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Nonfunctioning sellar masses
Published in Nadia Barghouthi, Jessica Perini, Endocrine Diseases in Pregnancy and the Postpartum Period, 2021
Craniopharyngiomas are typically benign. Due to the tumor’s location, however, pituitary gland compression and hormone dysfunction are common. In addition, these tumors can lead to compression of the optic chiasm which is located superiorly to the pituitary gland, resulting in visual defects.
Tumors of the Nervous System
Published in Philip B. Gorelick, Fernando D. Testai, Graeme J. Hankey, Joanna M. Wardlaw, Hankey's Clinical Neurology, 2020
Histologically, there are two subtypes of craniopharyngioma: Adamantinomatous type: more common in children; typically associated with calcification. Adamantinomatous craniopharyngiomas frequently harbor CTNNB1 mutations.Papillary type: more commonly seen in adults, and less likely to calcify. Papillary craniopharyngiomas tend to harbor BRAF V600E mutations.
Craniopharyngioma
Published in David A. Walker, Giorgio Perilongo, Roger E. Taylor, Ian F. Pollack, Brain and Spinal Tumors of Childhood, 2020
Hermann L. Müller, Claire Alapetite, Jeffrey Wisoff
Craniopharyngioma is a non-glial intracranial tumor derived from neoplastic transformation of embryonic tissue.5,53–56 Several observations, including cytokeratin expression profiles, indicate that craniopharyngiomas arise from neoplastic transformation of ectodermal-derived epithelial cell remnants of Rathke’s pouch and the craniopharyngeal duct. Epithelial cell rests have been reported to occur between the roof of the pharynx and the floor of the third ventricle, most frequently along the anterior infundibulum and the anterior superior surface of the adenohypophysis – sites of the previous Rathke pouch and involuted duct that links these structures. Metaplasia of cells derived from the tooth primordium leads to the adamantinomatous subtype, whereas metaplastic changes in cells derived from buccal mucosa primordium give rise to the squamous papillary variant.57 Further support for the origin of craniopharyngioma from Rathke’s pouch epithelium is the occasional occurrence of mixed tumors with characteristics of craniopharyngioma and Rathke cleft cysts.
A Latent Profile Analysis of Sleep, Anxiety, and Mood in Youth with Craniopharyngioma
Published in Behavioral Sleep Medicine, 2022
Sara M. Witcraft, Molly E. Wickenhauser, Kathryn M. Russell, Belinda N. Mandrell, Heather M. Conklin, Thomas E. Merchant, Valerie McLaughlin Crabtree
Craniopharyngioma is a rare brain tumor that arises in adults and children. Although histologically benign, its association with critical neurovascular structures and cerebrospinal fluid pathways results in significant morbidity at the time of presentation and later following surgery or radiation therapy (Cohen et al., 2011; Jacola et al., 2016). Long-term survival exceeds 90% in most series, regardless of treatment (Müller et al., 2001); however, the majority of patients (i.e., 52–87%) experience significant complications from tumor and treatment (Jacola et al., 2016). Psychosocial impairment (Klages et al., 2019; Müller, 2019), deficits in memory (Waber et al., 2006) and cognitive functioning (Fournier-Goodnight et al., 2017), vision loss (Merchant et al., 2002), and sleep dysregulation and excessive daytime sleepiness (EDS; Cohen et al., 2011; Jacola et al., 2016; Mandrell et al., 2020) are common in those diagnosed with craniopharyngioma and may compound disease- and treatment-related fatigue and/or negatively impact quality of life (Cohen et al., 2011).
Do Anxiety and Mood Vary among Disparate Sleep Profiles in Youth with Craniopharyngioma? A Latent Profile Analysis
Published in Behavioral Sleep Medicine, 2022
Sara M. Witcraft, Molly E. Wickenhauser, Kathryn M. Russell, Belinda N. Mandrell, Heather M. Conklin, Thomas E. Merchant, Valerie McLaughlin Crabtree
Craniopharyngioma is a rare brain tumor that arises in adults and children. Although histologically benign, its association with critical neurovascular structures and cerebrospinal fluid pathways results in significant morbidity at the time of presentation and later following surgery or radiation therapy (Cohen et al., 2011; Jacola et al., 2016). Long-term survival exceeds 90% in most series, regardless of treatment (Müller et al., 2001); however, the majority of patients (i.e., 52% – 87%) experience significant complications from tumor and treatment (Jacola et al., 2016). Psychosocial impairment (Klages et al., 2019; Müller, 2019), deficits in memory (Waber et al., 2006) and cognitive functioning (Fournier-Goodnight et al., 2017), vision loss (Merchant et al., 2002), and sleep dysregulation and excessive daytime sleepiness (EDS; Cohen et al., 2011; Jacola et al., 2016) are common in those diagnosed with craniopharyngioma and may compound disease- and treatment-related fatigue and/or negatively impact quality of life (Cohen et al., 2011).
Actigraphy versus Polysomnography to Measure Sleep in Youth Treated for Craniopharyngioma
Published in Behavioral Sleep Medicine, 2020
Kristin Niel, Kayla N. LaRosa, Kimberly L. Klages, Thomas E. Merchant, Merrill S. Wise, Sara M. Witcraft, Donna Hancock, Mary Caples, Belinda N. Mandrell, Valerie Mclaughlin Crabtree
Craniopharyngioma is a rare, benign epithelial brain tumor that occurs along an axis extending from the sella turica, through the pituitary stalk, and into the hypothalamus with 0.5–2.5 new cases per million each year (Poretti, Grotzer, Ribi, Schönle, & Boltshauser, 2004) representing 6 to 13% of all childhood brain tumors (Cohen, Guger, & Hamilton, 2011; Garrė & Cama, 2007). Often, as the tumor enlarges it invades nearby anatomical structures, and both the tumor and its resection and treatment can be associated with significant neurological and endocrinological complications (Cohen et al., 2011). Although the long-term survival of youth with craniopharyngioma is high, their quality of life (QoL) after neurosurgical intervention is often marked by excessive daytime sleepiness (EDS), decreased physical activity, hypothalamic obesity, mood changes, and weak performance on neurocognitive measures and academic fluency (Cohen et al., 2011; Fournier-Goodnight et al., 2017). In 52–87% of cases, the location of the tumor has been found to cause disruption of the hypothalamic-pituitary-adrenal (HPA) axis (Muller, 2008); notably, the HPA axis is an area of the brain that plays a central role in the regulation of sleep and wake (Muller, 2016). Given the functions of the brain that are associated with the location of the tumor, youth undergoing resection have substantially decreased sleep latency, and higher likelihood of EDS and narcolepsy (Jacola et al., 2016; Muller, 2010; Muller et al., 2006; Muller, Handwerker, Wollny, Faldum, & Sorensen, 2002), all of which interfere with psychosocial function and academic QoL (Cohen et al., 2011).