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Benign Neoplasms
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Abdullah Demirbaş, Ömer Faruk Elmas, Necmettin Akdeniz
Differential diagnosis: Glomeruloid hemangiomas seen in polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin lesions (POEMS) syndrome, angiokeratoma, pyogenic granuloma, and angiosarcoma can be considered. POEMS syndrome is a rare multisystemic condition that occurs in the setting of plasma cell dyscrasia.
The Non-Hodgkin’s Lymphomas and Plasma Cell Dyscrasias
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Lynne V. Abruzzo, L. Jeffrey Medeiros
POEMS syndrome is a rare variant of plasma cell myeloma that occurs in less than 3% of myeloma patients. The syndrome is characterized by: polyneuropathy, organomegaly, endocrine abnormalities, monoclonal spike, and skin changes. Patients with POEMS syndrome differ from patients with typical myeloma in several ways. They are often younger, have osteosclerotic rather than lytic bone lesions, and have an IgA lambda monoclonal protein. The unusual features are believed to result from the abnormal production of cytokines produced by the neoplastic plasma cells.
Case 30
Published in Atul B. Mehta, Keith Gomez, Clinical Haematology, 2017
POEMS syndrome is the association of polyneuropathy with organomegaly, endocrinopathy, a monoclonal gammopathy and skin lesions. The bone marrow aspirate (Figure 30b) shows an increase in plasma cells. Patients with POEMS often have an increased plasma level of vascular endothelial growth factor (VEGF).
Temporal and Spatial Correlation Between Choroidal Thickness and Visual Function in a Case of POEMS Syndrome
Published in Ocular Immunology and Inflammation, 2018
Julio González-Martin-Moro, Inés Contreras, Belén Pilo-de-la-Fuente, Fernando Gómez-Sanz
POEMS syndrome is a rare multisystemic disorder characterized by the presence of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. It usually presents in the fifth or sixth decade and is often due to a plasma cell dyscrasia. Ocular manifestations are common in POEMS syndrome, with bilateral optic nerve swelling being the most frequent ocular presentation. In one of the major series, it was present in 52% of the patients,1 and it is probably an independent prognostic factor.2 Although frequently called “papilloedema,” it is not clear if it is a manifestation of increased intracranial pressure, nerve infiltration, ischemia, or vascular hyperpermeability. Indeed the presence of edema elsewere1 and the response of some cases to antivascular endothelial growth factor (VEGF) agents,3 supports hyperpermeability as the main mechanism for optic disc swelling. Other reported ocular manifestations are cystoid macular edema,3 serous macular detachment, infiltrative orbitopathy,4 venous sinus thrombosis,1 and peripapillary choroidal neovascularization.5,6
POEMS syndrome: origination from clonal plasma cells or B cells?
Published in Hematology, 2023
Lu Zhou, Jinfeng Lu, Zenghua Lin, Xinfeng Wang, Lan Luo, Chenhui Wang, Lemin Hong, Ruirong Xu, Hongmin Huang
POEMS syndrome is a disorder that affects multiple systems. In the early stages, patients may exhibit peripheral neuropathy, ascites, skin changes, and endocrine modifications, which may be misdiagnosed as nervous, digestive, or endocrine diseases. In this case, the patient initially presented with peripheral neuropathy and hyperglycemia and was misdiagnosed as diabetic peripheral neuropathy. Later, he was misdiagnosed with a digestive disease because of a large amount of ascites and was admitted to the Department of Gastroenterology. After multidisciplinary consultation, he was finally diagnosed with POEMS syndrome. As this case shows, POEMS syndrome is easily misdiagnosed. POEMS syndrome should be investigated in patients who have unexplained peripheral neuropathy and ascites.
Living with Polyneuropathy Organomegaly Endocrinopathy Monoclonal gammopathy Skin changes (POEMS) syndrome: a case study of healthcare experiences and quality of life
Published in Disability and Rehabilitation, 2021
Jessica Twigg, Abigail Methley, Tim Lavin, Gemma Dickinson, Alistair Teager
This enables increased insight into the phenomenon of interest by presenting complementary but different aspects [27] Questionnaire data were given context through qualitative findings, whilst qualitative themes were partially categorised by quantitative data. Qualitative data showed that there could be significant influences on mood, even when questionnaire scores were within the subclinical range, suggesting that a broader focus on emotional wellbeing is needed not simply the reduction clinical symptoms. Similarly, the differences across domains of quality of life in the quantitative data are reflected in the qualitative data the participant reported, which described her relationships, environment, physical health and psychological wellbeing, and how, whilst inter-related, wellbeing in each of these domains could differ depending on symptom progression. Quantitative data on illness beliefs relating to the longevity of the condition, perceptions of treatment and control of symptoms, and the emotional impact of the condition, are also reflected in quantitative themes in the three qualitative themes. POEMS Syndrome has been found to differ from other conditions due to the high rate of early misdiagnosis leading to lengthy and inappropriate therapies being trialled. This often causes a median delay of around 12 months [4]. With early diagnosis POEMS Syndrome is potentially curable with a 75% chance of a five-year progression-free survival rate after autologous stem cell transplantation [28]. In this specific case, the participant presented with multiple symptoms (leg fracture and lower limb vascular insufficiency) which could have been missed opportunities in the early diagnosis of POEMS Syndrome.