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Head and Neck Pathology
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Ram Moorthy, Adrian T. Warfield, Max Robinson
Squamous cell papilloma (and recurrent respiratory papillomatosis) is the most common benign epithelial neoplasm affecting the larynx. It has a bimodal distribution with a peak before the age of 5 and a second between 20 and 40 years of age. There is convincing evidence that recurrent respiratory papillomatosis is due to human papillomavirus (HPV) infection, with HPV6 and 11 as the dominant subtypes.13 Macroscopically, the lesions are exophytic or sessile with a fine lobular surface that can be prone to bleeding when subjected to even minor trauma. Microscopically, the lesions have a typical papilloma appearance with hyperplastic squamous epithelium covering fibrovascular cores. Branching papillae covered by thin squamous epithelium may be seen, associated with a basal and parabasal cell proliferation. Koilocytes are often focally present in the upper and superficial zones and contain perinuclear halos. IHC and other studies can be used to confirm evidence of HPV infection, but are not required for diagnosis, treatment or to predict clinical behaviour.
The Objectives and Goals of Dermal Carcinogenicity Testing of Petroleum Liquids
Published in Rhoda G. M. Wang, James B. Knaak, Howard I. Maibach, Health Risk Assessment, 2017
James J. Freeman, Richard H. McKee
Histopathological evaluations are conducted on untreated and all treated skin specimens. Tumor numbers are confirmed and tumor types are identified. In the infrequent occasions in which a presumed squamous cell papilloma is identified during the course of the study but which subsequently regresses or is otherwise lost for histopathological evaluation, it is included in the final tumor tally. Any other relevant changes to the skin, e.g., irritation, are also characterized histopathologically.
In Situ Hybridization
Published in Attila Lorincz, Nucleic Acid Testing for Human Disease, 2016
Viral infections have been widely investigated. The abilities to detect human immunodeficiency virus (HIV), cytomegalovirus (CMV), human papillomavirus (HPV), herpes simplex virus (HSV), hepatitis B virus (HBV), Epstein–Barr virus (EBV), parvovirus B19, and polyoma viruses BK/JC are only some of the diagnostic applications of ISH methods96–104 (see Figure 5.1, panels A through E). More than 50 types of HPV exist and probes specific for the various types are available to assess infection by particular types associated with neoplastic development.103 HPV types 16 and 18 are more likely to be associated with malignant progression.104 The test has provided some insight into the epidemiology in that similar patterns of infections were identified in two cohorts separated by 25 years.103–105 However, the role played by HPV in other lesions including Bowen’s disease, squamous cell papilloma of bronchus, and larynx, is unclear.106–109
A bounding quantitative cancer risk assessment for occupational exposures to asphalt emissions during road paving operations
Published in Critical Reviews in Toxicology, 2018
Lorenz R. Rhomberg, David B. Mayfield, Robyn L. Prueitt, James W. Rice
Clark et al. (2011) evaluated the carcinogenic potential of paving fume condensates generated from a technique representative of exposures experienced during paving applications (i.e. field-matched fume as reported by Kriech et al. 2007). The paving fume condensate contained a total 4- to 6-ring PAC concentration of 34 mg/kg and a fluorescence measurement of 30 EU/g. This condensate was applied to the clipped backs (10% of total surface area) of C3H/HeNCrl male mice daily for 104 weeks. The test doses included both a vehicle (mineral oil) control group (80 animals), a positive (0.05% benzo[a]pyrene) control group (50 animals), and the paving fume condensate (50 mg weekly dose; 80 animals). Clark et al. (2011) reported no significant differences between the paving and vehicle control groups for survival, body weights, food consumption, clinical chemistry, dermal irritation, or tumorigenic effects. At the end of the experiment, one incidental benign squamous cell papilloma was observed in a paving asphalt treated animal at 102 weeks.
Previously Unreported Esophageal Lymphoid Polyp in a Child: A Case Report with Histopathology
Published in Fetal and Pediatric Pathology, 2023
Fatemeh Elham Mahjoub, Fariba Seighaly, Maryam Mirahmad, Pooria Asili
Benign esophageal tumors are uncommon. Most of the benign tumors are frequently detected by chance and are often slow growing. After diagnosis, they only need periodic monitoring [1]. These benign esophageal tumors are more often located in the lower and middle third of the esophagus. Tumors that are located in the upper third of the esophagus are uncommon, with the exception of fibrovascular polyps. Esophageal tumors are divided into intraluminal, intramural, and submucosal groups. Squamous cell papilloma, inflammatory pseudopolyp, fibrovascular polyp, lipoma, fibroneuroid tumor, and fibrolipoma are examples of intraluminal tumors. Intramural and submucosal tumors frequently are asymptomatic and are incidentally detected during the investigation of other pathologies [2].
Patency of the lacrimal drainage system in patients with a peripunctal tumour
Published in Orbit, 2020
Eri Ishikawa, Maria Suzanne Sabundayo, Shinjiro Kono, Hirohiko Kakizaki, Yasuhiro Takahashi
The histopathological results were consistent with intradermal nevus in 3 patients, compound nevus in 2 patients, blue nevus in 1 patient, epidermal cyst in 1 patient, squamous cell papilloma in 1 patient, and granulation tissue in 2 patients (Figure 1e–h). All surgeries were performed under local anaesthesia in an operating room. The tumours were simply excised except in the patient with an epidermal cyst who underwent tumour removal via a skin incision. A bicanalicular lacrimal tube was inserted and was removed after 3 months in all patients. All lacrimal puncta were patent, and none of the patients complained of epiphora after surgery.