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Benign and Malignant Disease of the Oral Cavity
Published in R James A England, Eamon Shamil, Rajeev Mathew, Manohar Bance, Pavol Surda, Jemy Jose, Omar Hilmi, Adam J Donne, Scott-Brown's Essential Otorhinolaryngology, 2022
Orofacial granulomatosis—features of Crohn's disease but no GI disorder. Likely immunological. Exclusion diet initially (e.g. benzoate, sorbate, cinnamon, and chocolate). Systemic immunotherapy occasionally required.
Monographs of essential oils that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
A patient developed allergic contact dermatitis from peppermint oil and its main component menthol in a transdermal therapeutic system (15). Three patients with allergic contact dermatitis from peppermint oil were seen in Japan (article not read); the allergens were menthol (the main component of peppermint oil), piperitone and pulegone (28). Both piperitone and pulegone have been found in a maximum concentration of 5.4% in commercial peppermint oils (55). One individual had orofacial granulomatosis, mainly of the lower lip; he was allergic to peppermint oil and menthol. An exclusion diet resulted in reduction of the swelling; upon re-exposure to menthol, further episodes of lip swelling occurred (30). One positive patch test reaction to peppermint oil was observed in a group of in 53 women with chronic anogenital dermatitis and was considered to be relevant (38).
Benign Oral and Dental Disease
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Konrad S. Staines, Alexander Crighton
Mucosal swellings can also arise as part of systemic disease including CD/orofacial granulomatosis, sarcoidosis, Wegener’s granulomatosis and amyloidosis. Recurrent lip swelling is found in angio-oedema and orofacial granulomatosis.
Altered body composition profiles in young adults with childhood-onset inflammatory bowel disease
Published in Scandinavian Journal of Gastroenterology, 2020
Gudmundur Vignir Sigurdsson, Susanne Schmidt, Dan Mellström, Claes Ohlsson, Magnus Karlsson, Mattias Lorentzon, Robert Saalman
This study included 94 young adult patients with childhood-onset IBD. In total, 65 patients had ulcerative colitis and 29 had Crohn’s disease. The gender distribution was 64 males and 30 females with a median age of 21.8 (18.3–27.7) years and with a disease duration of 10.4 (3.1–21.7) years. A total of 91 patients had a median follow-up time of 7.7 [2–12] years, whereas three patients had only one measurement performed and in these cases only in young adulthood. Most of the patients were currently being treated with or had previously received prednisolone (93%, N = 87) and 5-ASA (99%, N = 93). The corresponding figures for azathioprine and biologics were 70% (N = 66) and 17% (N = 16). One-fourth of the patients had undergone surgery due to IBD (26%, N = 24). In total, 26 patients (28%) had comorbidities. Ten patients had a clinical history of primary sclerosing cholangitis, two of whom had undergone liver transplantation. Other comorbidities included: celiac disease (n = 6), thyroid dysfunction (n = 3), autoimmune hepatitis (n = 3), orofacial granulomatosis (n = 3), and type 1 diabetes (n = 1).
A 30-year follow-up study of patients with Melkersson–Rosenthal syndrome shows an association to inflammatory bowel disease
Published in Annals of Medicine, 2019
Anu Haaramo, Kaija-Leena Kolho, Anne Pitkäranta, Mervi Kanerva
Orofacial granulomatosis (OFG) is a rare inflammatory disease of the mouth and orofacial area. Primary symptoms are oedema of the lips and face, and ulceration in the mouth [5,6]. Patients with OFG may develop a symptomatic intestinal disease like Crohn’s disease (CD), and patients with CD may develop oral lesions [7,8]. As such, clinicians have debated whether OFG is an oral manifestation of CD or a separate inflammatory disorder [9–11]. Histologically characteristic are non-caseating granulomas [5,12,13], similar to those found in MRS.