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Optic Neuropathies Associated with Systemic Disorders And Radiation-Induced Optic Neuropathy
Published in Vivek Lal, A Clinical Approach to Neuro-Ophthalmic Disorders, 2023
Behçet's syndrome is an autoimmune, inflammatory condition of uncertain etiology characterized by recurrent orogenital ulceration, skin lesions, arthropathy and colitis (21–23). The incidence and prevalence of Behçet's syndrome are highest in the Middle East and Asia (22). There is no evidence of a gender predilection with respect to the neurological manifestations of this disease (22). The ocular features of Behçet's include uveitis and vaso-occlusive retinal vasculitis (21). Optic nerve injury may arise from primary inflammatory infiltration of the optic nerve, spread of inflammation into the nerve from an adjacent meningitis, compression of the nerve by an inflammatory mass, raised intracranial pressure, uveitic glaucoma, or contiguous spread from adjacent retinal vasculitis (21–23).
Introduction to Glaucoma
Published in Neil T. Choplin, Carlo E. Traverso, Atlas of Glaucoma, 2014
Neil T. Choplin, Carlo E. Traverso
The differing manifestations of glaucoma are reflected in the clinical examination findings, which can range from the normal-appearing anterior segment of the POAG patient to the markedly abnormal findings in the patient with uveitic glaucoma or iridocorneal endothelial syndrome (ICE). (Consider the appearance of the eye of a patient with Rieger’s syndrome shown in Figure 1.2.) Intraocular pressure may be quite elevated, as in the case of acute angle closure, or well within the “average” range. The visual field examination of the glaucoma patient may likewise represent a spectrum of findings (Chapter 8). At one extreme is the mild diffuse loss of early POAG, and the patient with advanced normal tension glaucoma (NTG) may demonstrate focal defects, which are deep and close to fixation. Evidence of structural damage to the optic nerve or dysfunction of the retinal nerve fibers will usually precede the functional damage seen in the visual field and may sometimes be detectable by newer diagnostic modalities (Chapter 7).
Current profile of secondary glaucoma in a Northern India tertiary eye care hospital
Published in Ophthalmic Epidemiology, 2019
Suneeta Dubey, Kanika Jain, Saptarishi Mukherjee, Neha Sharma, Julie Pegu, Monica Gandhi, Madhu Bhoot
Incidence of aphakic glaucoma was found to be low (2.62%) in our study. This might suggest advancements in cataract surgical techniques as well as better management of postoperative complications. Keratoplasty was found to be an important cause of secondary glaucoma in our study. This might be due to increasing number of keratoplasties being performed at our tertiary eye care institute. This also highlights the importance of regular assessment of post-keratoplasty patients for glaucoma to prevent irreversible visual loss and also graft rejection in these cases. SIG was an important cause of visual morbidity among children and young adults suggesting that there is an over-the-counter prescription of steroids for common ocular ailments such as allergic/vernal conjunctivitis as seen in 90% eyes in our study. The most common cause associated with uveitic glaucoma was recurrent anterior uveitis (80% of the eyes).
The Effect of Topical Ganciclovir and Corticosteroid on Cytomegalovirus Corneal Endotheliitis in Korean Patients
Published in Ocular Immunology and Inflammation, 2019
Je-Hyung Hwang, Minji Ha, Yooyeon Park, So-Hyang Chung
This retrospective study was conducted at the Department of Ophthalmology at the Seoul St. Mary’s Hospital of the Catholic University of Korea in Seoul, Korea. The study protocol was approved by Seoul St. Mary’s Hospital institutional review board, and was conducted according to the Declaration of Helsinki. This study included nine men and four women, all of whom were Koreans, with a mean age of the 64.9 ± 17.7 years, ranging from 35 to 78 years. The mean follow-up duration was 24.5 ± 8.2 months, ranging from 13 to 40 months. Thirteen eyes from the 13 patients with were included, and followed-up for more than 1 year, with continuation of maintenance therapy. Patients with immunodeficiency and CMV retinitis were excluded. Uveitic glaucoma had been diagnosed as a result directly or indirectly from non-infectious inflammation by a glaucoma specialist.
Efficacy and Safety of High-Energy Selective Laser Trabeculoplasty for Steroid-Induced Glaucoma in Patients with Quiescent Uveitis
Published in Ocular Immunology and Inflammation, 2021
Junyan Xiao, Chan Zhao, Anyi Liang, Meifen Zhang, Gangwei Cheng
Glaucoma in uveitis patients has been a great challenge for both uveitis and glaucoma specialists. While IOP-lowering medications have been the mainstay treatments for uveitic glaucoma, refractory cases unresponsive to maximal medical treatment are not uncommon. Surgical treatment of uveitic glaucoma, however, is associated with a high risk of anterior chamber shallowing as well as ocular fundus complications; and in the long term, has a high probability of failure because uveitis commonly affects young people and is usually characterized by a prolonged and fluctuating course of intraocular inflammation. Therefore, there has been a continuing effort to develop less invasive non-surgical treatment modalities for uveitic glaucoma.