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Rheumatic Disease
Published in John S. Axford, Chris A. O'Callaghan, Medicine for Finals and Beyond, 2023
A normal ESR generally excludes active inflammation. A falsely low ESR can occur in sickle cell disease, anisocytosis, spherocytosis, polycythaemia and heart failure. A falsely raised ESR can result from prolonged blood storage or a measurement error. ESR and CRP levels may be inappropriately low in some patients (e.g. seronegative arthritis and LE respectively) and are not infallible markers of inflammation.
Diagnostic Reasoning and Clinical Problem Solving
Published in Cheston B. Cunha, Burke A. Cunha, Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine, 2020
The ESR may be elevated in many disorders. Diagnostic specificity of ESR elevations is increased when elevated. An acutely elevated ESR >100 mm/Hg limits Dx possibilities to S. pneumoniae or Legionnaire’s disease. Unelevated or moderately elevated ESRs may occur with any cause of CAP. Similarly, a very highly elevated CRP (>130) points to Legionnaire’s disease, but as an accurate phase reactant, it may be elevated in many acute pulmonary and non-pulmonary disorders.
Laboratory Diagnostic Tests in the Evaluation of Fever
Published in Benedict Isaac, Serge Kernbaum, Michael Burke, Unexplained Fever, 2019
Elevated ESR is found in infection, malignancy, and collagen-vascular disease, as well as pregnancy, myocardial infarction, and thyroid disease. Values exceeding 100 mm/h usually herald infection, 12 although cancer and rheumatic disease may also produce such elevations. Extreme elevations in patients with malignancy may signal the presence of metastases.
Effects of resistance training and nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production
Published in Archives of Physiology and Biochemistry, 2023
Soheila Jangjo-Borazjani, Maryam Dastgheib, Efat Kiyamarsi, Roghayeh Jamshidi, Saleh Rahmati-Ahmadabad, Masoumeh Helalizadeh, Roya Iraji, Stephen M Cornish, Shiva Mohammadi-Darestani, Zohreh Khojasteh, Mohammad Ali Azarbayjani
Results of this study showed that resistance training with Nigella sativa lead to a significant decrease in ESR. ESR is a test that indirectly measures the degree of inflammation present in the body. As noted above, resistance training reduces inflammation through various mechanisms. Also Nigella sativa can reduce inflammation. Some studies have shown that Nigella sativa inhibit inflammatory cytokines such as IL-1 and IL-6 (Shuid et al.2012). In another study, administration of aqueous extract of N. sativa inhibits production of 5-lipooxygenase (El-Dakhakhny et al.2002). Also the anti-inflammatory effects of N. sativa extract on LPS-induced inflammation in the mixed-glial cells and macrophages indicates a reduction in nitric oxide production by these cells (Salem 2005), which is probably due to the inhibition of inducible nitric oxide synthase (iNOS) by TQ (Mahmood et al.2003).
Prediction of inactive disease and relapse in oligoarticular juvenile idiopathic arthritis
Published in Modern Rheumatology, 2021
Müge Sezer, Fatma Aydın, Tuba Kurt, Nilüfer Tekgöz, Zahide Ekici Tekin, Cüneyt Karagöl, Nilgün Çakar, Banu Acar
Children who have extended arthritis are likely to have persistent disease that continues in the adulthood. In our study, the presence of ankle and foot joint arthritis, high JADAS 27 score and high ESR at the onset were found to be predictive factors of extended type oligoarticular JIA. Guillaume et al showed that the presence of 2–4 affected joints, upper limb involvement, and the ESR value at onset were found to be predictive factors of an extended oligoarticular JIA [21]. In another study, upper limb involvement and high ESR at onset were reported as a risk factor for extended oligoarticular JIA [12]. Nalbanti et al showed that high JADAS71 score at diagnosis was indicative of progression to extended oligoarticular JIA and the need for early introduction of biological treatment [22]. High ESR is often reported as a poor prognostic factor in studies. Although the relationship between extended oligoarticular JIA development and upper extremity involvement could not be shown in our study, high JADAS 27 score at the time of diagnosis was determined as a risk factor for extended oligoarticular JIA.
Preoperative Japanese Society for the Surgery of the Foot Lesser toe score and erythrocyte sedimentation rate influence wound healing following rheumatoid forefoot surgery
Published in Modern Rheumatology, 2021
Koji Ohta, Jun-ichi Fukushi, Satoshi Ikemura, Satoshi Kamura, Hisa-aki Miyahara, Yasuharu Nakashima
In the present study, preoperative ESR was significantly higher in the Delayed healing group (Tables 1 and 7). ESR is one of the most common laboratory measures to be used for the evaluation of RA disease activity [13]. However, it is unclear whether high ESR reflects local synovitis in the forefoot because the influence of small joint synovitis on ESR has been reported to be very small [14]. In the present study, we identified an inconsistent association between ESR and JSSF scores. Preoperative ESR was significantly associated with the total and function scores on the JSSF Hallux scale, but not with any scores on the JSSF Lesser toe scale. Unfortunately, we could not confirm the presence of local synovitis from the surgical records because relevant findings were not always documented. Although composite activity indices were not available in the present study, we expect that the high ESR reflects the general RA disease activity. In support of this contention, high disease activity has been reported to be associated with a higher risk of infection [15].