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Adverse Effects and Intoxication with Essential Oils
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
However, hepatotoxicity might have played a role in the development of the hepatic tumors in B6C3F1 mice, which are known to be sensitive to the development of liver tumors by non-genotoxic mechanisms. Thus, it is assumed that these data are not relevant to human risk, as the increase in the incidence of tumors in male B6C3F1 mice reflects the impact of high-dose liver damage to an organ already prone to spontaneous development of liver neoplasms (Haseman et al., 1986) (Table 19.2).
Assessment of Hepatocarcinogenesis by Early Indicators
Published in Robert G. Meeks, Steadman D. Harrison, Richard J. Bull, Hepatotoxicology, 2020
Norio Hirota, Gary M. Williams
In 1963, Abelev made the discovery of the appearance of a fetal protein, a-fetoprotein (AFP), in the serum of adult mice with liver cancer (Abelev, 1971). Subsequently, production of this protein by both human and rat hepatocellular carcinomas was documented. Moreover, several laboratories (Watabe, 1971; Kitagawa et al., 1972; Kroes et al., 1972; Sell, 1978) independently found that an increase in serum AFP could be detected within a few weeks of carcinogen administration, long before the development of liver cancers. These studies demonstrated a biphasic pattern of the elevation of AFP; after early induction, if carcinogen exposure was discontinued, AFP diminished and reappeared only with the development of liver neoplasms. Thus, elevation of serum AFP was established as an indicator both of the early effects of liver carcinogens and of the presence of liver neoplasms.
Liver and biliary system, pancreas and spleen
Published in A Stewart Whitley, Jan Dodgeon, Angela Meadows, Jane Cullingworth, Ken Holmes, Marcus Jackson, Graham Hoadley, Randeep Kumar Kulshrestha, Clark’s Procedures in Diagnostic Imaging: A System-Based Approach, 2020
A Stewart Whitley, Jan Dodgeon, Angela Meadows, Jane Cullingworth, Ken Holmes, Marcus Jackson, Graham Hoadley, Randeep Kumar Kulshrestha
The strength of MRI is the characterisation of liver lesions and differentiation of benign and malignant abnormalities [13]. In the case of suspected malignancy, imaging of the liver is undertaken for the detection and characterisation of suspected primary or secondary neoplasms for planning surgery or chemotherapy, assessing treatment response, evaluating biliary pathology and screening for liver neoplasms in high-risk groups.
Sarcopenia Predicts Prognosis of Patients Undergoing Liver Resection for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Published in Nutrition and Cancer, 2023
Hao Zhang, Li Zhang, Yi Wang, Ji Zou, Ting Zhang
This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (26). Literature search were performed independently by two investigators (L.Z. and T.Z.) and included all articles published in PubMed, SinoMed, Embase, Cochrane Library, Medline, and Web of Science up to August 2022. The following keywords were used: “HCC” or “liver cancer” or “liver neoplasms” combined with the key words “sarcopenia” or “skeletal muscle index” or “muscle mass” and “hepatectomy” or “liver resection” or “liver surgery.” We also examined the list of references contained in the study to identify undetected relevant studies. No restrictions such as publication date or journal category filtering are employed in the search strategies. The literature search was restricted to English articles published before August 1, 2022.
Percutaneous thermal ablation versus open liver resection for recurrent hepatoblastoma: a retrospective study
Published in International Journal of Hyperthermia, 2021
Si-tong Chen, Zhi-yu Han, Ping Ling, Xiao-ling Yu, Zhi-gang Cheng, Fang-yi Liu, Hong Jiang, Jie Yu
Percutaneous TA is the first-line treatment for early liver cancer in adults, especially when the tumor is less than 3 cm in size, and can achieve an effect similar to that of surgery [22–24]. Percutaneous TA has also been gradually applied in the treatment of pediatric liver neoplasms. Hetzer et al. [11] safely deployed stereotactic RFA (11 sessions, 15 lesions) in 10 pediatric patients with liver masses and extrahepatic metastasis, and follow-up imaging studies (median: 55 months, range: 18–129 months) revealed no local or distant recurrence of disease in any patient. Steven et al. [13] used RFA to treat five patients with 23 HB metastases in the lungs, liver, or bone and achieved local control in 22 of them (95.6%) at a median follow-up period of 30.1 months (range: 18.9–65.7 months) after RFA. Although some [10,13,14,16] studies have initially offered details on the safety and effectiveness of TA in the treatment of pediatric HB, these investigations were published in a case report format, and it is still unknown whether TA can achieve a similar effect as that of OLR in HB.
Prognostic Value of Prealbumin in Liver Cancer: A Systematic Review and Meta-Analysis
Published in Nutrition and Cancer, 2020
Weizhou Qiao, Feng Leng, Tong Liu, Xuan Wang, Yueying Wang, Dongjie Chen, Jinlong Wei
A systematic literature search was performed in PubMed, Web of Science, EMBASE, and the Cochrane library for eligible studies that explored the relationship between prealbumin and the prognosis of liver cancer. The main search terms included: (“liver neoplasms”, “hepatocellular cancer”, “hepatic cancer,” and “liver cancer”) and (prealbumin, transthyretin, proalbumin, and pre-albumin). The complete search used for PubMed was: [[[[[“Liver Neoplasms” (Mesh)] OR hepatocellular cancer] OR hepatic cancer] OR liver cancer]] AND [[[[“Prealbumin” (Mesh)] OR transthyretin] OR proalbumin] OR pre-albumin]; the complete search used for Embase was: (“liver cancer”/exp OR “liver neoplasms” OR “hepatocellular cancer” OR “hepatic cancer”) AND (“transthyretin”/exp OR prealbumin OR proalbumin OR “pre-albumin”). Entirely candidate studies were fulfilled by two independent authors (Feng Leng and Tong Liu) and disagreements were resolved by the first author (Weizhou Qiao). The retrieval time was up to date April 15, 2019.