Neuroectodermal neoplasm

Wilms’ Tumor

Published in Victor A. Bernstam, Pocket Guide to GENE LEVEL DIAGNOSTICS in Clinical Practice, 2019

Extensive overexpression of the N-myc gene without amplification, similar to that in neuroblastoma, is characteristic of WT. For example, in the case of an unusual small round cell tumor arising from a fallopian tube in a 15-year-old girl histological studies failed to distinguish WT from a neuroectodermal neoplasm. N-myc, however, proved to be overexpressed in the tumor, but not in normal tissues; this was not due to amplification of the gene, favoring the diagnosis of WT.

Optimum treatment for primary intracranial Ewing sarcoma

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Journal Information

Published in Baylor University Medical Center Proceedings, 2020

Sasha G. Howell, Kristopher A. Lyon, David Garrett, Jason H. Huang, Ekokobe Fonkem

Ewing sarcoma (ES) is an aggressive neuroectodermal neoplasm that frequently manifests in children and young adults. ES tumors without osseous involvement are currently classified as extraosseous ES and were previously designated as primitive neuroectodermal tumors, World Health Organization grade IV.1,2 Histopathological identification of extraosseous ES tumors relies on the presence of a balanced translocation involving chromosomes 11 and 22 or 21 and 22. Extraosseous ES cells characteristically display dense expression of gene product MIC-2 membrane protein (CD99).3 Approaches to the chemotherapeutic treatment, radiation, and overall prognosis are thought to differ greatly between extraosseous ES and other embryonal tumors.4 Here we present a case of adult extraosseous ES arising from the pineal region with third and fourth ventricular invasion and evidence of leptomeningeal spread.

Neuroectodermal neoplasm

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Wilms’ Tumor

Optimum treatment for primary intracranial Ewing sarcoma