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Glassy cell carcinoma
Glassy cell carcinoma is a type of cancer that is uncommon and is characterized by poorly differentiated adenosquamous carcinoma. It is typically found in the uterine cervix.From: Tumor Diagnosis 2Ed [2019]
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Hematogenous spread of disease is relatively unusual and most frequently involves the lungs, bones, intraabdominal viscera, or distant lymphatics.25 One study indicated that patients with hematogenous metastasis had a 5.3-fold higher risk of death compared to those with lymphatic metastasis.26 Variant cell types, such as neuroendocrine or glassy cell carcinoma, may be associated with distant disease in the absence of local spread. Current therapy for these variants typically involves multimodality strategies designed to address the tumor’s potential for local and distant metastasis.27,28
Mixed adenosquamous carcinomas are rare (including glassy cell carcinoma). Neuroendocrine tumors include small and big cell carcinomas. They are extremely aggressive, and their diagnosis can be confirmed with neuroendocrine markers.
Primary vaginal malignancies: a single oncology centre experience
SCC was the most frequent histological subtype and accounted for 27 cases (77.1%), followed by adenocarcinoma that corresponded to 5 cases (14.3%). Glassy cell carcinoma, melanoma and botryoid sarcoma occurred as isolated cases.