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Anti-Aging and Regenerative Medicine
Published in Aruna Bakhru, Nutrition and Integrative Medicine, 2018
Franceschi et al. coined the term “inflammaging,” which denotes the upregulation of the inflammatory response with aging and the ensuing low-grade, chronic, systemic proinflammatory state that is associated with most age-associated diseases (Franceschi et al. 2000).
Immunology of Aging and Cancer Development
Published in Shamim I. Ahmad, Aging: Exploring a Complex Phenomenon, 2017
T. Fulop, J. M. Witkowski, G. Dupuis, A. Le Page, A. Larbi, G. Pawelec
As mentioned above, it is the dysregulation of an adaptive inflammatory response occurring with aging under various stimuli that may induce most of the apparently different diseases of the elderly [6,104]. Probably during the development of these diseases, the equilibrium between pro-inflammatory and anti-inflammatory signals is disrupted and the above-mentioned “hyperinflammation” will pave the way for the pathological consequences. Excessive inflammation during the inflammaging process increases susceptibility to various pathologies; diseases as diverse as diabetes mellitus, cardiovascular diseases, Alzheimer's disease, cancer, and sarcopenia may all be related to the inflammatory process observed in elderly subjects. Of course, the relationship between inflammaging and these diseases is complex and occurs through many different intertwined pathways [102] largely influencing each other. In the remainder of this chapter, we will specifically examine the relationship between inflammaging and immunosenescence, and the development of cancer.
Frailty, Nutrition, and the Elderly
Published in David Heber, Zhaoping Li, Primary Care Nutrition, 2017
The term inflammaging was developed to describe an upregulation of the inflammatory response that occurs with age, resulting in a low-grade chronic systemic pro-inflammatory state that plays a role in progressing aging (Franceschi et al. 2000; Vasto et al. 2007). In this sense, aging resembles age-related chronic diseases, and while aging cannot be reversed (you cannot stop time), the ravages of aging can be reduced through healthy diet and lifestyle. Inflammaging is characterized by raised levels of inflammatory cytokines, including interleukin 1 (IL-1), IL-6, and tumor necrosis factor α (TNF-α). These cytokines have been shown to rise with age (De Martinis et al. 2006) and be involved in the pathogenesis of most age-related chronic diseases (De Martinis et al. 2006). C-reactive protein (CRP), also known as high-sensitivity CRP (hsCRP), is an acute-phase protein produced by the liver in response to inflammation. It is also a useful marker of inflammation associated with aging and chronic diseases when the highly sensitive assay for it is used. hsCRP in the upper quartile of the normal range is used clinically as a predictor of the risk for cardiovascular and other age-related chronic diseases (Buckley et al. 2009; Ansar and Ghosh 2013). In practice, it is elevated well above the normal range by mild upper respiratory viral infections and other common infections, limiting its usefulness in screening and follow-up.
Synbiotic supplementation, systemic inflammation, and symptoms of brain disorders in elders: A secondary study from a randomized clinical trial
Published in Nutritional Neuroscience, 2020
Eliana Regina Louzada, Sandra Maria Lima Ribeiro
Aging is associated with a status of systemic inflammation, which some authors name as inflammaging.1 Although the precise origin of this inflammatory status is quite unknown,2 different hypotheses have been proposed, such as the immunosenescence, the body fat and the intestine. About intestine, during aging, the balance between bacterial species in this organ changes, leading to consequences such as harming of the proteins in the enterocytes tight junctions, allowing the passage of bacteria or bacterial fragments towards the systemic circulation. These fragments find specific receptors in a number of tissues, attracting inflammatory cells.3 In addition, accumulation of body fat and centralization (abdominal accumulation) is typical during aging, and adipocytes are capable of accumulating macrophages and T cells by infiltration.4,5 All these modifications due to aging increase the chronic inflammatory conditions.6–8
Inflammaging
Published in Immunological Investigations, 2018
Inflammaging was coined by Franceschi et al. in 2000, representing a newer dimension to aging studies and decrees that the aging process has a chronic progressive proinflammatory phenotype (Franceschi et al., 2000). Inflammaging plays an increasingly important role in the rate of aging and age-related diseases. Research in this area has attracted attention of academics in diverse fields of study that have made significant impacts in the past decade. In this thematic issue, we present manuscripts representing varied fields of study that capture aspects of inflammaging. We also discuss the relationship of inflammaging with various diseases described below that suggest potential novel interventions to delay or prevent inflammaging-related diseases.
Design and optimization strategies for the development of new drugs that treat chronic kidney disease
Published in Expert Opinion on Drug Discovery, 2020
Adrián M. Ramos, Beatriz Fernández-Fernández, María Vanessa Pérez-Gómez, Sol María Carriazo Julio, María Dolores Sanchez-Niño, Ana Sanz, Marta Ruiz-Ortega, Alberto Ortiz
Several novel therapeutic approaches have demonstrated benefit in preclinical studies or are at the early stages of clinical development (Figure 1). Inflammaging refers to the association between inflammation and accelerated aging [66]. Inflammaging may be a consequence of CKD, driving accelerated aging and cardiovascular mortality, but also a contributor to kidney injury and CKD progression. Thus, it represents an interesting therapeutic target. Among the potential mechanisms of inflammaging, we find cell senescence and, in the context of CKD, the loss of Klotho expression.