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The breasts
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Nipple adenoma is a rare lesion that most commonly presents as a reddened rounded nodule, sometimes with skin ulceration or mimicking Paget's disease of the nipple. It is composed of proliferating ductal epithelium often with a papillary structure; some of these lesions may indeed be a form of retroareolar benign papilloma.
Tumors of Cutaneous Appendages
Published in Omar P. Sangueza, Sara Moradi Tuchayi, Parisa Mansoori, Saleha A. Aldawsari, Amir Al-Dabagh, Amany A. Fathaddin, Steven R. Feldman, Dermatopathology Primer of Cutaneous Tumors, 2015
Nipple adenoma: Endophytic lesion, often open toward the epidermal surfaceWedge-shaped and consists of tubular elements covered by a double row of epithelial cellsTubules are separated from one another by fibrous septa
Breast Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
Tumors of the breast include (1) epithelial tumors (invasive ductal carcinoma [IDC] not otherwise specified [NOS] [mixed-type carcinoma, pleomorphic carcinoma, carcinoma with osteoclastic giant cells, carcinoma with choriocarcinomatous features, carcinoma with melanotic features], invasive lobular carcinoma [ILC], tubular carcinoma, invasive cribriform carcinoma, medullary carcinoma, mucinous carcinoma and other tumors with abundant mucin [mucinous carcinoma, cystadenocarcinoma and columnar cell mucinous carcinoma, signet ring cell carcinoma], neuroendocrine tumors [solid neuroendocrine carcinoma, atypical carcinoid tumor, small cell or oat cell carcinoma, large cell neuroendocrine carcinoma], invasive papillary carcinoma, invasive micropapillary carcinoma, apocrine carcinoma, metaplastic carcinomas [pure epithelial metaplastic carcinomas—squamous cell carcinoma, adenocarcinoma with spindle cell metaplasia, adenosquamous carcinoma, mucoepidermoid carcinoma; mixed epithelial or mesenchymal metaplastic carcinomas], lipid-rich carcinoma, secretory carcinoma, oncocytic carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, glycogen-rich clear cell carcinoma, sebaceous carcinoma, inflammatory carcinoma, lobular neoplasia [lobular carcinoma in situ, or LCIS], intraductal proliferative lesions [usual ductal hyperplasia, flat epithelial atypia, atypical ductal hyperplasia, ductal carcinoma in situ], microinvasive carcinoma, intraductal papillary neoplasms [central papilloma, peripheral papilloma, atypical papilloma, intraductal papillary carcinoma, intracystic papillary carcinoma], benign epithelial proliferations [adenosis including variants—sclerosing adenosis, apocrine adenosis, blunt duct adenosis, microglandular adenosis, adenomyoepithelial adenosis; radial scar or complex sclerosing lesion; adenomas—tubular adenoma, lactating adenoma, apocrine adenoma, pleomorphic adenoma, ductal adenoma]), (2) myoepithelial lesions (myoepitheliosis, adenomyoepithelial adenosis, adenomyoepithelioma, malignant myoepithelioma), (3) mesenchymal tumors (hemangioma, angiomatosis, hemangiopericytoma, pseudoangiomatous stromal hyperplasia, myofibroblastoma, fibromatosis—aggressive, inflammatory myofibroblastic tumor, lipoma [angiolipoma], granular cell tumor, neurofibroma, schwannoma, angiosarcoma, liposarcoma, rhabdomyosarcoma, osteosarcoma, leiomyoma, leiomyosarcoma), (4) fibroepithelial tumors (fibroadenoma, phyllodes tumor [benign, borderline, malignant], periductal stromal sarcoma—low grade, mammary hamartoma), (5) tumors of the nipple (nipple adenoma, syringomatous adenoma, Paget disease of the nipple), (6) malignant lymphoma (diffuse large B-cell lymphoma, Burkitt lymphoma, extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT] type, follicular lymphoma), (7) metastatic tumors, and (8) tumors of the male breast (gynecomastia, carcinoma [invasive, in situ]) [1,2].
A tale of three common nipple diseases
Published in Baylor University Medical Center Proceedings, 2022
Mahmud Alkul, Christine P. Lin, Jay Truitt, Michelle B. Tarbox
Paget’s disease of the nipple is a rare type of breast carcinoma of the nipple-areola complex, is often associated with an underlying in situ or invasive carcinoma, and occurs most commonly in postmenopausal women.1 It typically presents as a thickened, erythematous, weeping or crusted lesion with irregular borders that can be pruritic or tender. Advanced lesions may extend into the surrounding skin and present with erosion, ulceration, scaling, and bleeding.1,2 On histology, there are large cells with clear cytoplasm and hyperchromatic nuclei invading the epidermis, so-called Paget’s cells, with cytokeratin 7 staining positive in nearly all cases.1 Nipple adenoma and nipple dermatitis may mimic Paget’s disease clinically, leading to a delayed or missed diagnosis.1,2 In this report, we present a case of Paget’s disease of the nipple in a 73-year-old woman with a brief review of other common nipple diseases.