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Cushing's Syndrome/Hypercortisolism
Published in Charles Theisler, Adjuvant Medical Care, 2023
Cushing’s syndrome most often affects adults aged 30–50, but can also occur in children. Too much cortisol, whether originating from long-term, high-dose corticosteroid use, adrenal gland tumors, certain types of cancer, or the result of a pituitary adenoma secreting ACTH (adrenocorticotropin), typically causes weight gain and fatty deposits. The hallmark signs of Cushing’s syndrome are a fatty hump between the shoulders and obesity of the face, neck, and abdomen while the limbs remain comparatively thin. Purple stretch marks are common, especially on the abdomen. Symptoms include extreme fatigue, muscle weakness, anxiety, irritability, and loss of emotional control. Three times more women are affected than men.
Use of Dermatologics during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Striae gravidarum, or stretch marks, may be especially unsettling to pregnant women. Numerous creams and ointments (including “mink oil” or vitamin E) are available in the over-the-counter market to treat stretch marks. However, there is no medical therapy known to be effective. Most striae, which are hyperemic during pregnancy, will diminish in appearance (often becoming small, silvery lines). Most patients simply require reassurance.
Pregnancy and Skin Disease
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Tugba Kevser Uzuncakmak, Ozge Askin, Yalçın Tüzün
Overview: During pregnancy, stretch marks, also called striae gravidarum, may occur due to hormonal factors, genetic predisposition, and mechanical stress. Striae occur in 60–90% of pregnant women and represent one of the most common skin findings of pregnancy. Contributing factors include the weakening of the connections between collagen fibers in areas of tension, such as breasts, abdomen, and hips. With the effect of increased corticosteroids, estrogen, and relaxin, the elastic fibers in the reticular dermis may rupture or fracture. Striae rubrae, which are clinically pink to purple, linear bands, develop and can later become ivory-colored, atrophic lesions, known as overtime, but they do not disappear completely. Striae development is known to occur more frequently in young primiparous women with a high body-mass index, plus excessive weight gain during pregnancy, carrying macrosomic babies, and a personal or family history of striae.
Evaluation and efficacy of carbon dioxide therapy (carboxytherapy) versus mesolipolysis in the treatment of cellulite
Published in Journal of Cosmetic and Laser Therapy, 2018
Fatma Eldsouky, Howyda Mohamed Ebrahim
Carbon dioxide therapy (Carboxytherapy) is the CO2 gas injected under the skin for therapeutic benefits. The gas diffuses into the tissues causing blood vessels dilatations with subsequent gush of oxygen and nutrients to the treated area. Previous studies have demonstrated its effectiveness in treatment of stretch marks, dark circle, and in skin rejuvenation (5,6).The technique has been used in France since1932, and was conducted by applying water-saturated CO2 to treat skin ulcer. Application of carboxytherapy in cellulite treatment was recently reported. Few studies described the effectiveness of the carboxytherapy in the treatment of localized fat deposit. Carboxytherapy has a vasodilator effect on the microcirculation, and it enhances the blood flow in the adipose tissue and increases the skin temperature (7–9). Mesolipolysis is a noninvasive technique; it involves injection of active ingredients into localized fat deposit to dissolve it. Mesolipolysis increases fat metabolism and improves lymphatic circulation that helps in its excretion by kidneys (10,11). It improves microcirculation, eliminates toxic materials and tissue edema, and increases lipolysis. Moreover, it improves the skin texture by stimulation of fibroblast activity (12,13).
Development of a combination therapy with silanols complexed with boron citrate and ablative-fractional laser for treatment of wrinkles and stretch marks
Published in Journal of Dermatological Treatment, 2021
Klaudyna Wolak, Roksana Gruszkiewicz-Majczak
Stretch marks are a common problem, affecting 55–90% of women especially in the gestational period, and can also occur in men (6). This atrophic dermal scars are often found on abdomen, breasts, thighs, and hips of pregnant women and people which get weight gain in a short period of time (7). The changes have the form of linear, atrophic longitudinal scar-like lesions that appear parallel to the skin’s tension line. A the beginning they appear in the form of pink-red lines, which then become raised, get longer, wider and purple-red. Within a few months to several years, the traces fade and become hypopigmented (so-called white stretch marks) (8).
Striae gravidarum and different modalities of therapy: a review and update
Published in Journal of Dermatological Treatment, 2022
Yangyiyi Yu, Haijing Wu, Heng Yin, Qianjin Lu
During pregnancy, the expression of hormone receptors and levels will also change dramatically. The expression of estrogen receptor within stretch marks is almost twice as high as that of normal skin. Androgen and glucocorticoid receptor expression are also increased (18). The surge of glucocorticoids inhibits the activity and proliferation of fibroblasts and reduces the number of elastic fibers and collagen synthesized by these cells, thereby preventing the complete repair of damaged connective tissue in the dermis (19).