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Adult Ocular and Orbital (Ocular Adnexa) Tumors
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
P.N. Plowman, Rachel Lewis, J.L. Hungerford
Vascular tumors predominantly affect the orbit. In the adult, cavernous hemangioma is one of the most common primary orbital tumors. It usually presents in middle-aged women and is best managed by surgical resection via a lateral orbitotomy.
Oncology
Published in Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss, Understanding Medical Terms, 2020
Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss
One of the most common sites for both primary and metastatic tumors is the liver. Primary tumors of the benign type include cavernous hemangioma (hem-, meaning "blood"; angi-, meaning "vessel"; plus -oma, "tumor"), focal nodular hyperplasia, hepatic cell adenoma (aden-, "gland"), and infantile hemangioendothelioma (endothel-, arising from linings of the blood vessel). The most prevalent malignant tumor of the liver is hepatocellular (hepato-, "liver") carcinoma (HCC). In children it is a hepatoblastoma. Others occurring less frequently are intrahepatic cholangiocarcinoma, angiosarcoma, epithelioid hemangioendothelioma, and undifferentiated sarcoma.
Diseases of the Hepatobiliary Tree and Pancreas Associated with Fever
Published in Benedict Isaac, Serge Kernbaum, Michael Burke, Unexplained Fever, 2019
Benign tumors — Benign tumors are frequently asymptomatic and rarely attended by fever. However there have been a few reports in the literature of benign liver tumors presenting with fever. Hepatocellular adenoma may occasionally undergo infarction or hemorrhage and be manifested by the sudden onset of abdominal pain, nausea, vomiting, fever, and leukocytosis. Such features occurred in three out of 75 cases reported from the United States Armed Forces Institute of Pathology.166 A young female with FUO was subsequently found to have an adenoma of the liver secondary to birth-control pill ingestion.157 Cavernous hemangioma usually presents as an abdominal mass with or without pain. Sometimes, fever168 and chills are the predominant manifestations. Fever persisting after inability to resect the tumor at laparotomy has been controlled by radiotherapy169 or prednisone.170 Mesenchymal hamartoma was found in a 19-year-old female, who presented with abdominal pain, fever, jaundice, and hepatomegaly, and who was initially thought to have a hepatic abscess.171 Leiomyoma of the liver was found at autopsy of an 87-year-old female who succumbed after developing hematemesis, epigastric pain and fever.166
Modified vertical lid split orbitotomy: a case series and literature review
Published in Orbit, 2023
Jacqueline H. C. Tai, Kenneth K.H. Lai, Andrew K.T. Kuk, Edwin Chan, Callie K. L. Ko
A total of four (female = 3) patients with intraconal orbital lesions underwent modified VLS orbitotomy. The average age was 49.3 standard deviation ±11.8 years old (range: 35–65). One case with deep intraconal lesion inferonasal to the optic nerve underwent modified VLS for both upper and lower lids with medial rectus disinsertion in the same setting. All four cases were diagnosed with cavernous hemangioma histologically. The surgical outcomes are summarized in Table 1. All four patients were satisfied with their cosmesis at 3 months post surgery (Figure 3). Regarding complications of this technique, only one patient suffered from significant long-term complication with postoperative ptosis and restricted extraocular movement. Otherwise, patients had satisfactory postoperative extraocular movement.
Sirolimus-induced regression of a large orbital lymphangioma
Published in Orbit, 2019
Wolf A. Lagrèze, Lutz Joachimsen, Nikolai Gross, Christian Taschner, Jochen Rössler
A 23-year-old male patient was referred for surgical removal of a retrobulbar lesion in his right orbit, which had slowly evolved over the last previous years. The referral diagnosis was a suspected “cavernous hemangioma”. His right eye showed 11 mm exophthalmos (Figure 1, Panels A and C), mild chorioretinal folds, a visual acuity of 20/30, and a minor restriction of up-gaze. As opposed to his referral diagnosis, a revision of his magnetic resonance images revealed a retrobulbar, microcystic lymphangioma in the muscle cone (Figure 1, Panel C). Surgical removal was disregarded. Instead, we decided to initiate an experimental off-label treatment with sirolimus (rapamycin) antagonizing the mTOR (mechanistic target of rapamycin) pathway. The patient was put on therapy with oral sirolimus 1 mg twice a day. Sirolimus blood levels were maintained between 5 and 10 ng/mL. Within six months of treatment, the lymphangioma had clinically as well as radiologically largely regressed to a remaining exophthalmos of 2 mm (Figure 1, Panels B and D). The patient did not complain of any side effects.
A giant hemangioma of the sigmoid colon as a cause of lower gastrointestinal bleeding in a young man
Published in Baylor University Medical Center Proceedings, 2022
Lucas Fair, Benjamin Gough, Adatee Oknokwo, Ronney Stadler
The recommended treatment of cavernous hemangioma of the GI tract is surgical resection. This can be achieved via a laparoscopic, robotic, or open approach. Nonoperative therapy is limited. Local control of bleeding has been described, but has had limited success. Ligation of the arteries feeding the lesion has been attempted, but this technique appears unreliable as subsequent bleeding has occurred.8–10 There have been case reports of successful endoscopic management. In one case, a small, pedunculated hemangioma was managed endoscopically using snare polypectomy and electrocautery.10