 2007). Orally administered anti-inflammatory non-steroidal drugs also cause side effects like vomiting, nausea, abdominal pain, dizziness, heartburn, and headache (Amodwala et al. 2017). The most frequent indications are chronic articular rheumatism, psoriatic arthritis, and acute inflammatory events in degenerative arthropathies. Nowadays, capsule (extended-release, delayed-release, and coated) dosage form is available. However, a transdermal system can help overcome the adverse effects (Li et al. 2005). By preparing the transdermal system of acetametacin, it is aimed at circulating at a certain speed and delivering the drug through the skin in a controlled manner. In addition, TDDS was preferred over the oral route because it has advantages, including increased patient compliance and avoidance of first-pass metabolism (Sabbagh and Kim 2022).
Cross-sectional study of patient satisfaction with oral analgesics in patients with chronic pain in Japan
Published in Expert Opinion on Pharmacotherapy, 2020
Takahiro Ushida, Teruyoshi Inoue, Daiju Matsui, Mizuka Yokoyama, Kazuhito Shiosakai, Kuniyuki Takeda, Katsushi Fukuoka, Osamu Nakagawa, Kaoru Okuizumi
Acemetacin, amfenac sodium, ampiroxicam, aspirin, aspirin dialuminate combination, celecoxib, diclofenac, etodolac, flufenamate aluminum, flurbiprofen, ibuprofen, indomethacin farnesyl, lornoxicam, loxoprofen, mefenamic acid, mofezolac, meloxicam, nabumetone, naproxen, oxaprozin, proglumetacin, sulindac, tiaprofenic acid, tiaramide, and zaltoprofen