China
Africa
Explore chapters and articles related to this topic
Posterior Skull Surgery in Craniosynostosis
Published in Niall MH McLeod, Peter A Brennan, 50 Landmark Papers every Oral & Maxillofacial Surgeon Should Know, 2020
The surgical management of raised intracranial pressure and abnormal head shape in craniosynostosis has focused on interventions that increase the cranial vault volume to allow the brain space to develop. Historically, procedures that addressed the anterior part of the skull (such a fronto-orbital advancement and remodelling) were utilised predominantly.
Composite Materials for Oral and Craniofacial Repair or Regeneration
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Teresa Russo, Roberto De Santis, Antonio Gloria
An ideal scaffold should promote bone regeneration and also target the process to certain regions. In particular, it should be advantageous for surgical correction of craniosynostosis in encouraging the formation of cranial bone tissues, while preventing resynostosis (Fedore et al. 2017). Furthermore, medical imaging data would allow for precise and customized replication of the architecture of the skull and bony defect, in a combined approach of RE and AM (Chim and Schantz 2005), thus simplifying surgical placement and retention.
Hypophosphatasia
Published in William L. Nyhan, Georg F. Hoffmann, Aida I. Al-Aqeel, Bruce A. Barshop, Atlas of Inherited Metabolic Diseases, 2020
A number of treatments have been tried without convincing benefit. Phosphate supplementation has been employed [57]. It is usually necessary to correct craniosynostosis surgically. The usual measures are employed for the management of fractures and skeletal deformities. Dental interventions are often necessary. Nonsteroidal anti-inflammatory agents may be useful for bone pain and stress fractures.
Cognitive Development in Single-Suture Craniosynostosis – A Systematic Review
Published in Developmental Neuropsychology, 2023
K Olsson, J Engman, D Nowinski, M Ramklint, M.A Frick
Craniosynostosis (CS) is a congenital condition in which the sutures of the cranial bones in the developing infant have fused in utero, restricting and altering the growth of the skull. The condition affects approximately one in every 1.300 to 2,500 births (DiRocco et al., 2009; Lee et al., 2012; Tarnow et al., 2022). Depending on the number and location of affected cranial sutures, the condition can be subdivided into single-suture (SSC) or complex CS. SSC affects either sagittal, metopic, unicoronal or lambdoid sutures (Governale, 2015), while complex CS signifies multi-sutural fusion and/or association with a craniofacial or genetic syndrome. Approximately 200 genetic conditions have been identified as involved in the etiology of CS, but a vast number of cases are still classified as non-syndromic craniosynostosis (NSC) without an as of yet identified genetic cause (Lee et al., 2012; Tarnow et al., 2022). In recent years, significant advances have been made with regards to genetic screening in the field and many cases formerly labeled NSC have been found to have a genetic cause though not yet deemed syndromic in nature and scope (Timberlake et al., 2019). However, empirical studies frequently simply refer to the condition as SSC without reference to a putative cause, a term which will be used in the present review since it is still the most inclusive and widespread term referring to the patient group of interest.
Initial UK series of endoscopic suturectomy with postoperative helmeting for craniosynostosis: early report of perioperative experience
Published in British Journal of Neurosurgery, 2023
Jonathan Halim, Adikarige Silva, Curtis Budden, David J. Dunaway, N. U. Owase Jeelani, Juling Ong, Greg James
Minimally invasive treatments for craniosynostosis have grown in popularity owing to the ability to negate some of these complications. The risk of rapid sutural refusion associated with early suture release surgeries was negated by the use of external orthoses, internal springs and distractors. These treatments utilise the concept of a rapidly developing and growing neonatal brain to correct the congenital deformity early in infancy. The endoscopic approach was pioneered by Barone and Jimenez6 and is associated with significant reductions in blood loss and the need for transfusions, smaller incisions, shorter surgical times and hospital stays with acceptable long-term anthropometric outcomes since it is performed early in life.7–11 Careful analysis of their outcomes over the last 17-years indicates excellent and long-lasting results,12 and their data has been supported by others.13,14
Early Prenatal Ultrasound and Molecular Diagnosis of Apert Syndrome: Case Report with Postmortem CT-Scan and Chondral Plate Histology
Published in Fetal and Pediatric Pathology, 2022
Gabriele Tonni, Gianpaolo Grisolia, Maurizia Baldi, MariaPaola Bonasoni, Vladimiro Ginocchi, Liliam Cristine Rolo, Edward Araujo Júnior
A 36-year-old mother, gravida 2, para 1, with a previous uneventful pregnancy, underwent routine second trimester scan at 19 weeks of gestation using both a Voluson E6 (GE, Milwaukee, WI) and a Samsung WS80A (Seul, South Corea) apparatuses equipped with a transabdominal 2 D/3D multifrequency 2.5-5.0 MHz probes. A premature closure of the cranial sutures together with a wide metopic suture and bregmatic fontenelle and turribrachicephaly was seen by both 2D and 3D ultrasound in multiplanar mode and using skeleton mode (Figure 1A,B). Using a gradient light 3 D application called Realistic Vue™, an associated syndactyly of the left hand was clearly detected (Figure 2A,B). The scan revealed features consistent with a presumptive prenatal diagnosis of craniosynostosis. Amniocentesis performed at 20 weeks demonstrated a 46, XX karyotype. The amniotic fluid α-FP level was within the normal range. A genetic panel was performed comprising mutations in FGFR1 (fibroblast growth factor receptor)(exon 8), FGFR2 (exons 8,10), FGFR3 (exon 7), Twist (exon 1).