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The Abdomen
Published in Kenneth D Boffard, Manual of Definitive Surgical Trauma Care: Incorporating Definitive Anaesthetic Trauma Care, 2019
In severe liver injury, after successful surgical treatment including the removal of devascularized necrotic tissue and resectional debridement in selected cases, the liver is packed, and the injured area compressed with warm pads. After complete exploration of the abdomen and treatment of other injuries and sources of bleeding, the liver packs are removed and any slight oozing on the surface of the liver can be arrested by sealing with fibrin and collagen fleece as described above. Fibrin glue cannot, however, compensate for inadequate surgical technique.
Pilonidal Sinus
Published in Peter Sagar, Andrew G. Hill, Charles H. Knowles, Stefan Post, Willem A. Bemelman, Patricia L. Roberts, Susan Galandiuk, John R.T. Monson, Michael R.B. Keighley, Norman S. Williams, Keighley & Williams’ Surgery of the Anus, Rectum and Colon, 2019
The description of trephine removal of the midline pits and curettage of the cavity in 1,358 patients resulted in a 4% failure rate and a recurrence of 6.5% at a year, although this went up to 16% at ten years.46 This technique has been used along with fibrin glue.31
Facial Reanimation Surgery
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Demetrius Evriviades, Nicholas White
Immediate or early repair of nerve injuries should always be repaired if at all possible. Primary repair of the facial nerve should be performed using an operating miscroscope if possible. Epineural repair using 9/0 nylon is as successful as fascicular repair.10 Fibrin glue may also be used.11
Assessment of the Retinal Toxicity and Sealing Strength of Tissue Adhesives
Published in Current Eye Research, 2022
Anna Sharabura, John Chancellor, M. Zia Siddiqui, David Henry, Ahmed B. Sallam
Regarding the toxicity of adhesives on RPE cells, we found that fibrin and ReSure did not result in inhibition zones, as shown by the blue arrows in Figure 2. The arrows indicate the distance between the adhesive and the RPE cells. A large inhibition zone signified toxicity of the adhesive to the RPE cells through direct contact. These inhibition zones consist of affected cells around the rim of the drop and an empty space between the drop margins and cells showing a normal gross morphology. In contrast, the cyanoacrylates tested (dermabond, histoacryl, superglue) had significant inhibition zones measured at 24, 48, and 72 hours of incubation (p < .001, analysis of variance with Tukey HSD). Superglue formed the largest inhibition zone of 43.25 mm at 24 hours, followed by histoacryl (0.552 mm), and dermabond (0.242 mm). Quantifications of the inhibition zone at each time point are shown in Table 1. Tisseel fibrin glue is expected to be completely resorbed in 10–14 days after application.24 The cell culture with fibrin adhesive was cultured for 14 days to account for its resorption time, and there was no evidence of toxicity at this timepoint.
Pharmaceutical, biomedical and ophthalmic applications of biodegradable polymers (BDPs): literature and patent review
Published in Pharmaceutical Development and Technology, 2022
Barzan Osi, Mouhamad Khoder, Ali A. Al-Kinani, Raid G. Alany
Fibrin is a protein-based substance that is assembled in long fibrous chains. As a fibrinogen-derivative biopolymer produced by thrombi-medicated cleavage, fibrin plays an important role in many physiological processes such as hemostasis (Litvinov and Weisel 2016). The fibrin clot adheres to the native tissue, preventing the leakage of body fluid and enhancing cell proliferation (Kattula et al. 2017). Fibrin gel has been widely used to make drug carriers (Litvinov and Weisel 2016) and scaffolds for tissue engineering (Spicer and Mikos 2010; Rubalskii et al. 2019). Fibrin gel for tissue engineering applications has two functions: delivery vehicle and scaffolding matrix (Li et al. 2015; Zadeh et al. 2019). In addition, fibrin glue is used as a hemostatic agent and sealant in surgeries. Fibrin sealant is commercially available under different brand names such as Evarrest® Fibrin Sealant Patch (Ethicon US, LLC, Somerville, NJ, USA), VISTASEAL™ Fibrin Sealant (Human) Ethicon, Tisseel (Baxter Inc., Denmark), Crosseal (OMRIX Biopharmaceuticals Ltd. Israel), and Hemaseel (Heamacure Corp., Canada) (Duarte et al. 2012).
A review of techniques and challenges in performing sutureless intrascleral fixation of intraocular lens
Published in Expert Review of Ophthalmology, 2021
Neslihan Sevimli, Remzi Karadag, Özgür Çakıcı
Methods using the fibrin glue are mostly the same as the surgical steps in this technique. Nevertheless, in the last stage, instead of using fibrin glue, the scleral flap is closed with a suture [38,39]. Saleh et al [39]. examined 23 patients and 26 eyes. They divided the patients into two groups: one group that included eight eyes of eight patients. These patients underwent a sutureless intrascleral fixation IOL implantation procedure and the other group which included 18 eyes of 15 patients and they underwent posterior fixated iris-clamp lens surgery. While there was no intraoperative complication was observed in the posterior fixated iris-clamp lens group, one patient in the sutureless intrascleral fixation IOL group developed an intraoperative complication (haptic was broken and the posterior iris-clamp lens was implanted). It is commonly observed that postoperative complications were more likely to happen in the first 3 months. One patient in the sutureless intrascleral fixation IOL group had conjunctival erosion due to haptics. Postoperative cystoid macular edema was observed by other two patient. The most common complication in the posterior fixed iris-claw lens group was postoperative cystoid macular edema (three patients). Although the finding was not statistically significant, the more common in the posterior fixated iris-clamp lens group was surgically induced astigmatism. [39]