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Canker Sores /Recurrent Aphthous Stomatitis (RAS) / Oral Aphthosis
Published in Charles Theisler, Adjuvant Medical Care, 2023
Vitamin B12: Due to the relationship between RAS and vitamin deficiencies, some authors have reported that treatment with vitamin B12, apart from being simple, inexpensive, and of low risk, proves effective in application to RAS, even independently of the serum vitamin B12 levels of the patient.14 Other investigators have reported similar results.15 Vitamin and mineral deficiency replacement is a front-line treatment strategy.16
Weaning a Baby onto a Vegan Diet
Published in Mary Nolan, Shona Gore, Contemporary Issues in Perinatal Education, 2023
Vitamin B12 is best supplemented as a stand-alone supplement as some other nutrients in multi-nutrient supplements can convert up to 90% of the vitamin B12 into inactive analogues (Kondo et al., 1982). This can result in falsely raised levels of serum vitamin B12. The amount of vitamin B12 that can be absorbed from a single dose of supplement is limited, so the amount that needs to be supplemented is much higher than the recommended intake from food.
Biochemical Parameters and Childhood Nutritional Anemia
Published in Anil Gupta, Biochemical Parameters and the Nutritional Status of Children, 2020
The estimation of serum vitamin B12 is necessary in pernicious anemia. This test confirms the low level of cobalamin in patients with anemia. Allen et al. (1990) confirmed that low cobalamin serum levels could not be associated with a deficiency of cobalamin. Therefore, it is necessary to perform an additional test to confirm the cobalamin-deficient patients. The serum methylmalonic acid level rises in vitamin B12 deficiency and its level is normalized after the treatment of the patient with cobalamin supplements.
Clinical role of vitamin D, vitamin B12, folate levels and hematological parameters in patients with sudden sensorineural hearing loss
Published in Acta Oto-Laryngologica, 2023
Nurdan Kose Celebi, Hande Senem Deveci, Semra Kulekci Ozturk, Tugba Aslan Dundar
Low serum vitamin B12 levels are often observed among the elderly population. As is well known, B12 deficiency (B12D) affects the nervous system, and may result in demyelination of neurons of both the peripheral and central nervous systems [10]. In vitamin B12 deficiency, in addition to symptoms of paresthesia, ataxia, and weakness of the limbs; peripheral neuropathy, vocal cord palsy and optic neuropathy are also from time to time observed as neurological abnormalities [11,12]. Studies have shown that SSNHL is associated with iron deficiency and ferritin level. There are a few studies investigating the effects of folate deficiency on auditory function. In their study and found that serum folic acid levels among patients with sudden hearing loss were significantly lower than those in the control group.
The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa
Published in South African Journal of Clinical Nutrition, 2022
CJ Grobler, WH Oldewage-Theron, JM Chalwe
The results in Table 2 demonstrated that the mean ± SD serum vitamin B12 results of group A at baseline was 677 ± 348 picograms per millilitre (pg/ml) with only 7% of the respondents diagnosed as having a deficiency (< 200 pg/ml). The mean ± SD serum vitamin B12 of group B was 679 ± 364 pg/ml with only 2% of the respondents having been diagnosed with a deficiency. The follow-up results indicated that in group A the mean ± SD serum vitamin B12 levels decreased statistically significant (p = 0.000) to 677 ± 304 pg/ml. In group B there was a significant (p > 0.022) increase in the mean ± SD vitamin B12 levels to 705 ± 290 pg/ml. The prevalence of vitamin B12 deficiency (< 200 pg/ml) increased from 7% (baseline) to 12% (follow-up) in group A compared with group B, where it was unchanged at 2%. The difference between group A and B at follow-up was not significant (p > 0.05).
Vitamin B12 deficiency in patients with diabetes at a specialised diabetes clinic, Botswana
Published in Journal of Endocrinology, Metabolism and Diabetes of South Africa, 2021
L Kwape, C Ocampo, A Oyekunle, JC Mwita
This is the first study to estimate the prevalence of vitamin B12 deficiency in a diabetes clinic in Botswana to the best of our knowledge. However, our findings should be interpreted while considering several limitations. We assessed vitamin B12 status using serum vitamin B12 levels. Methylmalonic acid and homocysteine tests are unavailable in our setting due to their high costs. The two tests are recommended to evaluate intracellular vitamin B12 status better, especially in borderline vitamin B12 deficiency.54 Parietal cell and intrinsic factor antibodies status were not correlated with the confirmed vitamin B12-deficient patients to exclude them from this study due to the unavailability of antibody tests in our local setting. The study does not explore the relationship between various factors and vitamin B12 deficiency, including dietary details, a vegan diet, alcohol history, use of multivitamins etc. The duration of metformin use is dependent on the patient’s history and thus subject to recall bias. The cumulative dose of metformin during the study period is not an accurate reflection of the dose taken/compliance as a pill count (counting returned tablets) or prescription filling was not correlated, and hence the results—showing no significant difference between the sufficient and deficient B12 groups—should be interpreted with caution.