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Diseases of the Hepatobiliary Tree and Pancreas Associated with Fever
Published in Benedict Isaac, Serge Kernbaum, Michael Burke, Unexplained Fever, 2019
Clonorchiasis — This is caused by the Oriental liver fluke, Clonorchis sinensis, is endemic in the Far East and may present with a febrile course. The most common complication is recurrent pyogenic cholangitis or Oriental cholangiohepatitis, which is characterized by repeated bouts of abdominal pain and fever, associated with jaundice, hepatomegaly, and frequently, eosinophilia. Intravenous cholangiography may demonstrate dilated intrahepatic bile ducts with partial filling defects which represent flukes. Tiny opercular ova observed in the feces will confirm the diagnosis. The complications, pancreatitis and cholangiocarcinoma, may sometimes evolve with a febrile course.
Bile duct stones
Published in David Westaby, Martin Lombard, Therapeutic Gastrointestinal Endoscopy A problem-oriented approach, 2019
Stones within the common hepatic and intrahepatic ducts may complicate any condition impeding bile drainage. In Asia, they are a serious consequence of the infective condition cholangiohepatitis or recurrent pyogenic cholangitis.
Liver, biliary system and pancreas
Published in Michael Gaunt, Tjun Tang, Stewart Walsh, General Surgery Outpatient Decisions, 2018
Satyajit Bhattacharya, Adrian O’Sullivan
Recurrent pyogenic cholangitis is prevalent in Southeast Asia. It may occur in immuno-compromised people. There are recurrent bouts of bacterial cholangitis leading to formation of pigment stones and strictures. It affects intra- and extrahepatic ducts with a predilection for the left lobe of the liver.
Benefit of measuring vedolizumab concentrations in inflammatory bowel disease patients in a real-world setting
Published in Scandinavian Journal of Gastroenterology, 2021
Sara Kolehmainen, Tero Ylisaukko-oja, Jari Jokelainen, Mirkka Koivusalo, T. Sakari Jokiranta, Taina Sipponen
VDZ treatment was discontinued in 37 (41.1%) patients and occurred mainly (n = 31, 83.8%) due to inadequate response to therapy (Table 6). No significant difference in VDZ TC between patients who continued the therapy and the ones who discontinued was observed (p > .05). Adverse events (arthralgia, infusion reaction, infection) were the cause of VDZ discontinuation in 8.1% of patients. Other causes for discontinuation were the patient’s will, remission, and recurrent pyogenic cholangitis. At six months after treatment initiation, 88.0% of UC and 91.0% of CD patients remained on treatment. Increased dose frequency had no effect on treatment persistence compared to patients with no dose intensification (p > .05). Also, no significant differences between CD and UC on drug persistence were detected (p > .05).
A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis
Published in Current Medical Research and Opinion, 2019
Chien-Hua Chen, Cheng-Li Lin, Chung Y. Hsu, Chia-Hung Kao
Cholelithiasis includes intrahepatic stones (IHSs), common bile duct (CBD) stones, and gallstones. Cholelithiasis is a major health problem because it can lead to cholecystitis, cholangitis, pancreatitis, and even cholangiocarcinoma. The development of IHSs is common in Eastern Asia, and this disease is often referred to as recurrent pyogenic cholangitis or Oriental cholangiohepatitis1. However, the formation of gallstones is more common in Western countries2. CBD stones may originate from the CBD itself, due to anatomical stricture or dilatation; these stones may also originate from the gallbladder or the intrahepatic ducts, due to stone passage.