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Principles of Dermoscopy and Dermoscopic Equipment
Published in Ashfaq A Marghoob, Ralph Braun, Natalia Jaimes, Atlas of Dermoscopy, 2023
Neda Shahriari, Jane M. Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope
Dermatoscopy, also known as dermoscopy, uses a handheld microscope called a dermatoscope that is equipped with a magnification lens and a light source. Although unaided (naked-eye) visual inspection of the skin affords the clinician an appreciation of the gross morphologic features of lesions, such as their size, symmetry, shape, colors, contour, and surface topography, dermoscopy is unique in allowing the clinician to see structures not visible to the naked eye. This device allows the observer to survey the subsurface primary morphology of cutaneous lesions through an examination of the stratum corneum to the level of the superficial dermis. For this reason, in the hands of experienced users, dermoscopy can improve the clinician's diagnostic accuracy [3,11] and confidence level [5] for pigmented [7,17,19] and nonpigmented skin lesions.
Diagnosing Skin Disease
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
With the advent of portable handheld dermatoscopes, the practice of dermatoscopy has become ubiquitous in dermatology. The technique involves rendering the cornified layer translucent either by using polarized light or immersion contact with the skin, thereby exposing subsurface structures that can be better visualized (Figure 2.11). The most widely utilized dermatoscope consists of polarized light capable of 10× magnification. Special attachments and adaptors for cameras and smartphones allow easy capture and sharing of dermatoscopic images.
Introduction to Dermatoscopy
Published in Aimilios Lallas, Zoe Apalla, Elizabeth Lazaridou, Dimitrios Ioannides, Theodosia Gkentsidi, Christina Fotiadou, Theocharis-Nektarios Kirtsios, Eirini Kyrmanidou, Konstantinos Lallas, Chryssoula Papageorgiou, Dermatoscopy A–Z, 2019
Aimilios Lallas, Zoe Apalla, Elizabeth Lazaridou, Dimitrios Ioannides, Theodosia Gkentsidi, Christina Fotiadou, Theocharis-Nektarios Kirtsios, Eirini Kyrmanidou, Konstantinos Lallas, Chryssoula Papageorgiou
The dermatoscope is a handheld device with 10-fold magnifying optics, combined with a transilluminating light source. The expanded use of dermatoscopy among clinicians is based on the following important strengths: it is a fast and effective method applied with a small and inexpensive device. Therefore, the dermatoscope should be considered not as an imaging device but as a clinical tool that can be routinely used on all skin lesions by any physician dealing with skin disorders, acquiring a role similar to the stethoscope of physicians.
Oleuropein as a novel topical antipsoriatic nutraceutical: formulation in microemulsion nanocarrier and exploratory clinical appraisal
Published in Expert Opinion on Drug Delivery, 2021
Riham I. El-Gogary, Maha H. Ragai, Noha Moftah, Maha Nasr
Dermoscopic evaluation was further conducted on the lesions of both sides using Dermlite dermoscope. Photographs were compared before and after treatment for 8 weeks, in order to assess the typical dermoscopic criteria characteristic for plaque psoriasis; namely, the white scales and regularly distributed dotted vessels on a light red background [67]. In addition, skin biopsy specimens were obtained from lesional areas using 3-mm punch probes before and after treatment, then stained using (H&E) staining, followed by examination using light microscope (A3025-5 Olympus, Japan). Morphometric measurement of epidermal thickness of the skin was also performed for both treated sides before and after treatment using a software (analysis®Five, Olympus Soft imaging solutions, Germany) [68].
An exploratory pilot analysis of the optimal pellet number in 100 mg of itraconazole capsule to maximize the surface area to satisfy the Noyes–Whitney equation
Published in Journal of Dermatological Treatment, 2021
Kabir Sardana, Ananta Khurana, Sanjeet Panesar, Ajeet Singh
Twenty-nine commercial preparations of ITR, including the innovator brand, were assessed in the month of January 2019. The capsule shell was opened and the pellets counted. Thereafter, the samples were subjected to dermoscopy using Dinolite AM 4113 ZT-R4 digital video dermoscope, with inbuilt measurement tools, using polarized light. Digital microscopes blend traditional microscope technology with advanced cameras and software to enhance ease of viewing and to make saving or sharing images easy in all settings. These are now being increasingly used as magnification tools both in health care and industry owing to the ease of use in a clinic/field setting, no requirement for eyepieces—with images being directly displayed on a laptop/mobile screen and ability to view magnified images in real motion. Further, magnification of large three dimensional objects like the pellets here is not possible with the conventional microscopes and hence the estimation was done using a dermoscope. Dermoscope is a tool dermatologists are familiar with and hence we preferred to use this over Vernier’s calipers to ensure easy reproducibility of our methodology.
The role of nailfold videocapillaroscopy in patients with systemic sclerosis
Published in Immunological Medicine, 2018
Satoshi Kubo, Vanessa Smith, Maurizio Cutolo, Yoshiya Tanaka
NVC represents the best and safest method to detect and analyze morphological microvascular abnormalities. Nailfold is the skin that overlaps the edge of a fingernail. The dermis is thin at this site anatomically, and the capillary can be seen directly. Capillary abnormalities of the nailfold are often seen in patients with SSc. Since dermatoscopy (30 magnifications) suffices for distinguishing between normal and abnormal nailfold capillaries, dermatoscopy has been used to detect the nailfold capillaries in Japan. Although dermatoscopy is convenient to carry out, inexpensive and simple, it is not suitable for detailed analysis of the capillary. On the other hand, NVC can allow analyzing of the shape of a capillary in detail at a high magnification of 200 or more and is superior to dermatoscopy in that it can accurately measure the length, thickness and twist, although training for evaluation is required. From this point of view, clinical research by NVC has been recognized as useful for understanding the pathogenesis. It is desirable that physicians caring for SSc patients use videocapillaroscopy to take an accurate measurement of the fineness and the number of capillaries.