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Clinical Progresses in Regenerative Dentistry and Dental Tissue Engineering
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
However, all single-colony derived SHED clones tested are capable of inducing bone formation in immunocompromised mice. While SHED could not differentiate directly into osteoblasts, they appeared to induce new bone formation by forming an osteo-inductive template to recruit murine host osteogenic cells (Miura et al. 2003). With the osteo-inductive potential, SHED can repair critical-sized calvarial defects in mice with substantial bone formation (Seo et al. 2008). These findings imply that deciduous teeth may not only provide guidance for the eruption of permanent teeth, as generally assumed, but may also be involved in inducing bone formation during the eruption of permanent teeth.
Growth and development
Published in Jagdish M. Gupta, John Beveridge, MCQs in Paediatrics, 2020
Jagdish M. Gupta, John Beveridge
1.44. Which of the following statements concerning teething is/are correct?A 1-year-old infant is likely to have six to eight deciduous teeth.The first deciduous tooth to erupt is an upper central incisor.There are 20 deciduous teeth.One of the first permanent teeth to erupt is a lower central incisor.Calcification of the first permanent molars begins at birth in a full-term infant.
Hypophosphatasia
Published in William L. Nyhan, Georg F. Hoffmann, Aida I. Al-Aqeel, Bruce A. Barshop, Atlas of Inherited Metabolic Diseases, 2020
In patients with hypophosphatasia first seen after the seventh month of life and throughout childhood, the disease may be less severe. There are, nevertheless, generalized skeletal abnormalities. It is characterized by premature loss of deciduous teeth [17–19]. Other dental problems include dental hypoplasia and marked dental caries. Craniostenosis is a common sequel in these infants. Premature synostosis occurs in the presence of uncalcified osteoid [20]. Exophthalmos and increased intracranial pressure may ensue. The roentgenogram of the skull may assume a beaten silver appearance [21, 22]. Convulsions, brain damage, or even death may be complications in the absence of surgical decompression. Walking is often delayed and awkward. The lower extremities may be bowed or there may be genu valgum. These patients may have retarded growth and increased susceptibility to infection. Roentgenograms reveal irregular epiphyses and radiolucencies in the bony shafts. There may be features suggestive of rickets with costochondral beading and widening of the ends of the bones, as well as the bowing deformity but, on X-ray, the ends of the bones have a notched appearance very different from the cupping of rickets and more like that of a metaphyseal dysplasia. The occurrence of subperiosteal new bone formation also distinguishes this picture from that of rickets [23]. There is considerable variation in severity among these patients. In fact, some have been observed in whom premature loss of the anterior deciduous teeth was the only evidence of disease [18, 19, 24].
Diversity of site-specific microbes of occlusal and proximal lesions in severe- early childhood caries (S-ECC)
Published in Journal of Oral Microbiology, 2022
Kausar Sadia Fakhruddin, Lakshman Perera Samaranayake, Rifat Akram Hamoudi, Hien Chi Ngo, Hiroshi Egusa
This phenomenon may be due to the anatomical and structural differences of the occlusal and proximal surfaces of deciduous teeth and/or the intrinsic ecological differences in these two localities. For instance, the occlusal niches are constantly exposed to the ebb and flow of saliva with its arsenal of immune challenges and the masticatory forces due to the intermittent food intake accompanied by incessant tongue movements. Further, it has a much more dynamic environment than the proximal niches in between teeth, which are more sedate and well protected from such extrinsic stresses [8,41]. In addition, the sheltered proximal cavitated locales are almost unreachable to routine oral hygiene measures [8,41], although appliances such as interdental brushes may reach such regions. Thus, it is tempting to speculate that the inherent features overarching the proximal and distal caries ecosystems may be the critical reasons for the significant diversity in the microbiota of these two sites.
Effectiveness and safety of Bifidobacterium in preventing dental caries: a systematic review and meta-analysis
Published in Acta Odontologica Scandinavica, 2021
Siyuan Hao, Jiahe Wang, Yan Wang
A qualitative description was made because the two studies conducted by Taipale et al. used DMF (Decayed, Missing, Filled) [32] and International Caries Detection and Assessment System (ICDAS), respectively, for assessments [33]. Taipale et al. respectively administered Bifidobacterium or sorbitol (placebo) to 55 and 54 infants with an average duration of 14.9 months, from 1 to 2 months of age, through a sustained-release pacifier or tablet [32]. When examined at 8 months and 2 years of age, the deciduous teeth of both groups had a DMF of 0. Taipale et al. also followed up the children and re-evaluated them when they were four years old, using the ICDAS, to assess the incidence of deciduous tooth decay in 32 children in the test group and 29 in the control group [33]. The results revealed that the incidence of enamel caries (ICDAS code 2–3) and significant dentine caries (ICDAS code 4–6) in the test group was even higher than that in the control group, but it did not reach a statistically significant difference.
Effects of graphene oxide and graphene oxide quantum dots on the osteogenic differentiation of stem cells from human exfoliated deciduous teeth
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Xin Yang, Qi Zhao, Yijing Chen, Yuanxiang Fu, Shushen Lu, Xinlin Yu, Dongsheng Yu, Wei Zhao
The cells from human exfoliated deciduous teeth were taken from 6- to 10-year-old children whose caries-free deciduous teeth required extraction. Ethics Committee approval was provided by the School of Stomatology, Sun Yat-sen University. Briefly, the teeth were placed in pre-cooled phosphate-buffered saline (PBS, Hyclone, Logan, UT, USA) with 1% penicillin/streptomycin (P/S; Gibco, Thermo Fisher Scientific, Inc., GrandIsland, NY, USA ) and taken to the laboratory within 8 h of extraction. Pulp tissue was extracted with a barbed broach, cut into pieces and digested with 1:1 3 g/l collagenase type I (Sigma-Aldrich, St. Louis, MO, USA) and 4 g/l dispase (Roche, Basel, Switzerland) at 37 °C for 30 min. The pulp cells were then suspended in the primary culture medium, which included Dulbecco’s modified Eagle’s medium (DMEM; Gibco), 20% foetal bovine serum (FBS; Gibco), and 2% penicillin/streptomycin, then cultured in 37 °C and 5% CO2 incubator.