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Osteoid Osteoma
Published in Kelechi Eseonu, Nicolas Beresford-Cleary, Spine Surgery Vivas for the FRCS (Tr & Orth), 2022
Kelechi Eseonu, Nicolas Beresford-Cleary
The main differential diagnosis is osteoblastoma, which may be indistinguishable from osteoid osteoma at radiologic imaging. The lesion size and natural history are its main differentiating features: Osteoblastoma tends to be larger (nidus diameter >2cm) and exhibit growth progression on serial imaging.
Benign tumors
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Histopathology reveals a sharply delineated central growth area, the nidus, consisting of a meshwork of trabeculae of osteoid with a variable degree of calcification and surrounded by plump osteoblasts that are dispersed in a very vascular connective tissue usually without any sign of inflammation.252 Osteoblastoma is histologically almost identical to osteoid osteoma, but it lacks the characteristic pain, the nidus is larger, and the rim of reactive sclerotic bone formation is lacking. The differential diagnosis of osteoblastoma and well differentiated osteosarcoma can pose extreme difficulties.253
Bone, Muscle, and Tooth
Published in Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath, Page R. Bouchard, Toxicologic Pathology, 2018
John L. Vahle, Joel R. Leininger, Philip H. Long, D. Greg Hall, Heinrich Ernst
Osteoblastoma is a well-characterized benign bone tumor in humans but, in toxicity studies, has been reported only in association with administration of bone anabolic agents (Vahle et al. 2002; Jolette et al. 2006). Microscopically, the lesion is characterized by an intramedullary pattern of disorganized trabeculae of immature bone, often accompanied by a fibrovascular stroma. There are typically moderate numbers of large, well-differentiated osteoblasts arranged along trabecular surfaces. There is typically minimal cytologic atypia, and low numbers of mitotic figures may be present. In studies where osteoblastoma has been observed, the lesion was often first recognized at a lower magnification as a focus of disorganized trabeculae.
Paediatric fronto-orbital osteoblastoma: case report
Published in Orbit, 2022
David S. Curragh, Nicholas Manton, James Slattery, Dinesh Selva
Osteoblastoma is a rare benign bone tumour which uncommonly involves the orbit.3 The clinical presentation is usually due to growth of the lesion causing a mass effect or pain. Patients can present with proptosis, diplopia, or reduced vision. The symptoms are usually present for a prolonged period of time due to slow growth of the lesion but symptoms can appear over a much shorter period of time suggesting rapid growth. This unusually rapid onset is more suggestive of an inflammatory or malignant pathology, but in the context of osteoblastoma, is more commonly seen in younger patients and has been reported as developing as rapidly as two weeks.8,9
Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum: A case report
Published in Modern Rheumatology, 2018
Kimitaka Nakamura, Masanobu Ohishi, Tomoya Matsunobu, Yasuharu Nakashima, Akio Sakamoto, Akira Maekawa, Yoshinao Oda, Yukihide Iwamoto
Tumors that are responsible for TIO include PMT, GCT, fibrous dysplasia, osteosarcoma, and so on [8–10]. Based on histopathology, Weidner et al. subdivided PMTs into four categories: (i) phosphaturic mesenchymal tumor mixed connective tissue (PMTMCT) variant, (ii) osteoblastoma-like variant, (iii) non-ossifying fibroma-like variant, and (iv) ossifying fibroma-like variant [8]. The majority of FGF-23-producing tumors responsible for TIO are considered to be of the PMTMCT variant [11]. Jiang et al. reported that 46% of the tumors responsible for TIO were PMTMCT [10].