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Pathology of Breast Cancer
Published in Raymond Taillefer, Iraj Khalkhali, Alan D. Waxman, Hans J. Biersack, Radionuclide Imaging of the Breast, 2021
The distinction between fibroadenoma and benign phyllodes tumor poses another diagnostic challenge in nonsurgical sampling of breast lesions. Malignant phyllodes tumors often present with mitoses and nuclear atypia. Benign phyllodes tumor has an unpredictable clinical outcome and often occurs at an older age than fibroadenomas. It is advisable to recommend surgical excision if a breast lesion shows increased stromal cellularity in both FNAB and core biopsy [25].
Breast disorders in children and adolescents
Published in Joseph S. Sanfilippo, Eduardo Lara-Torre, Veronica Gomez-Lobo, Sanfilippo's Textbook of Pediatric and Adolescent GynecologySecond Edition, 2019
Nirupama K. De Silva, Monica Henning
Primary sarcoma of the breast is rare in all age groups and exceedingly rare in children. Rhabdomyosarcoma can occur as a primary tumor of the breast, usually in adolescent girls. They are usually rapidly growing, mobile masses with no skin involvement. Histologically, these are usually alveolar.79 Liposarcoma has been reported within a phyllodes tumor of the breast in an adolescent patient.80 These tumors may appear encapsulated but should be treated by wide local excision.59 Fibrosarcoma and malignant fibrous histiocytoma may be the most common soft tissue sarcoma of the breast.59 Other, rare primary sarcomas of the breast include fibrosarcoma, fibrous histiocytoma, leiomyosarcoma, and osteogenic sarcoma.59 Primary non-Hodgkin lymphoma of the breast has also been reported in children.81
Breast and Endocrine Surgery
Published in Kaji Sritharan, Samia Ijaz, Neil Russell, Tim Allen-Mersh, 300 Essentials SBAs in Surgery, 2017
Kaji Sritharan, Samia Ijaz, Neil Russell, Tim Allen-Mersh
A 66-year-old woman presents with a well-circumscribed, painless lump in the upper outer quadrant of her left breast. Her last mammogram was performed a year ago and was entirely normal. Which of the following statements is true? Repeat mammography is not required, since the last one was performed only a year ago.Ultrasound is not useful, given her age.Fixity of the lump to underlying structures suggests it is likely to be malignant.Phyllodes tumour is the most likely diagnosis.Blood tests for tumour markers should be sent.
Chemotherapy and targeted treatments of breast sarcoma by histologic subtype
Published in Expert Review of Anticancer Therapy, 2021
Stefania Kokkali, Athina Stravodimou, Jose Duran-Moreno, Nektarios Koufopoulos, Ioannis a Voutsadakis, Antonia Digklia
Phyllodes tumors of the breast (PTB) are fibroepithelial tumors projecting into stromal elements. They represent comparatively rare neoplasms, comprising less than 1% of all breast tumors. The average annual incidence rate is about 2.1 per million women in the United States with a slight predominance in Latina whites. The World Health Organization (WHO) classifies PTB into three subtypes: benign, borderline and malignant based on the features of tumor border, stromal cellularity, atypia, overgrowth, mitotic activity, and the presence of malignant heterogenous element and with an overall average distribution of 60%, 20%, and 20%, respectively [110]. Typically, phyllodes tumors occur in women with a mean age at presentation of 40 years, without any identifiable etiologic factors, even if some cases associated with Li-Fraumeni syndrome have been reported [31].
Phyllodes Tumor of the Bladder in a 2-Year-Old Boy – An Exceptional Finding
Published in Fetal and Pediatric Pathology, 2023
Taycir Cheikhrouhou, Mahdi Ben Dhaou, Slim Charfi, Manar Hbaieb, Mohamed Zouari, Hayet Zitouni, Tahya Sellami Boudawara, Riadh Mhiri
Phyllodes tumors are uncommon fibroepithelial lesions that account for less than 1% of all breast neoplasms [1]. They have a foliated structure composed of cellular stroma and benign epithelial elements. Although the breast is the most well-known and common location for this tumor, a few cases have been reported in extramammary locations such as the prostate and seminal vesicle [1–5]. Oliveira et al. discovered ectopic breast tissue in a rat’s urinary bladder in 2007 [6], and in 2017, Tchrakian et al. reported the first human bladder phyllodes tumor in a 54-year-old man [7]. Previous reports of pediatric phyllodes tumors of the bladder in English literature are lacking.