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Cysts and Tumours of the Bony Facial Skeleton
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Julia A. Woolgar, Gillian L. Hall
AF is a rare, benign neoplasm of both odontogenic epithelium and ectomesenchyme.72, 73 The presence of dentine or other dental tissues leads to the designation ameloblastic fibro-dentinoma73 (AFD) and ameloblastic fibro--odontoma (AFO),73, 74 respectively.
Bone, Muscle, and Tooth
Published in Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath, Page R. Bouchard, Toxicologic Pathology, 2018
John L. Vahle, Joel R. Leininger, Philip H. Long, D. Greg Hall, Heinrich Ernst
All dental tissues are found, including ameloblastic epithelium, stellate reticulum-like cells, enamel matrix, enamel, dentin, odontoblasts, cementum, cementoblasts, and pulpal tissue. The hard dental structures are usually located in the central areas of the tumor. Degenerating, keratinized, and calcified odontogenic epithelium (“ghost cells”) may also be observed. Formation of reactive multinucleated giant cells within the tumor tissue in response to accumulation of keratin debris may occur. One variant (ameloblastic fibro-odontoma) exhibits substantial proliferation of fibroblasts in association with the tissues derived from teeth. Ameloblastic odontomas tend to be locally aggressive (invasive and destructive) but do not metastasize. They have been reported to occur following administration of N-butylnitrosourea (Wang et al. 1975). Similar “odontogenic tumors” have been observed in genetically altered mice carrying albumin-myc (Alb-Myc) and albumin-ras (Alb-Ras) transgenes.
Ameloblastic Fibro-Odontoma
Published in Fetal and Pediatric Pathology, 2023
Moeinadin Safavi, Farnoosh Mohammadi
Microscopic examination of the lesion revealed cords and nests of odontogenic epithelium with peripheral palisading in a loose myxoid stroma resembling dental pulp. There was also a disorganized component of dentin, enamel, and cementum adjacent to the odontogenic epithelial component (Fig. 2). These findings were that of an ameloblastic fibro-odontoma.