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Cancer
Published in Sally Robinson, Priorities for Health Promotion and Public Health, 2021
Mesothelioma is a carcinoma which usually starts in the double outer linings of the lungs, the pleura. Typically, it spreads to lung tissue and the diaphragm. Peritoneal mesothelioma is found in the surface linings of other organs in the abdomen. It is quite a rare cancer which is strongly linked to asbestos, an insulation material banned in 1999 in the UK. Table 14.9 compares the psychological impact of mesothelioma with lung cancer.
Exposure to Air Pollution: How Particles Enter the Body
Published in Antonietta Morena Gatti, Stefano Montanari, Advances in Nanopathology From Vaccines to Food, 2021
Antonietta Morena Gatti, Stefano Montanari
Of course, the particles which don't enter the bloodstream and remain in the lungs can induce a pathology as well. The variety of lung tissue reactions ranges from granulomatosis to fibrosis to cancer. The type of reaction depends essentially on the characteristics of the particulate matter, namely morphology, size, chemical composition and degradation/corrosion. Peritoneal mesothelioma is a typical cancer of the serous membrane which wraps the lungs. The peculiarity of the lung mesothelioma induced by asbestos particulate matter depends on the morphology of the asbestos (a mineral fibre with one dimension at the nanoscale) and on its partial degradability once inside the extracellular fluids.
Lung cancer and mesothelioma
Published in Peter Hoskin, Peter Ostler, Clinical Oncology, 2020
Mesothelioma is not caused by smoking. It is now recognized that asbestos exposure is the main risk factor for both pleural and peritoneal mesothelioma. Blue asbestos (crocidolite) is more carcinogenic than white and brown types, and this is due to the size and shape of the asbestos fibres. Not only asbestos workers, but their spouses are also at risk as the fibres are carried home on their clothing. There is a long latent period (often 30–40 years) between asbestos exposure and development of mesothelioma, and cancer risk depends on duration and intensity of fibre exposure. Most patients have no evidence of asbestosis. About half will give a history of occupational exposure to asbestos. Patients with a possible occupational history of asbestos exposure should be identified as they may be eligible for industrial injuries compensation. Such patients should have a post-mortem examination.
Pretreatment Controlling Nutritional Status Score and Lactate Dehydrogenase as Predictive Markers of Survival in Patients with Malignant Peritoneal Mesothelioma
Published in Nutrition and Cancer, 2018
Qing-Qing Wang, Guo-Qi Zheng, Dong-Liang Yang, Yu-Fei Liang, Wen-Jie Yin, Shan-Shan Su
This study had some limitations. First, it was a retrospective study at a single institution. Furthermore, peritoneal mesothelioma is very rare and the number of cases studied was small, which could affect the results. Moreover, any nutritional evaluation tool needs to demonstrate high sensitivity and specificity. The limited number of sarcoma-type tumors in the study limited its power to detect the possible prognostic importance of the studied factors for tumor type. We were also unable to compare other widely used nutritional indices, such as the Subjective Global Assessment and Mini Nutritional Assessment, because detailed nutritional information, including dietary intake, weight change, and physical examination findings of muscle and fat were not obtained.
Projection of future numbers of mesothelioma cases in the US and the increasing prevalence of background cases: an update based on SEER data for 1975 through 2018
Published in Critical Reviews in Toxicology, 2022
In Figure 3b for peritoneal mesothelioma, the time-pattern of the rates is flat for both males and females with annual random fluctuations for both. The incidence rate for peritoneal mesothelioma is smaller than the rate for pleural mesothelioma and does not increase with increasing exposure to asbestos for either men or women.
Intraperitoneal chemotherapy for peritoneal metastases: an expert opinion
Published in Expert Opinion on Drug Delivery, 2020
Wim Ceelen, Helena Braet, Gabrielle van Ramshorst, Wouter Willaert, Katrien Remaut
Promising results have been obtained using CRS and HIPEC in patients with malignant peritoneal mesothelioma, a condition for which very few other effective therapy options are available. A systematic review of six published series totaling 240 patients showed a median survival ranging from 34 to 92 months [108].