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Gastrointestinal and hepatobiliary
Published in Dave Maudgil, Anthony Watkinson, The Essential Guide to the New FRCR Part 2A and Radiology Boards, 2017
Dave Maudgil, Anthony Watkinson
The following lesions may occur in the appendix. True or false? Kaposi’s sarcoma.Adenoma.Lymphoma.Signet cell tumour.Malignant fibrous histiocytoma.
Tumors of Fibrous Tissue
Published in Omar P. Sangueza, Sara Moradi Tuchayi, Parisa Mansoori, Saleha A. Aldawsari, Amir Al-Dabagh, Amany A. Fathaddin, Steven R. Feldman, Dermatopathology Primer of Cutaneous Tumors, 2015
Malignant fibrous histiocytoma: Partial fibroblastic and histiocytic differentiationCollagen productionMultinucleated cells usually present
Ancient neurilemmoma of the facial nerve in the parotid gland
Published in Acta Oto-Laryngologica Case Reports, 2020
Abhilasha Goswami, Mukul Patar
Ancient Neurilemmoma: The term ‘ancient schwannoma’ was coined by Ackerman and Taylor in 1951 to describe a tumour that had undergone degenerative changes [3]. These degenerative features such as degenerative atypia, interstitial hyalinization and cells with large, hyperchromatic nuclei, are attributed to the growth and degeneration/aging of the tumour. As the schwannoma grows to a size beyond the capacity of its blood supply, central tumour necrosis occurs, leading to degeneration. In spite of this ‘aging’, ancient schwannomas behave similar to schwannomas, i.e. they are benign, slow-growing, neurogenic tumours with negligible potential of malignant transformation. This is a relatively rare condition, and is most often diagnosed in elderly patients. They are often misdiagnosed as malignant fibrous histiocytoma or malignant nerve sheath tumours due to the cystic degeneration seen on radiological investigations.
Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: Rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy
Published in OncoImmunology, 2018
Emily Z. Keung, Jen-Wei Tsai, Ali M. Ali, Janice N. Cormier, Andrew J. Bishop, B. Ashleigh Guadagnolo, Keila E. Torres, Neeta Somaiah, Kelly K. Hunt, Jennifer A. Wargo, Alexander J. Lazar, Wei-Lien Wang, Christina L. Roland
H&E slides of pre-treatment and post-treatment specimens were reviewed by pathologists who specialize in bone and soft tissue tumors (WLW, AJL, JWT). Diagnosis of undifferentiated pleomorphic sarcoma (formerly known as malignant fibrous histiocytoma) was confirmed using criteria established as a diagnosis of exclusion per the criteria of the 2013 WHO Classification of Tumours of Soft Tissue and Bone. In post treatment specimens, the percentage present of certain features related to treatment effect was assessed. Histological features of treatment effect include decreased cellularity, hyalinization (dense collagen deposition), tumor necrosis (though this is impossible to distinguish from tumor necrosis associated with higher grade tumors in many post treatment cases), and cytological changes (enlarged cytoplasm with enlarged bizarre nuclei with smudgy chromatin and sometimes pseudo-nuclear vacuoles). Many cases had variable hyalinization and necrosis. The percentage of how much treatment effect was hyalinization or necrosis was estimated.
An ultrastructural pathologist’s views on fibroblasts, modified smooth muscle cells, wound healing, stenosing arteriopathies, Kawasaki disease, Dupuytren’s contracture, and the stroma of carcinomas
Published in Ultrastructural Pathology, 2020
For decades, the MF has been a frustrating subject for ultrastructuralists, e.g., the malignant fibrous histiocytoma (MFH) has been the most often diagnosed soft tissue sarcoma, as well as a common default diagnosis.74 It is clear that two of its cells don’t even exist, i.e., fibro-histiocytes and myofibroblasts. MFH is actually a unique type of malignant inflammatory fibrosarcoma. Clinico-pathologic studies using TEM, IHC, and genetic analysis have been critical to the correction.74