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Olfactory Esthesioneuroblastoma
Published in Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
In 1981, Homzie and Elkon4 found 173 cases reported in the literature. These included 97 cases reported from 1924 to 1966 and reviewed by Skolnick et al.5 and 76 cases reported in the 15 years after 1966. This increased rate of documented cases in the past few years may reflect either an increase in tumor incidence or merely a greater awareness of the tumor. Esthesioneuroblastoma comprises 1.5 to 3% of nasal tumors in man.6
Central Nervous System, Head and Neck
Published in Vincent Helyar, Aidan Shaw, The Final FRCR, 2017
In total, 80%–90% are SCCs. It is often clinically silent or may present with an obstructive sinusitis and bone destruction. Esthesioneuroblastoma is a destructive tumour arising from the olfactory nerve/neurosensory cells of the nasal mucosa and often invades the anterior cranial fossa.
Nasal Cavity and Paranasal Sinus Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
Clinical presentation of esthesioneuroblastoma (or olfactory neuroblastoma) is usually secondary to nasal stuffiness and rhinorrhoea or epistaxis. Large tumor extending into the intracranial compartment (25%–30% at diagnosis) may cause anosmia. Lethal midline granuloma is associated with rhinorrhea, epistaxis, nasal stuffiness, obstruction, and pain.
Esthesioneuroblastoma as a cause of syndrome of inappropriate antidiuretic hormone
Published in Acta Oto-Laryngologica Case Reports, 2022
Wynne Q. Zhang, Mica D. Glaun, Ali Jalali, Susan L. Samson, K. Kelly Gallagher
Esthesioneuroblastoma (ENB) or olfactory neuroblastoma is a rare malignant tumor of the neuroectoderm-derived olfactory epithelium that normally lines the superior nasal cavity and is responsible for reception of odorant stimuli. ENB frequently presents with nonspecific symptoms of obstruction, facial pain/pressure, epistaxis, or hyposmia/anosmia, but less commonly has been associated with paraneoplastic syndromes, including syndrome of inappropriate antidiuretic hormone (SIADH) or ectopic adrenocorticotropic hormone (ACTH) production [1]. We describe a case of ENB diagnosis preceded by a complicated presentation of SIADH with resolution of hyponatremia following surgical removal.
Esthesioneuroblastoma presenting with orbital signs and ectopic adrenocorticotropic hormone syndrome
Published in Baylor University Medical Center Proceedings, 2022
Wesley M. Gillette, Donald Carroll Hubbard, Jana Nicole Waters, Adam Stephen Johnson
Esthesioneuroblastoma, also known as olfactory neuroblastoma, is a rare tumor that arises from the olfactory neuroepithelium.1 Patients commonly present with nasal congestion or epistaxis; however, extension of this tumor into the orbit can also result in ophthalmic signs and symptoms such as proptosis, diplopia, and epiphora.2 Some cases may also be associated with paraneoplastic syndromes such as syndrome of inappropriate antidiuretic hormone secretion or ectopic adrenocorticotropic hormone syndrome (EAS).3 Herein, we present a case of esthesioneuroblastoma manifesting initially with orbital signs and sequelae of EAS.
Secondary extradural spinal manifestation of esthesioneuroblastoma
Published in British Journal of Neurosurgery, 2019
Bujung Hong, Elvis J. Hermann, Friedrich Feuerhake, Joachim K. Krauss
Histopathological examination showed similar morphological features as seen in the cranial esthesioneuroblastoma removed earlier (Figure 2). The tumour cells were poorly differentiated with a vaguely retained lobular architecture. Immunohistochemistry detected focal reactivity for Neuronal Cell Adhesion Molecule (NCAM/CD56) that confirmed a neuroendocrine differentiation. CD 56 and cytokeratin (CK) 7 were positive. These findings were consistent with the diagnosis of a secondary manifestation of the previously resected esthesioneuroblastoma.