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Pancreatic malignancy
Published in Anju Sahdev, Sarah J. Vinnicombe, Husband & Reznek's Imaging in Oncology, 2020
Giovanni Morana, Alex Faccinetto, Michele Fusaro
Histologically, it is composed of multiple cysts formed by glycogen-rich, PAS-positive epithelial cells. It is a benign lesion, and very few cases of serous cystadenocarcinoma have been documented (85). In 15%–30% of the cases, SCA is associated with von Hippel–Lindau (VHL) disease (86).
The Pancreas and the Periampullary Area
Published in E. George Elias, CRC Handbook of Surgical Oncology, 2020
These two tumors, benign and malignant, are rare tumors to the pancreas. They may comprise 4 to 10% of all pancreatic cysts with more tendency to be in women than in men. The usual age group is between 45 and 60. These patients usually present with epigastric fullness and pain in the upper part of the abdomen without a history of abdominal trauma, or excessive alcohol consumption. The duration of symptoms can range from 2 months to 2 years, with an average duration of 18 months. These tumors can grow very slowly and never present clinically, and they are discovered at the time of autopsy. On the other hand, those who present clinically may present with associated other conditions including diabetes mellitis, abnormal thyroid function tests, polycystic disease of the liver and kidneys, or biliary disease. Roentgenologically, there are no classical diagnostic signs for these tumors. Occasionally, calcification is seen in the wall of the cyst in about 10% of the cases. Almost two thirds of these tumors are located in the body and the head of the pancreas and one third in the head. Cystadenomas can reach a large size and can be misdiagnosed as pseudocysts and are anastomosed to the back of the stomach or to the bowel. The surgeon should suspect cystadenoma if there is no previous history of pancreatitis, alcoholism, or abdominal trauma. On the other hand, cystadenocarcinomas are usually papillary type, and on opening the cyst, multiple papillae can be seen within the cavity of the cyst. A biopsy and frozen section can differentiate cystadenoma and cystadenocarcinoma from pseudocysts.
Liver, biliary system and pancreas
Published in Michael Gaunt, Tjun Tang, Stewart Walsh, General Surgery Outpatient Decisions, 2018
Satyajit Bhattacharya, Adrian O’Sullivan
The commonest tumour is primary hepatocellular carcinoma. Its incidence and geographical distribution parallels that of hepatitis B infection. It usually develops on a background of cirrhosis, but can also develop in a normal liver. Other rarer tumours include hepatocellular cholangiocarcinoma. This rare tumour shows features of both hepatocellular and cholangiocarcinoma and is thought to represent a coincidental occurrence of both. Cystadenocarcinoma tends to present as a large cystic tumour in adults. Sarcoma arises from the connective tissue elements of the liver and presents as a rapidly enlarging lesion associated with hypoglycaemia. Angiosarcoma is associated with the occupations linked to vinyl chloride production or ingestion of arsenic or anabolic steroids. It is an aggressive tumour.
Prostatic cystadenoma. A case-report illustrating diagnosis and surgical management of an unusual condition
Published in Scandinavian Journal of Urology, 2021
Vibeke M. Kristensen, Thomas Helgstrand, Janne Bayer Andersen, Kristi Krüger, Henrik Jakobsen
Prostatic cystadenoma is a rare condition with less than 30 cases reported [1,2]. Patients often present with obstructive LUTS and constipation due to the presence of a large tumor [1,2,4]. PSA elevation is the norm but not the rule [4]. When encountering a urological patient with obstructive LUTS, cystadenoma should not be the first working diagnosis. However, it should be borne in mind if DRE reveals soft compressible components, cystoscopy shows large and multiple impressions from surrounding tissue, and/or when retroperitoneal cystic tumors are visible from radiological examinations. Moreover, prostatic cystadenocarcinoma, the malignant counterpart, should be considered as a differential diagnosis. In the case of cystadenocarcinoma, it is essential that surgical resection is complete, as the risk of recurrence seems high [1,2,4]. An association between benign cystadenoma and malignant cystadenocarcinoma has been theorized, suggesting a continued spectrum from cystadenoma to cysteadenocarcinom. There is no clear evidence proving the spectrum theory; however, findings of cystadenocarcinoma components within the cystadenoma are a proven argument that appropriate management of the benign condition is essential for management of a potential malignant condition [2,5].
Mucinous cystadenocarcinoma in the renal pelvis: primary or secondary? Case report and literature review
Published in Acta Chirurgica Belgica, 2020
An Tamsin, Charlotte Schillebeeckx, Charlotte Van Langenhove, Kathy Vander Eeckt, Dieter Ost, Kevin Wetzels
Renal mucinous cystadenocarcinoma can be primary or secondary. As mucinous cystadenocarcinoma is an extremely uncommon entity in the kidney, the patient must be carefully evaluated for primary tumors of pancreas, ovary and appendix which are more common, as part of the clinical entity of pseudomyxoma peritonei [2]. Only one case of cystadenocarcinoma of the appendix presenting as a renal tumor has been published previously [11]. In our case, there were no pathology reports or slides of the appendectomy (35 to 40 years ago) available for review anymore. Appendiceal mucinous neoplasms may occasionally present as occult neoplasms, which may be difficult to identify grossly, and often, histologic evaluation of the entire appendix is necessary to exclude a mucinous adenoma or a microscopic focus of rupture [13]. That’s why in our case, a renal metastasis of a primary appendiceal mucinous neoplasm can’t be fully excluded. On the other hand, the time interval between appendectomy and renal tumor makes the causation unlikely.
Serum cytokines and CXCR2: potential tumour markers in ovarian neoplasms
Published in Biomarkers, 2020
Douglas Côbo Micheli, Millena Prata Jammal, Agrimaldo Martins-Filho, José Rodolfo Ximenes de Moraes Côrtes, Cristiane Naffah de Souza, Rosekeila Simões Nomelini, Eddie Fernando Candido Murta, Beatriz Martins Tavares-Murta
The anatomopathological analysis showed that most cases of non-neoplastic ovarian lesions were endometrioma (36.4%), followed by simple cysts (21.2%). Patients with benign neoplasia were mainly diagnosed with serous cystadenoma (31.9%), followed by mature cystic teratoma (27.8%) and mucinous cystadenoma (29.2%). In the malignant neoplasia group, papillary serous cystadenocarcinoma was the most frequent diagnosis (20.0%), followed by granulosa cell tumours (16.7%), borderline mucinous tumour (20.0%), borderline serous tumour (6.7%), dysgerminoma (6.7%), clear cell carcinoma (6.7%), and other diagnoses (3.3%). The other items included endometrioid adenocarcinoma, high-grade neoplasia, immature teratoma, Sertoli–Leydig cell tumour, germ cell tumour, endodermal sinus tumour, and giant cell adenocarcinoma, which were exhibited by one individual each.