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Myositis
Published in Jason Liebowitz, Philip Seo, David Hellmann, Michael Zeide, Clinical Innovation in Rheumatology, 2023
Leukemia, specifically, large granular lymphocytic leukemia (LGLL), has been found in a significant number of patients with IBM,112 raising questions about the exact nature and similarity of the infiltrating CD8+ T cells found in the muscle biopsy with malignant T cells.
The Non-Hodgkin’s Lymphomas and Plasma Cell Dyscrasias
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Lynne V. Abruzzo, L. Jeffrey Medeiros
These neoplasms have been designated previously as T-cell CLL (Kiel and French-American-British classification), Tγ lymphoproliferative disease, and T8 lymphocytosis with neutropenia. There are two subtypes of large granular lymphocyte leukemia (LGLL): the T-cell and natural-killer (NK) cell subtypes.
Principles of Clinical Pathology
Published in Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath, Page R. Bouchard, Toxicologic Pathology, 2018
Niraj K. Tripathi, Jacqueline M. Tarrant
A few animals will develop hematopoietic neoplasia, with or without leukemia, in most rodent carcinogenicity studies. Standard histopathology is superior to periodic or terminal hematologic evaluation for identification of hematopoietic neoplasia. Although some affected animals have markedly elevated total WBC count and circulating neoplastic cells (e.g., blasts), many animals do not. Lymphocytic leukemia is the most commonly observed leukemia in laboratory rats and is occasionally observed as an incidental finding in subchronic studies (Frith et al. 1993). Large granular lymphocyte leukemia (also called mononuclear cell leukemia) is a relatively common finding in older Fischer 344 rats (Stromberg 1985). Affected rats often develop an immune-mediated hemolytic anemia with increased total bilirubin and liver enzyme activities. In peripheral blood, neoplastic cells appear as large, immature lymphocytes, frequently containing prominent azurophilic granules.
A mini-review on aplastic anemia, illustrated by a case report on bone marrow hot pockets mimicking sclerotic bone metastases
Published in Acta Clinica Belgica, 2022
Emilie Janssens, Jo Van Dorpe, Vanessa Van Hende, Ine Moors, Philip Vlummens, Ciel De Vriendt
No definitive etiology was found for the patient’s aplastic anemia. An inherited syndrome was unlikely, considering the patient’s age and negative family history. There was no previous exposure to radiation, toxins or cytotoxic drugs. She had no known immune disorders. At diagnosis there were no signs of hemolysis on peripheral blood or venous thrombosis. Fluorescein-labeled proaerolysin (FLAER) test showed insufficient arguments for paroxysmal nocturnal hemoglobinuria (PNH), detecting a PNH clone in only 8% of monocytes and 8% of granulocytes. Flow cytometry found no T-cell large granular lymphocyte leukemia (T-LGL). A routine viral serology was negative. Echography of the abdomen, RX mammography and breast echography were negative. A routine CT thorax was performed to exclude thymoma, underlying neoplasms and opportunistic infections. The latter revealed unexpected sclerotic bone conversions in the dorsal spine, most strikingly at D2, D11 and L2 (Figure 2). Additional whole body SPECT with 99mTc-HDP showed multiple bone lesions in the cervical, thoracic and lumbar spine. A CT guided biopsy of D12 showed no metastatic carcinoma or melanoma, but surprisingly revealed normal trilineage hematopoiesis with well-preserved erythropoiesis (Figure 3).
Evaluation of a 10color protocol as part of a 2tube screening panel for flow cytometric assessment of peripheral blood leukocytic subsets
Published in Scandinavian Journal of Clinical and Laboratory Investigation, 2019
Evdoxia Gounari, Vasiliki Tsavdaridou, Aliki Ioakeimidou, Anna-Bettina Haidich, Lemonia Skoura
According to current criteria [16,17] and immunophenotypic, morphological and available clinicolaboratory data, samples were classified into the following six diagnostic categories: (a) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)/high count CLL-like monoclonal B lymphocytosis (MBL), (b) low count CLL-like MBL, (c) non-CLL B LPD, (d) T cell large granular lymphocytic leukemia (T LGL), (e) other hematologic malignancies, and (f) no detectable neoplastic PB involvement. All samples with a CLL phenotype displayed a B population corresponding to a Matutes score equal to or greater than 4, with the exception of 1 sample with a score of 3, but fulfilling other immunophenotypic characteristics of CLL (CD43+, CD200+, and ROR-1+) [18,19]. Inversely, non-CLL B LPDs exhibited a CLL score equal to or less than 2 and a phenotype not compatible with CLL.
STAT1 and STAT3 mutations: important lessons for clinical immunologists
Published in Expert Review of Clinical Immunology, 2018
Peter Olbrich, Alexandra F. Freeman
To date, only one case of large granular lymphocytic leukemia (14 years old) and Hodgkin lymphoma (adult) has been reported [72,100]. Given the fact that somatic STAT3 GOF mutations are associated with malignancies (mostly large granular lymphocyte leukemia) this low number may be surprising. As most subjects in the STAT3 GOF cohorts are young children and incidences of oncohematologic diseases may potentially increase with time. Of note, two additional patients (age 38 and 31 years) were recently diagnosed with bilateral invasive SCC of the sinus [108] and breast cancer (Freeman AF, personal communication). Clinicians should therefore consider monitoring patients closely for the development of onco-hematologic diseases.