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DRCPG MCQs for Circuit A Answers
Published in Una F. Coales, DRCOG: Practice MCQs and OSCEs: How to Pass First Time three Complete MCQ Practice Exams (180 MCQs) Three Complete OSCE Practice Papers (60 Questions) Detailed Answers and Tips, 2020
Clear cell and endometrioid tumours are almost all malignant. Dysgerminoma and immature teratoma are the most common malignant ovarian germ-cell tumours. Thirty per cent of serous, 15% of mucinous and <5% of Brenner tumours are malignant. Three to 5% of Sertoli-Leydig cell tumours (arrhenoblastomas) are malignant. The Krukenberg tumour is a metastatic tumour from the stomach that contains signet-ring cells in the ovarian stroma.
Knowledge Area 14: Gynaecological Oncology
Published in Rekha Wuntakal, Ziena Abdullah, Tony Hollingworth, Get Through MRCOG Part 1, 2020
Rekha Wuntakal, Ziena Abdullah, Tony Hollingworth
This is called Krukenburg tumour. It occurs due to metastasis from the gastrointestinal tract tumours to the ovary. The most common primary is from stomach. The typical cells seen on histology of these metastatic GI tumours to ovaries are “signet ring” cells. These tumours on the ovary are usually bilateral and symmetrical on both sides.Further readingSarris I, Sangeeta A, Susan B. Training in Obstetrics and Gynecology: The Essential Curriculum. Oxford, UK: Oxford University Press, 2009, pp. 391–416.
Hereditary Diffuse Gastric Cancer
Published in Dongyou Liu, Handbook of Tumor Syndromes, 2020
If cancer metastasizes to other sites, symptoms may include hepatomegaly (enlarged liver), yellowing of the eyes and skin (jaundice), Virchow node (left supraclavicular adenopathy), Sister Mary Joseph node (periumbilical nodule), Irish node (left axillary node), Krukenberg tumor (ovary mass), Blumer shelf (cul-de-sac mass), ascites (peritoneal carcinomatosis, an abnormal buildup of fluid in the peritoneum), skin nodules (firm lumps under the skin), and fractures (broken bones).
CD44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor
Published in Expert Review of Molecular Diagnostics, 2023
Ziqi Zhou, Can Li, Zhiyu Wang, Johannes Haybaeck, Cuiwei Zhang
In 1896, Friedrich Ernst Krukenberg, a German gynecologist and pathologist, reported the first five cases of Krukenberg tumor (KT), which was initially named as a ‘fibrosarcoma ovarii mucocellulare (carcinomatodes)’ [12–14]. KT, accounting for 1–2% of all ovarian tumors, is a special type of ovarian carcinoma in which malignant tumors are derived primarily from the seeding of malignant gastrointestinal tissues, specifically mucinous gastric carcinoma (MGC) [13,15]. The situation is slightly different in Asian countries, such as Japan, Korea, and China, where the incidence of KT is higher and accounts for 20% of all ovarian cancers [16]. Histopathological studies have reported that the most common primary tumor origin that might lead to the development of KTs is GC (up to 78.9% of cases), followed by colorectal cancer (up to 72.19% of cases) [17,18]. Metastasis is the leading cause of cancer-related death, involving the emigration of tumor cells from the primary tumor, circulation, settlement in distant organs, and growth in a foreign environment [19].
Incidentally found mucinous epithelial tumors of the appendix with or without pseudomyxoma peritonei: diagnostic and therapeutic algorithms based on current evidence
Published in Acta Chirurgica Belgica, 2021
Wim Ceelen, Marc De Man, Wouter Willaert, Gabrielle H. van Ramshorst, Karen Geboes, Anne Hoorens
In patients with pseudomyxoma peritonei, the peritoneal metastatic disease is graded separately from the primary tumor, which is different from any other tumor type in the luminal GI tract (Table 3). Although the grade of the primary neoplasm and its peritoneal metastases are often concordant, it is important to realize that this is not always the case. The authors have observed several patients with high-grade peritoneal lesions despite having low-grade appendiceal neoplasms. In female patients, ovarian metastases are often observed, and these tend to grow rapidly and therefore may lead to an incorrect initial diagnosis of ovarian cancer. The traditional Krukenberg tumor denotes ovarian metastases in which signet ring cells are predominant [13].
Metastatic oesophageal cancer to the ovary: an unusual case
Published in Journal of Obstetrics and Gynaecology, 2018
Efterpi Tingi, Khawla Aswad, Manal Atwan
Krukenberg tumours (KT) are uncommon tumours indicating any ovarian metastatic carcinoma deriving from a primary malignancy (Jiang et al. 2009). They represent only 1–2% of all ovarian tumours, with an estimated incidence of 0.16 per 100,000 per year (Hiremath et al. 2015). The vast majority of KT originate from gastric adenocarcinoma, followed by colon, biliary system, jejunum and pancreas (Lash and Hart 1987). Oesophageal metastases to the female genital tract are extremely rare, but they significantly worsen the prognosis. We present a rare case of a Krukenberg tumour arising from an oesophageal adenocarcinoma.