China
Africa
Explore chapters and articles related to this topic
Emblicanin-A and Emblicanin-B: Pharmacological and Nano-Pharmacotherapeutic Perspective for Healthcare Applications
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Mohamad Taleuzzaman, Debarshi Kar Mahapatra, Dipak Kumar Gupta
The phenolic constituents of P. emblica are not as effective as single but its nanoemulsion formulation for the topical administration showed a good result. The microemulsion technique was used for the preparation of nanoemulsion with hot high-pressure homogenization. The nanoemulsion was optimized by the ternary phase diagram. The formulation is composed of isopropyl myristate (0.6% w/w) and median particle size of 191.63 ± 4.07 nm with a narrow particle size distribution, a ZP of −10.19 ± 0.54 mV. High entrapment efficiency at 67.99 ± 0.87% and good stability at 4°C after 90 days of storage have been seen. From the nanoemulsion, the release of active drug was higher as compared to the aqueous formulation.38
Nanomedicines for Ocular NSAIDs: State-of-the-Art Update of the Safety on Drug Delivery
Published in Lajos P. Balogh, Nano-Enabled Medical Applications, 2020
Joana R. Campos, Joana Araújo, Elisabet Gonzalez-Mira, Maria A. Egea, Elena Sanchez-Lopez, Marta Espina, Selma B. Souto, Maria L. Garcia, Eliana B. Souto
There was reported the use of NE to deliver the poorly water-soluble drugs into corneal segment giving delayed and sustained release, but this can ascribed to their droplets that act as drug reservoir and remains unaffected by the lachrymal fluid. Nevertheless, a formulation having positive surface charge will be able to bind more specifically to the corneal membrane through electrostatic interaction [44]. There is a promising and successful utilization of nanoemulsion-based ONS. The selection of suitable cationic material for the effective formulation composition is necessary when targeting to ocular sites [162].
Dermal and Transdermal Drug Delivery Systems
Published in Tapash K. Ghosh, Dermal Drug Delivery, 2020
Kenneth A. Walters, Majella E. Lane
With increasing interest in nanotechnology, the application of nanoemulsions or microemulsions (classified according to emulsion droplet size) to promote dermal delivery of actives has been explored. These systems are thermodynamically stable, colloidal drug delivery vehicles. Recent reviews on nanoemulsions and microemulsions have highlighted their favorable aesthetic and biophysical properties (Sonneville-Aubrun et al., 2004) as well as their potential to promote dermal delivery of actives (Schwarz et al., 2012). At the present time no commercial nanoemulsion or microemulsion for topical application is available. One reason for this is most likely the cost of the surfactants required for these formulations. Concerns have also been raised about the possible irritation potential of such formulations because of the high surfactant content compared with conventional formulations (Santos et al., 2008).
Development and optimization of drug-loaded nanoemulsion system by phase inversion temperature (PIT) method using Box–Behnken design
Published in Drug Development and Industrial Pharmacy, 2021
Manish Kumar, Ram Singh Bishnoi, Ajay Kumar Shukla, Chandra Prakash Jain
The majority of drugs and bioactive food components are hydrophobic in nature, so they are difficult to deliver in systemic circulation due to dissolution problems in gastrointestinal fluid and also pose several problems during their formulation development [1–3]. For the delivery of such compounds, a nanoemulsion system (lipid-based drug delivery system) is widely used by researchers [4–6]. Nanoemulsion is colloidal dispersion which comprises an internal phase having droplet size ranging from 10 to 200 nm. An oil in water (O/W) nanoemulsion has a nano-size droplet of oil as an internal phase, in which the hydrophobic drugs are solubilized which increases the bioavailability of solubilized drugs [7]. The oil component of the nanoemulsion system also facilitates the lymphatic transport of solubilized drugs after oral administration which leads to bypass the hepatic circulation and first-pass metabolism of the drug are minimized. This further increases bioavailability of drugs delivers through the nanoemulsion system [8].
A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis
Published in Drug Delivery, 2021
Soad A. Mohamad, Mohamed A. Safwat, Mahmoud Elrehany, Sherif A. Maher, Ahmed M. Badawi, Heba F. Mansour
Droplet size is an important characteristic for evaluation of the stability of nanoemulsion and improvement of drug bioavailability (Xi et al., 2009). It is an essential factor since it influences the drug release and biological absorption (Parul et al., 2013). Depending on the appearance, viscosity and entrapment results, F1, F2 and F3 were selected for this investigation. The mean droplet size, polydispersity index and zeta potential of these formulations are displayed in Table 3. F3 demonstrated the smallest droplet size (85.2±0.2nm) while F1 showed the largest one (149±2nm). F2 and F3 had the lowermost values of PDI (0.44±0.02 and 0.35±0.0 respectively) while F1 exhibited a PDI value of 0.78±0.01. Zeta Potential ranged from −20.8 to −29.7mV with F2 having the highest value. The electrical conductivity values ranged from 0.00 to 0.02 mS/cm. Thus, F2 and F3 were selected for following investigations.
Design and development of spirulina polysaccharide-loaded nanoemulsions with improved the antitumor effects of paclitaxel
Published in Journal of Microencapsulation, 2020
Manling Du, Zhenjiang Yang, Wenping Lu, Bingyue Wang, Qi Wang, Zhen Chen, Lianyu Chen, Shuyan Han, Tiange Cai, Yu Cai
The anti-tumour effect of SPS-NEs in combination with PTX was studied in mice bearing S180 cells (Figure 4(A)). The change in mouse body weight is an important index for assessing systemic adverse effects. The body weight of the S180 model mice in the control, PTX, PTX + SPS, as well as the PTX + SPS-NEs groups increased to some extent with time (Figure 4(B)), which indicating that administration of the PTX or SPS did not cause any gross biological toxicity. The antitumor efficacy was evaluated by measuring the changes in the tumour volume and final tumour weight during the experiment. The tumour growth of PTX + SPS-NEs group was slowest, which exhibited significantly effect on tumour growth inhibition (Figure 4(C)). At sacrifice, compared with the control group, the PTX, PTX + SPS and PTX + SPS-NEs treated groups showed significantly inhibited tumour growth with tumour inhibited by 39.17%, 54.28%, and 72.82% (w/w), respectively (Figure 4(D)). Thus, the anticancer effect of PTX + SPS-NEs appears to be more pronounced than that of PTX + SPS. The droplet size of nanoemulsion falls within the colloidal dispersion range. Furthermore, the nanoemulsion has the ability to accumulate in the pathological region of defective blood vessels and has biocompatibility (Li et al.2017; Singh et al.2017). Therefore, the significant anticancer effect of PTX + SPS-NEs is likely to be related to the higher accumulation and longer retention of SPS-NEs in tumour tissues.