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Cancer Therapies and Cardiac Dysfunction
Published in Andreas P. Kalogeropoulos, Hal A. Skopicki, Javed Butler, Heart Failure, 2023
Victoria Shklar, Katherine Godfrey, Michelle E. Bloom
Translational medicine has vastly improved our understanding of cancer development and progression and has allowed for the rapid development of new chemotherapy and alternative therapeutic regimens, improving the quality of life and rates of survival in patients with cancer. Early detection and treatment have in many cases transformed cancer from a fatal disease to a chronic condition. Improved cancer survival implicitly uncovers a wide spectrum of toxicities attributable to novel cancer therapies, including those of a cardiac nature. Multidisciplinary care is critical, as cancer outcomes can be influenced by cardiovascular health. In turn, cardiovascular health can influence cancer treatment selection, and cardiac toxicity can impact cancer treatment. Cardiovascular disease (CVD) due to cancer treatment can ultimately alter cancer survivorship.
Translational Challenges
Published in Carla Vitorino, Andreia Jorge, Alberto Pais, Nanoparticles for Brain Drug Delivery, 2021
Bárbara Rocha, Nelson Pacheco Rocha, Bruno Gago
The concept of translational medicine was first mentioned in the 1990’s - but only gained consistency in the early 2000’s-as a consequence of the urgency to optimise drug development processes and transform laboratory findings in useful clinical tools. Translational medicine is generally recognised as a multidisciplinary branch of biomedical research which aims to transfer basic research knowledge to clinical practice - from bench-to-bedside - to improve diagnosis, treatment, and prevention of human disease [1]. In the process, findings from molecular biology are applied in the discovery of novel treatment strategies and integrated within clinical trials, leading to the introduction of therapeutic innovation in a continuous bidirectional flow of information.
Diabetes and Phytopharmaceuticals: Translational Pharmacology Perspective
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Priyanka Ingle-Jadhav, Trupti Rajkumar Angolkar, Ginpreet Kaur
Translational medicine can help bridging the gap between the basic research and public health demands, by converting the discoveries to applications. Current research trends have their own drawbacks leading to pitfalls in current regimen of managing diabetes. Translation research can help in pulling together the scientific discoveries on bench in phytopharmaceuticals to the bedside of patient by personalizing it for prevention, diagnosis, and treatment. Since translation medicine involves knowledge base from different systems, multi-disciplinary approach and expertise becomes prerequisite for a scientist to work in this field. Developing these skill sets and converging science can help address diabetes—major health concern of India and world.
Glucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancer
Published in OncoImmunology, 2022
Jia Bo Zheng, Chau Wei Wong, Jia Liu, Xiao-Jing Luo, Wei-Yi Zhou, Yan-Xing Chen, Hui-Yan Luo, Zhao-Lei Zeng, Chao Ren, Xiao-Ming Xie, De-Shen Wang
Translational medicine usually refers to the “bench-to-bedside” enterprise of harnessing new knowledge, mechanisms and techniques generated by advances in basic research into new approaches for the prevention, diagnosis and treatment of disease where the end-point is the production of a promising new treatment that can be implemented clinically.40 However, most translational research (54%) of translational research fails, where the most common cause was “lack of efficiency”.41–43 Clinical trial (NCT02044861) of PFKFB3 selective inhibitor seems to have stopped with just 6/19 evaluable patients responding to the drug. The main reason for clinical trial failure usually is human subjects not responding to the drug the way laboratory animal models do, which is usually true for fields like immuno-oncology, where truly translatable animal models are often lacking.44 This seems to be underlined by the fact that more and more studies are making the connection between cancer cell metabolism and their immune evasion ability.45–48
Medical and Psychiatric Challenges to Successful Aging
Published in Psychiatry, 2020
How could we avoid Sir William’s fatalism and still be honest in our presentation of the ailments of old age, both psychiatric and medical? The method we chose was to present the medical conditions in an amalgam of translational and narrative medicine. Translational medicine represents an approach which integrates basic science, clinical medicine, and the psychosocial environment. As became evident during the conference, the translation fails all too often, but when it succeeds, the benefits for seniors are satisfying indeed. Narrative medicine explores ways of presenting medical (and psychiatric) conditions as Sir William would have wanted: patient first, disease second. The term “biopsychosocial” is actually backwards: we should consider the “sociopsychobiological” continuum as we confront our patients.
A review of translational medicine. The future paradigm: how can we connect the orthopedic dots better?
Published in Current Medical Research and Opinion, 2018
Mohamed Mediouni, Daniel R. Schlatterer, Henning Madry, Magali Cucchiarini, Balwant Rai
The varied nature and growing number of TM centers exemplifies the contingent and competitive character of science and technology funding streams in the USA. These institutions partner with the best universities yet remain distinct organizational entities, all in an attempt to limit the bureaucracies that stagnate most conglomerations. This ecosystem of collaboration produces a center of “facts on the ground”. New information and ideas are exchanged locally in a time efficient manner bypassing periodical subscriptions and the inefficiencies of traveling to meetings and conventions. The use of innovation to study and understand the complexity of biology represents the major trend in translational medicine. To create a network between scientists and Surgeon, there are many start-ups such as: TIES, Diamond and O3DC.