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Mitigation of Obesity: A Phytotherapeutic Approach
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
A.B. Sharangi, Suddhasuchi Das
Aloe vera belongs to the family Liliaceae. The major chemical composition of A. vera includes phytosterols, anthraquinones, chromones, enzymes, tannins, amino acids, proteins, vitamins, pectins, hemicelluloses, glucomannan, acemannan, and mannose derivatives (Misawa et al., 2012a). A. vera gel powder in Sprague-Dawley rats with diet-induced obesity decreased body weight (Misawa et al., 2012a). Misawa et al. (2012b) reported that feeding of A. vera to Zucker diabetic fatty rats which produces lophenol and cycloartenol (two types of phytosterol), significantly reduced visceral fat weights. Stimulation of energy expenditure is one of the proposed anti-obesity mechanisms of A. vera (Misawa et al., 2012a), other mechanism being the regulation of expression levels of hepatic genes encoding to lipogenic enzymes (ACC, FAS), and transcriptor factor SREBP-1, which, by the administration of aloe sterols, is found to be decreased drastically; and to the increased of hepatic β-oxidation enzymes ACO, CPT1, PPARα (Misawa et al., 2012b).
Role of Aloe vera in Irritable Bowel Disease
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Dilipkumar Pal, Souvik Mukherjee
Aloe vera contains about 200 potentially chemical constituents, such as vitamins, enzymes, minerals, sugars, lignin, saponins, salicylic acids, and amino acids. Phytochemicals in aloe species are13–16,64–70: 3-furanmethanol,Acemannan,Aloe-emodin,Aloechrysone,Aloeride,Aloesaponol,Aloetic acid,Alosone,oxylipin,Anthracene compounds and their derivatives,Anthraquinones,babaloin,Chrysamminic acid,Chrysophanic acid,Cinnamic acids and their derivatives,Dihydro-coumarone,Ethyl chromones,• Feroxidin,Flavonoids,Flavonoids,Galacturonic acid,Homonataloin,Iso-babaloin,Isoxanthorin,Laccaic acid,Nataloe emodin,Nataloe-emodin-2-O-glucosidePlicataloside,Pluridone,Saponin, etc.
Topical and oral applications of Aloe vera improve healing of deep second-degree burns in rats via modulation of growth factors
Published in Biomarkers, 2022
Ayman Atiba, Walied Abdo, Ehab Ali, Marwa Abd-Elsalam, Mohamed Amer, Ahmed Abdel Monsef, Reda Taha, Samar Antar, Ayman Mahmoud
Aloe vera (A. vera) is a drought-resistant, stemless succulent plant from the Lily family. It is native to hot climates and has been utilised medicinally by different cultures, including the Egyptian, Indian, Chinese, and European cultures for about five thousand years (Pol et al. 2016). A. vera gel is a mucilaginous gummy aqueous extract that has been shown to exert anti-inflammatory, antioxidant, immunoboosting, anti-cancer, healing-promoting, anti-aging, and anti-diabetic efficacies (Ray and Ghosh 2014). Aloe species have been used as a traditional medicine for a long time. It has been rolled out for the treatment of a variety of inflammatory digestive and skin ailments, including inflammatory bowel disease (Radha and Laxmipriya 2015, Sherafatmanesh and Ekramzadeh 2018). For many centuries, A. vera has been used as a hold house remedy for burns, and several recent studies have investigated its efficacy in greater depth (Qadir 2009, Hekmatpou et al. 2019). Aloe gel is a rich source of polysaccharides of which mannose-6-phosphate and acemannan are the major constituents responsible for its immunomodulatory and antitumor activities (Gao et al. 2019). Recently, It is re-emerging as a viable treatment to counteract infection in open wounds, and chronic ulcers (Hekmatpou et al. 2019). The purpose of our study was to evaluate the effect of oral and topical administration of A. vera on cutaneous wound healing induced by deep second-degree burn, focussing on wound closure, and antioxidant and growth factors in normal rats.
The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage
Published in Toxicology Mechanisms and Methods, 2022
A. Wallace Hayes, Roger A. Clemens, Peter Pressman
Aloe vera is one of more than 400 species of the genus Aloe. Aloe vera specifically refers to the Aloe barbadensis Miller plant, which is the most common species used in Aloe-based products. The global Aloe vera market was valued at between USD 600 million and 1.60 billion in 2018 and is anticipated to expand at a compound annual growth rate of between 7.6% and 8.5% (https://www.grandviewresearch.com/industry-analysis/aloe-vera-extracts-market). Growing awareness regarding the putative medicinal importance of Aloe vera in the management of various pathologies has increased the demand for Aloe vera extracts in natural and organic cosmetics, dietary supplements, beverages, and other consumer products (Pressman et al. 2019). One of the major trends seen in the global market is the increasing use of Aloe vera extracts in sugar-free drinks. Development in this space is expected to contribute to new formulations and novel products in the global food markets. However, the range of aloe-containing products is not alike, and there is significant diversity in terms of the chemical composition, especially regarding the hydroxyanthracene derivative (HAD) content, depending on the portion of the plant used, the method of extraction, preparation, and processing used in the manufacturing of these products. Salient for the present study is the fact that the inner leaf of the Aloe vera plant consists of aqueous parenchyma, from which the gel may be collected. In addition to water, the Aloe vera gel contains various polysaccharides, notably acemannan. This compound has been associated with an array of health-promoting properties supported by both in vitro and in vivo studies (Im et al. 2010; Kumar and Tiku 2016; Quezada et al. 2017).
Efficacy of Aloe-Vera Use for Prevention of Chemotherapy-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Controlled Clinical Trial
Published in Comprehensive Child and Adolescent Nursing, 2021
Muaaz Alkhouli, Mohannad Laflouf, Mazen Alhaddad
Hyaluronic acid, heparin, and acemannan are the main mucopolysaccharides found in aloe-vera. However, among them, acemannan is the most abundant. It activates macrophages that bind and destroy microorganisms (Ray & Aswatha, 2013). Nevertheless, hyaluronic acid plays an important role in collagen synthesis and fibroblast activity (Chithra, Sajithlal, & Chandrakasan, 1998).