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Development of Comorbid PTSD and Substance Use Disorders
Published in Anka A. Vujanovic, Sudie E. Back, Posttraumatic Stress and Substance Use Disorders, 2019
Erin C. Berenz, Sage McNett, Katherine Paltell
Further research is needed to be able to evaluate whether and how adolescent alcohol and substance use impacts developmental trajectories in the context of trauma and PTSD risk. In fact, the National Institutes of Health (NIH) have funded two large, multi-site investigations geared toward understanding how alcohol impacts adolescent development, from a variety of methodological perspectives. First, the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) is an NIH-funded, multi-site effort founded in 2012 to evaluate the effects of adolescent alcohol use on developmental trajectories, utilizing state-of-the-art neuropsychological assessments, imaging data, and clinical measures (see Brown et al., 2015 for more information). Second, the Adolescent Brain Cognitive Development (ABCD) Study is a multi-institute, multi-site consortium dedicated to evaluating a range of adolescent exposures, including substance use, in relation to adolescent and young adult development and similarly incorporates multi-method, intensive data collection methods in a large sample of youth (Jernigan, Brown, & ABCD Consortium Coordinators, 2018). Together, data resulting from these enormous efforts will undoubtedly shed light on potential mechanisms underlying PTSD/SUD comorbidity from multiple perspectives.
Ophthalmic Complications in Older Adults with Diabetes
Published in Medha N. Munshi, Lewis A. Lipsitz, Geriatric Diabetes, 2007
Jerry D. Cavallerano, Deborah K. Schlossman, Rola N. Hamam, Lloyd Lloyd
It is clear from these and other studies that hypertension increases the progression of DR and its associated risks. The Appropriate Blood Pressure Control in Diabetes (ABCD) Study demonstrated that reduction of blood pressure even in those normotensive at baseline had an effect on reducing retinopathy complications (142). Tight blood pressure control is a key component of appropriate eye care in diabetic patients. Elderly patients, however, have reduced tolerance for blood pressure reduction and severe hypotensive episodes can lead to injuries and associated morbidity and mortality. Thus, blood pressure targets in elderly diabetic patients need to be tailored to be as optimal as is safe and tolerated for each individual.
Using data science to improve outcomes for persons with opioid use disorder
Published in Substance Abuse, 2022
Corey J. Hayes, Michael A. Cucciare, Bradley C. Martin, Teresa J. Hudson, Keith Bush, Weihsuan Lo-Ciganic, Hong Yu, Elizabeth Charron, Adam J. Gordon
In mirroring funding agency priorities, large-scale addiction-focused studies are integrating data science practices at their core. For example, the Adolescent Brain Cognitive Development (ABCD) Study®, the largest, long-term brain development and child health study in the United States, will follow approximately 12,000 9–10 year old children through young adulthood and gather extensive amounts of and various types of data (e.g., imaging and digital data) about each child as the child progresses through adolescence.22 The current phase of The ABCD Study® can help us understand the effects of substance use on the developing adolescent brain.23 The ABCD Study® has weaved data science into the core of the study by creating a Data Analysis, Informatics, and Resource Center (DAIRC) as a study component. DAIRC is providing data harmonization, central capture, and rigorous data quality controls to publicly share all ABCD data and tools with data scientists from around the world to analyze.24
Suicide Ideation and Neurocognition Among 9- and 10-Year Old Children in the Adolescent Brain Cognitive Development (ABCD) Study
Published in Archives of Suicide Research, 2022
Rebekah S. Huber, Chandni Sheth, Perry F. Renshaw, Deborah A. Yurgelun-Todd, Erin C. McGlade
The Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®) (www.ABCDstudy.org) is a large, multi-site, longitudinal study that follows 9- and 10-year-old children through late adolescence to identify factors that influence developmental trajectories. One of the objectives of the ABCD study is to examine how biology and environment interact and relate to developmental outcomes such as physical health, mental health, and life achievements. Thus, the ABCD study provides data that is well suited for an examination of risk factors for suicide in children as they transition to adolescents and young adults. The present study utilized baseline data from participants in the ABCD study (data release 2.0.1) to examine whether a history of SI was associated with neurocognitive performance. Since little is known about this relationship in children, and only one study of SI and neurocognition during childhood exists (Barzilay et al., 2019), the analytic plan was exploratory and performance across several cognitive domains was examined. Based on previous findings in adolescent and adult studies (Jollant et al., 2005; Keilp et al., 2008, 2013, 2014; Malloy-Diniz et al., 2009; Richard-Devantoy, Berlim, et al., 2015), we hypothesized that children with SI would have lower neurocognitive performance across tasks of attention, memory, and executive function compared to children without SI.
Concordance between substance use self-report and hair analysis in community-based adolescents
Published in The American Journal of Drug and Alcohol Abuse, 2023
Natasha E. Wade, Ryan M. Sullivan, Susan F. Tapert, William E. Pelham, Marilyn A. Huestis, Krista M. Lisdahl, Frank Haist
The ABCD Study is a 21-site, longitudinal study following 11,878 youth from ages 9–10 through 19–20. Recruitment efforts were guided by census data to ensure a diverse and generalizable sample (29). The present analysis evaluates data from Annual Release 4.0 (October 2021; http://dx.doi.org/10.15154/1523041), including data from baseline (Year 0; starting in 2017) through the 3rd annual follow-up visit (including data into 2021). Hair samples and self-reported substance use data were collected by trained research assistants at each site during the same study visit. All participants and their parents/guardians provided written assent/consent, and a centralized Institutional Review Board approved the study.