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Use of Dermatologics during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Striae gravidarum, or stretch marks, may be especially unsettling to pregnant women. Numerous creams and ointments (including “mink oil” or vitamin E) are available in the over-the-counter market to treat stretch marks. However, there is no medical therapy known to be effective. Most striae, which are hyperemic during pregnancy, will diminish in appearance (often becoming small, silvery lines). Most patients simply require reassurance.
Pregnancy and Skin Disease
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Tugba Kevser Uzuncakmak, Ozge Askin, Yalçın Tüzün
Overview: During pregnancy, stretch marks, also called striae gravidarum, may occur due to hormonal factors, genetic predisposition, and mechanical stress. Striae occur in 60–90% of pregnant women and represent one of the most common skin findings of pregnancy. Contributing factors include the weakening of the connections between collagen fibers in areas of tension, such as breasts, abdomen, and hips. With the effect of increased corticosteroids, estrogen, and relaxin, the elastic fibers in the reticular dermis may rupture or fracture. Striae rubrae, which are clinically pink to purple, linear bands, develop and can later become ivory-colored, atrophic lesions, known as overtime, but they do not disappear completely. Striae development is known to occur more frequently in young primiparous women with a high body-mass index, plus excessive weight gain during pregnancy, carrying macrosomic babies, and a personal or family history of striae.
Prenatal Care
Published in Vincenzo Berghella, Obstetric Evidence Based Guidelines, 2022
Gabriele Saccone, Kerri Sendek
Some stretch marks (striae gravidarum) develop in about 50% of women by the end of pregnancy. There is no high-quality evidence to support the use of any topical preparation in the prevention of stretch marks during pregnancy [133, 134]. There is also no proven treatment for stretch marks once they have developed [134]. Olive oil is not effective in preventing the occurrence of striae gravidarum or affecting its severity [134]. There is no available product that has been shown to prevent the formation of striae gravidarum. Massage with either Trofolastin cream or Verum ointment is associated in small RCTs with a decrease in the development of striae gravidarum [134]. A small, randomized trial showed that a specific anti–stretch mark cream (emollient and moisturizer containing hydroxyprolisilane C, rosehip oil, Centella asiatica triterpenes, and vitamin E) had a small effect in reducing severity (but not the incidence) of striae gravidarum during pregnancy (see Chap. 45 in Maternal-Fetal Evidence Based Guidelines) [135].
Striae gravidarum and different modalities of therapy: a review and update
Published in Journal of Dermatological Treatment, 2022
Yangyiyi Yu, Haijing Wu, Heng Yin, Qianjin Lu
Striae distensae (SD) is caused by various risk factors, including pregnancy, weight gain or loss, and corticosteroid overdose (1,2). The term striae gravidarum (SG) refers to a kind of SD that develops particularly during pregnancy. Almost 60–90% of women suffer from SG (3,4). It typically appears on the abdomen, with less frequent appearance on the breasts, back, buns, and proximal extremities. In the early stage, lesions are dark red or purplish red – giving the condition the name striae rubra (SR) – and may be edematous or pruritic. The lesions then become discolored, flabby, and atrophic, and finally mature into white or silvery wrinkled paper-like streaks, which are called striae alba (SA) (2).