China
Africa
Explore chapters and articles related to this topic
Polymorphous Light Eruption
Published in Henry W. Lim, Nicholas A. Soter, Clinical Photomedicine, 2018
Historical sources let us assume that Robert Willan, at the end of the 18th century, reported for the first time in the medical literature a recurrent sunlight-induced rash for which the term “eczema solare” was coined (1). Nearly a century later, Jonathan Hutchinson (2) used the term “summer prurigo” to define an eruption of red, itchy papules mainly affecting the arms and the face that started after puberty and continued for many years during summer with remissions during winter. It is very likely that he described some forms of polymorphous light eruption and perhaps some other idiopathic photodermatoses such as hydroa aestivale or photosensitive eczema. In 1900, Rasch (3), and later in 1918, Haxthausen (4), grouped eczematous and papular photodermatoses and introduced the term chronic polymorphous light eruption. During subsequent decades a variety of photosensitivity dermatoses of unknown pathogenesis, such as solar urticaria, photoallergic dermatitis, hydroa vacciniforme, erythropoietic protoporphyria, and lupus erythematosus were probably lumped together (5). These diseases are now clearly defined as distinct clinical entities. The term polymorphous light eruption is now restricted to a better delineated group of sun-induced skin rashes. However, it is likely that this term still encompasses several photosensitivity conditions with different pathogenetic mechanisms. The different action spectra and the inter-individual polymorphism of the lesions may support this concept (5–7).
Principles of Clinical Diagnosis
Published in Susan Bayliss Mallory, Alanna Bree, Peggy Chern, Illustrated Manual of Pediatric Dermatology, 2005
Susan Bayliss Mallory, Alanna Bree, Peggy Chern
Van Praag MCG, Boom BW, Vermeer BJ. Diagnosis and treatment of polymorphous light eruption. Int J Dermatol 1994; 33: 233–8 Solar urticaria
Himalayan poisonous plants for traditional healings and protection from viral attack: a comprehensive review
Published in Toxin Reviews, 2022
Shriya Pathania, Diksha Pathania, Priyanka Chauhan, Mamta Sharma
Phyto-photodermatitis (PPD) also known as dermatitis pratensis that can be identified by cutaneous phototoxic inflammatory eruption resulting from contact with botanical substances which are light sensitizing (Wink 2010). The skin lesions are similar to burns. There is a delay between skin contact and the first signs of irritation. Phyto-photodermatitis should not be confused with contact allergy or with photoallergic reactions such as polymorphous light eruption, persistent light reaction, or solar urticaria. The treatment consists of thorough cleansing of the skin and application of a steroid cream. Celery, parsnips, figs, and parsley foods should be avoided by people with photodermatitis, e.g. in SLE because of containing large amounts of psoralens.
Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models
Published in Drug Delivery, 2022
Quan Rao, Guang-chao Ma, Hao Wu, Meng Li, Wei Xu, Guo-jun Wang, Dong Wang, Cong-en Zhang, Zhi-jie Ma, Zhong-tao Zhang
Our findings provide a strategy for not only treating UC but also reducing TP toxicity. DCTP also show promise for the treatment of other autoimmune diseases such as rheumatoid arthritis and a variety of skin diseases, including psoriasis, allergic contact dermatitis, polymorphous light eruption, erythema multiforme, atopic dermatitis, and pemphigus, that have been effectively treated with TP (Han et al., 2012; Yuan et al., 2019; Zhao et al., 2019a). Moreover, Zhang et al. (2013) found that infusion of DCTP into recipients before transplantation prolonged rat kidney allograft survival. Overall, TP combined with DCs may have excellent application prospects in the clinic.
A novel case of eruptive vellus hair cysts arising during radiation therapy and a brief review of the literature
Published in Acta Oncologica, 2023
Ahava Muskat, Neda Shokrian, Yana Kost, Pooja Srivastava, Bijal Amin, Beth N. McLellan
We present the first case of a persistent EVHC eruption triggered by RT. This eruption was generalized, as it was not limited to the irradiated field. The phenomenon of a new skin eruption due to RT, extending beyond or not involving the irradiated field at all, has been well described in other cutaneous conditions, such as post-irradiation morphea [5,6], eosinophilic polymorphic and pruritic eruption associated with radiotherapy [7], generalized bullous pemphigoid [8], radiotherapy-induced pemphigus [9], erythema multiforme or erythema-multiforme-like rash [10], and RT-induced polymorphous light eruption [10]. No particular time frame or radiation dose has been implicated in these eruptions. Like the present case, breast cancer was the most common cancer associated with these generalized eruptions, portending a potential common hormonal pathogenic link between breast cancer and resulting radiation-induced generalized cutaneous reactions, as suggested by some authors [7]. Furthermore, some theorize that EVHC arise due to a defect in keratinization or vellus hair follicle formation, both of which can be heavily influenced by sex-hormone alterations [11–14]. Another hypothesis for radiation-induced generalized cutaneous reactions is that localized RT may induce a systemic release of autoantibodies, antigens, immune complexes, or cytokines, which could trigger widespread cutaneous reactions [5,15]. As the pathogenesis of EVHC itself is poorly understood, it is difficult to clearly explicate how RT might induce this eruption, but the current literature supports and provides significant evidence for generalized radiation-induced dermatologic conditions with varying known etiologies. Additionally, the time frame of this patient’s eruption (during RT and persisting afterward), along with a lack of comorbidities associated with EVHC (such as steatocystoma), or a contributory family history, supports our hypothesis.