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Anti-Proliferative Properties of Various South African Buddleja Species
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Buddlejone, which is an abietane diterpene, has been isolated from the root bark of B. albiflora Hemsl. After the first report of this compound present in the Buddleja genus, it was also isolated from the roots of B. globosa and in the bark of B. yunanensis (Houghton et al., 1996; Liao et al., 1999; Mensah et al., 2000). Maytenone was isolated from the roots and bark of B. globosa (Mensah et al., 2000). There is a considerable amount of non-cyclic crocetin-gentiobiose ester present in the flowers of B. officinalis Maxim., which is used as a yellow colorant in foods and is predicted to be responsible for the intense yellow color of the inner surface of the corollar tube in the flowers of various Buddleja species (Liao et al., 1999; Aoki, 2001; Houghton et al., 2003). Buddlejone, deoxybuddlejone and maytenone exhibited antifungal activity, but it was considerably less than that of sesquiterpenes (Mensah et al., 2000).
Tanshinone Diterpenes
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Mohamed-Elamir F. Hegazy, Tarik A. Mohamed, Abdelsamed I. Elshamy, Ahmed R. Hamed, Sara Abdelfatah, Soleiman E. Helaly, Nahla S. Abdel-Azim, Khaled A. Shams, Abdel-Razik H. Farrag, Abdessamad Debbab, Tahia K. Mohamed, El-Seedi Hesham R., Mohamed E.M. Saeed, Masaaki Noji, Akemi Umeyama, Paul W. Paré, Thomas Efferth
Tanshinone was tested for tyrosine phosphorylation activity with the insulin receptor (IR) β-subunit and in 3T3-L1 adipocytes (Jung et al. 2009). These diterpenes can serve as leads for specific IR activators for diabetes (Nagarajan and Brindha 2012). Abietane-type diterpene metabolites isotanshinone IIA, dihydro-isotanshinone I and isocryptotanshinone obtained through bioassay guided fractionation exerted non-competitive PTP1B inhibition (Han et al. 2005). Different mechanisms of action for isotanshinone antidiabetic activity were evaluated by Nagarajan and Brindha (2012).
Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
The abietane diterpene 15-dehydrocyrtophyllone A isolated from the roots of Clerodendrum bungei Steud. inhibited angiotensin-converting enzyme with an IC50 of 42.7 µM (captopril: IC50 of 13.3 µM).312
Screening the dermatological potential of Plectranthus species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Joana M. Andrade, Eva María Domínguez-Martín, Marisa Nicolai, Célia Faustino, Luís Monteiro Rodrigues, Patrícia Rijo
The Plectranthus spp. extracts and isolated compounds have been evaluated as tyrosinase inhibitors. The organic extracts showed promising results (Figure 4(A)) with inhibitory activity as high as 68% compared to 92.9 7.4% obtained for kojic acid used as positive control. According to the results obtained (Figure 4(A)), the methanolic (25–66%) and acetonic (27–68%) extracts exhibited the highest tyrosinase inhibition activity (p < 0.05). High tyrosinase inhibition was observed for the P. grandidentatus acetonic (67.9 3.6%), P. ecklonii methanolic (65.9 3.4%) and P. saccatus acetonic (56.4 5.7%) extracts. Moreover, P. grandidentatus and P. ecklonii showed the highest anti-tyrosinase activity in vitro, and these were also the plants that showed increased antioxidant activity. The observed results can be attributed to the abietane diterpenoids mainly present in the organic extracts of these two plants23,33.
Study of the mechanism of action, molecular docking, and dynamics of anticancer terpenoids from Salvia lachnocalyx
Published in Journal of Receptors and Signal Transduction, 2020
Hossein Hadavand Mirzaei, Amir Reza Jassbi, Somayeh Pirhadi, Omidreza Firuzi
Further literature survey shows that induction of apoptosis is one of the mechanisms suggested to be involved in the anticancer effect of isolated terpenoids in several cancer cells [25,26]. Taxodione, ferruginol, and 6-hydroxysalvinolone with abietane diterpenoid skeleton caused cancer cell death by apoptosis induction as shown by DNA fragmentation, increased cells in sub-G1 phase, expression of the pro-apoptotic protein Bax, cleaved caspase-3, and cleaved PARP [27]. Moreover, Burmistrova and colleagues have evaluated the induction of apoptosis by four abietane diterpenoids including taxodone, 7α-acetoxy-6β-benzoyloxy-12-O-benzoylroyleanone, 7α-acetoxy-6β-hydroxy-12-O-(4-methoxy)benzoylroyleanone, and 7α-acetoxy-6β-hydroxy-12-O-(4-chloro) benzoylroyleanone in HL-60 cells. The results showed that apoptosis induction in human leukemia cells was triggered by the release of mitochondrial proteins, including cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor), and also accompanied by dissipation of the mitochondrial membrane potential (ΔΨ). Their findings also showed that the induction of apoptosis by these compounds was independent of ROS generation [28]. Another study has demonstrated that ketoethiopinone and ortho-diacetate aethiopinone inhibit the proliferation of the MCF-7 cells by inducing apoptosis and DNA fragmentation [29]. Finally, sclareol, with a labdane type diterpenoid structure, has shown to induce apoptosis in osteosarcoma cells through both loss of mitochondrial membrane potential and G1 cell cycle arrest [30].