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Inflammatory, Hypersensitivity and Immune Lung Diseases, including Parasitic Diseases.
Published in Fred W Wright, Radiology of the Chest and Related Conditions, 2022
Patients with fibrosing alveolitis type changes in association with collagen diseases (e.g. systemic sclerosis) appear to have a better prognosis, and although they may look pathologically and radiologically similar, they have a different biological behaviour, with only about a quarter of the mortality seen with fibrosing alveolitis per se. However patients with systemic sclerosis + pulmonary hypertension tend to die more quickly (these also tend to lose their normal anterior/posterior density gradient on CT).
Laboratory Diagnostic Tests in the Evaluation of Fever
Published in Benedict Isaac, Serge Kernbaum, Michael Burke, Unexplained Fever, 2019
Larson et al. found that antinuclear antibody tests are of little value, except in excluding certain diagnoses. Paradoxically, the ease of obtaining ANA and rheumatoid factor tests allows identification of collagen disease in patients before it evolves into unexplained fever or FUO.1
The Efficacy And Safety Of Mmect – Patient Parameters
Published in Barry M. Maletzky, C. Conrad Carter, James L. Fling, Multiple-Monitored Electroconvulsive Therapy, 2019
No patients with brain tumor were treated. However, three patients were treated who had suffered severe CNS trauma between 1 and 14 years pre-ECT; there were no adverse effects. Also, three patients with systemic collagen diseases were treated without unusual effect.185 Of particular interest was the treatment of seven patients with depression and Parkinson’s disease. All improved in mood, and four of the seven showed a concomitant improvement in their Parkinsonian symptoms, a finding noted elsewhere.45,173,174 No case of tardive dyskinesia was treated. Three pregnant women were treated with MMECT, based upon the reports of its safety to mother and fetus.42 All three women showed marked improvement in mood and, at follow-up, no fetal damage was detected at delivery or one year thereafter. No unusual adverse effects occurred in the treatment of the other assorted concomitant conditions, such as glaucoma and hepatic or renal disease. Although reports have appeared indicating a hyperglycemic effect of ECT in diabetics,51a we saw no blood glucose elevations among the 14 diabetic patients treated with MMECT in our series. Among six patients treated with grand mal epilepsy, no cases of aggravation of spontaneous seizures were seen.
Blood-based biomarkers of chronic inflammation
Published in Expert Review of Molecular Diagnostics, 2023
As the twentieth century progressed, inflammation was seen to involve reactions, both extracellularly within the connective tissue matrix, and intracellularly within adjacent local parenchymal cells. The sequence of these reactions came to be described in exquisite biochemical and cell physiologic detail with specific adaptations for particular tissues [9]. Notably, in some conditions, inflammation occurred entirely within connective tissues only, giving rise to the concept of ‘collagen diseases’ [18,19]. Less well recognized because historically inflammation was associated with blood vessel congestion (redness), and increased permeability, components of inflammation, particularly edema and cellular reaction (secretion of proteoglycan), could occur in avascular connective tissues such as cartilage, and enthesis. These components are particularly prominent in the chronic inflammatory disease, ankylosing spondylitis, now termed with an expanded definition, axial spondyloarthritis [20–24].
A case of adenoviral covid-19 vector vaccine possibly linked to severe but reversible interstitial lung injury post-vaccination
Published in Infectious Diseases, 2022
George D. Liatsos, Andreas Mavroudis, Panayiotis Iliakis, Maria Karmpalioti, Emmanouil Koullias, Dimitrios Vassilopoulos
A non-identified infectious pathogen could have been responsible for patient’s respiratory failure. Since severe deterioration of his clinical picture occurred, a wide spectrum empirical coverage for common and atypical bacteria, fungal infections and pneumocystis jirovecii was administered, not actually based on some scientific evidence but mostly reflecting physicians’ anguish for the patient’s undiagnosed, unknown, life-threatening disease. In any case, wide-spectrum antibiotics were administered for five days only, as pulsed steroids showed a dramatic improvement, therefore such a short duration regimen would be inadequate to treat any possible severe infection. Subsequently, antibiotic coverage was shifted to ceftriaxone plus doxycycline, mostly as prophylaxis for possible secondary infections due to the high dose steroids administered. In addition, extended laboratory work-up excluded most of the potential infectious agents that could have been responsible for such clinical syndrome (shown in Table 1). Collagen diseases with pulmonary involvement were placed low in the differential diagnosis list. Even if the patient suffered such a disease, it would have probably recurred after discontinuation of the short-term steroid scheme administered, in the absence of any other immunosuppressive medication.
Clinical phenotypes and genetic analyses for diagnosis of systemic autoinflammatory diseases in adult patients with unexplained fever
Published in Modern Rheumatology, 2021
Yukiko Hidaka, Kyoko Fujimoto, Norikazu Matsuo, Takuma Koga, Shinjiro Kaieda, Satoshi Yamasaki, Munetoshi Nakashima, Kiyoshi Migita, Manabu Nakayama, Osamu Ohara, Tomoaki Hoshino, Ryuta Nishikomori, Hiroaki Ida
In total, 179 patients with unexplained fever treated between March 2011 and March 2017 at 56 Japanese hospitals, including Kurume University Hospital in Japan were enrolled in this study after taking the informed consent. We excluded 18 patients who were clinically diagnosed with other conditions, such collagen disease, infection, malignant tumor, immunodeficiency, myelodysplastic syndrome (MDS), and trisomy 8 (Figure 1). The 11 cases of collagen diseases included 4 cases of adult-onset Still’s disease, 1 case of aortitis, 1 case of vasculitis, 1 case of spondyloarthropathy, 1 case of mixed connective tissue disease, 1 case of central nervous system lupus, 1 case of dermatomyositis, and 1 case of incomplete type of Behçet disease. FMF was diagnosed if the patient met 1 or more major criteria, or 2 or more minor criteria of the modified Tel-Hashomer criteria [10]. The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Kurume University (No. 337).