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Translating the Medical Record
Published in Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss, Understanding Medical Terms, 2020
Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss
Blood studies assess disorders of cell production (hematopoiesis), synthesis, and function. Examination of the blood and bone marrow are the primary means of determining blood disorders. Venipuncture is used to procure larger samples of blood for testing. Bone marrow specimens are obtained through needle biopsy or aspiration. A hemogram includes platelet count, white blood cell count (WBC), red blood cell count (RBC), hematocrit (Hct), and indices. A complete blood count (CBC) includes a hemogram plus differential count.
Branching out: Specialties and subspecialties in medical genetics
Published in Peter S. Harper, The Evolution of Medical Genetics, 2019
Blood disorders have figured strongly in the history of genetics in medicine for many years. Haemophilia, in particular, played a major role, though the first well documented families were from America (Otto 1803, Hay 1813). The fact that Queen Victoria was a carrier, with disastrous consequences for the royal families of Europe, gave it much publicity (see Rushton 2009); the disorder was largely responsible for the firm establishment of X-linked inheritance, while the work of Julia Bell and JBS Haldane established both the first human genetic linkage (Bell and Haldane 1937) and estimates for mutation rate (Haldane 1935).
Plants Species with Anticancer Activity
Published in Spyridon E. Kintzios, Maria G. Barberaki, Evangelia A. Flampouri, Plants That Fight Cancer, 2019
Evangelia Flampouri, Spyridon Kintzios, Maria Barberaki
The successful clinical introduction was substantially delayed, largely due to problems with insolubility and instability, particularly of the ring E lactone. Late diarrhea (generally occurring more than 24 hours after administration of Camptosar®) can be life threatening since it may be prolonged and may lead to dehydration, electrolyte imbalance, or sepsis. Late diarrhea should be treated promptly with loperamide. Patients with diarrhea should be carefully monitored and given fluid and electrolyte rement if they become dehydrated or antibiotic therapy if they develop ileus, fever, or severe neutropenia. The most common side effects with Hycamtin® (topotecan hydrochloride) are infections. Blood disorders are also common, where reduced levels of certain blood cells may cause anemia, reduced resistance to infections, and increased bruising or bleeding.
Combating malaria in Kenya through collaborative population health education: a systematic review and pilot case study
Published in Infectious Diseases, 2023
Hester Lacey, Nityanand Jain, Mai Sugimoto, Masako Shimato, Ieva Reine, Kevin Oria
The final risk group consists of children with blood disorders including anaemia and inherited blood disorders (Table 6). It has been shown that malarial infection in school children can impair cognitive performance and lead to poor educational achievements, mostly due to absenteeism and consequent grade repetition [56–58]. Malnutrition and parasitic helminthic infections are other important factors that need to be addressed through school educational programmes. These comorbidities are vital to be addressed since there seems positive association between malarial burden and anaemia [44]. Furthermore, malaria is a risk factor for anaemia. Hence, educational interventions targeting school children must also consider involving combating anaemia and educating about inherited blood disorders like glucose‐6‐phosphate dehydrogenase (G6PD) deficiency which was reported to be associated with a lower malarial prevalence among young males [45].
Cost-effectiveness of baloxavir marboxil compared with laninamivir for the treatment of influenza in patients at high risk for complications in Japan
Published in Current Medical Research and Opinion, 2021
Mariia Dronova, Hidetoshi Ikeoka, Naoya Itsumura, Nobuo Hirotsu, Amir Ansaripour, Samuel Aballéa, Yoshie Onishi, Mark Hill, Ataru Igarashi
The following list of HRC was considered in line with the Centers for Disease Control and Prevention’s definition and phase III clinical trial of baloxavir3,8:Asthma or chronic lung disease.Endocrine disorders.Compromised immune system.Neurological and neurodevelopmental disorders.Heart disease (excluding hypertension).Blood disorders.Metabolic disorders.Morbid obesity.Women within 2 weeks postpartum – for patients aged <65 years only.Residents of long-term care facilities – for patients aged ≥65 years only.
Trends, predictors, and outcomes of major bleeding after transcatheter aortic valve implantation, from national inpatient sample (2011–2018)
Published in Expert Review of Cardiovascular Therapy, 2021
Salman Zahid, Waqas Ullah, Muhammad Usman Khan, Sakina Abbas, Mian Tanveer Ud Din, Muhammad Faisal Uddin, Arslan Inayat, Aamer Ubaid, Fnu Salman, Samarthkumar Thakkar, Amr Salama, Muhammad Zia Khan
The higher bleeding complications with baseline hematological problems related to platelets and coagulation factors were identified in our study. These findings are reinforced by a well described association of major bleeding events with blood disorders in previous literature [9]. In addition to this, patients with ESRD have a propensity to bleed due to the inherent platelet dysfunction and thus are associated with high mortality [10,[11]. Similarly, Liver disease patients have increased tendency to bleed due to associated coagulopathy [12]. These findings were reinforced in a previous meta-analysis consisting of 1652 patients where chronic liver disease patients had higher incidence of mortality, bleeding complications and need for blood transfusions [13]. This association is further exacerbated by anti-platelet and anticoagulant drug use [14,[15].