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Global Medicinal Plants and Phyto-Derived Compounds in Wound Healing
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Samantha R. Loggenberg, Namrita Lall
However, MASD requires more than moisture damage in order to occur. Severe skin ulceration may be attributable to multiple factors, such as chemical irritants within the moisture source, changes in pH, mechanical factors such as friction and pathogenic wound-associated bacteria (Gray and Weir, 2007; Gray et al., 2011). Ulceration may result from chronic wound hypoxia and impaired micronutrient delivery caused by MASD, thus decreasing the process of angiogenesis which ultimately delays the wound healing process. Severe ulceration in wounds may be prevented with the use of wound dressings to limit moisture exposure. However, chronic skin ulcers may be susceptible to excessive inflammation and prolonged wound healing, which may ultimately hinder patient health and mobility (Gray and Weir, 2007).
An Insight into Advanced Nanoparticles as Multifunctional Biomimetic Systems in Tissue Engineering
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Kusha Sharma, Abhay Tharmatt, Pooja A Chawla, Kamal Shah, Viney Chawla, Bharti Sapra, Neena Bedi
The first tissue-engineered skin products that were developed for the treatment of burns include Integra (Integra Lifesciences Corporation, USA), Epicel (Genzyme Biosurgery, USA), and TransCyte (Smith and Nephew, UK). Several products are available for chronic skin ulcer management, such as Apligraf (Organogenesis, USA), Dermagraft (Smith and Nephew, UK and Advanced Tissue Sciences, USA), EpiDex (Euroderm, Germany), Epibase (Laboratories Genévrier, France), and BioSeed-S (BioTissue Technologies, Germany). The tissue-engineered products are also commercially available for cosmetic surgery applications such as BioSeed-M and MelanoSeed (BioTissue Technologies AG, Germany) (Law et al., 2017). Several stem cell engineered products are currently in development and are being tested in clinical and preclinical trials (Wang et al., 2017). Nanoparticles (NP) are solid colloidal particles, and their size range is 10–200 nm. Their small size provides a high surface to volume ratio, one of their most attractive intrinsic properties (Acharya and Sahoo, 2011). Due to their size and surface properties, NPs can be exploited as theranostic agents, drug delivery systems, genetic material, and growth factors. NPs used in biomedicine must be biocompatible, and the stability of nanocarriers in biological media is crucial when formulating nanomedicines (Figure 1.1).
Swelling of the Phalanges (Bony Cysts)
Published in K. Gupta, P. Carmichael, A. Zumla, 100 Short Cases for the MRCP, 2020
K. Gupta, P. Carmichael, A. Zumla
Most patients with joint involvement often have co-existing manifestations of erythema nodosum and hilar lymphadenopathy. Arthritis usually responds well to non-steroidal antiinflammatory agents without any residual deformities. Bone pain and swelling are common features of bone infarction that may result from veno-occlusive crisis in sickle cell disease. Bone infarction may also affect other joints and organs, especially the kidneys. Chronic non-healing skin ulcers are commonly present in these patients. Haemoglobin electrophoresis is helpful in confirming the diagnosis of sickle cell anaemia.
Comparison of the efficacy of focused ultrasound at different focal depths in treating vulvar lichen sclerosus
Published in International Journal of Hyperthermia, 2023
Ru Jia, Can Wu, Xiaoxu Tang, Miaomiao He, Xinglin Liu, Chang Su, Chengzhi Li
Immediately after treatment, the skin in the treated region showed slight redness and swelling but no pain in both groups. The congestion and edema of the vulva peaked 24 h after treatment and completely subsided 5–7 days after symptomatic treatment. The skin gradually returned to normal. Two patients in the experimental group developed vulvar skin ulcers 7 days after treatment (Table 2). In the control group, one patient developed blisters in the upper part of the vulva on both sides and lesions in the small and large labia after 12 h of treatment, exhibited ecchymosis under the skin after 48 h and developed ulcers after 10 days. In another patient, the lesion was in the lower part of the bilateral interlabial sulcus and the perineum and blisters appeared after treatment and subsequently developed into ulcers. Figures 1 and 2 showed the side effects after FU treatment at 4.0 and 2.5 mm focal depths. Both groups were cured after symptomatic anti-inflammatory treatment without scarring. No urinary tract injury, infection or other serious complications occurred during or after operation in the two groups.
Racial disparities in the management of skin ulcers: an analysis of the National Ambulatory Medical Care Survey, 2012–2018
Published in Journal of Dermatological Treatment, 2022
Isabelle H. Moseley, Sara D. Ragi, Adriana Lombardi
We also found that White patients were more likely than Black patients to be scheduled for a follow-up appointment and that White patients are more likely to receive cryotherapy treatment than Black patients. This discrepancy may be explained by the fact that White patients were more likely to be treated by a physician, while Black patients were more likely to be treated by a nurse practitioner. Nurse practitioners may feel less comfortable performing this procedure as compared to physicians and may have less expertise in determining whether cryotherapy is needed to treat a skin ulcer. However, additional studies are needed to assess racial differences in skin ulcer treatment and the effect on patients’ health. The findings of this study may inform medical education on racial disparities in dermatologic care and aid dermatologists in addressing these disparities. Further research is necessary to provide support for our findings and provide more information on the mechanisms underlying such differences in skin ulcer management.
Platelet-rich fibrin and concentrated growth factors as novel platelet concentrates for chronic hard-to-heal skin ulcers: a systematic review and Meta-analysis of randomized controlled trials
Published in Journal of Dermatological Treatment, 2022
Jianguo Chen, Yingying Wan, Yan Lin, Haiyue Jiang
The characteristics of eight included studies (27–34) were summarized in Table 1, and the characteristics of chronic skin ulcers were described in Table 2. The studies were published between 2016 and 2020. A total of 578 patients were included with a mean follow-up duration of 8.375 weeks. Complete healing of chronic ulcers was defined as complete epithelialization. Planimetry techniques were used in included studies to measure ulcers area. Five studies (27–31) reported PRF dressings for chronic skin ulcers versus standard wound care without use of PRF. Among them, three studies (28,30,31) were performed only in patients with venous ulcers. One multicenter trial (27) was conducted in patients with diabetic ulcers. Another study (29) was carried out for chronic skin ulcers of various etiologies, involving venous ulcers, traumatic ulcers, infectious ulcers and bed sores. Furthermore, one study (32) reported CGFs dressings for chronic skin ulcers of various etiologies, and another study (33) reported CGFs dressings for venous ulcers. Only one studies (34) compared PRF to PRP for chronic skin ulcers of various etiologies. The risk of bias assessment of included studies was shown in Figure 2. All included studies performed randomization. Four studies did not carry out blinding of participants.