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Benign Nonmelanocytic Skin Tumors
Published in Aimilios Lallas, Zoe Apalla, Elizabeth Lazaridou, Dimitrios Ioannides, Theodosia Gkentsidi, Christina Fotiadou, Theocharis-Nektarios Kirtsios, Eirini Kyrmanidou, Konstantinos Lallas, Chryssoula Papageorgiou, Dermatoscopy A–Z, 2019
Aimilios Lallas, Zoe Apalla, Elizabeth Lazaridou, Dimitrios Ioannides, Theodosia Gkentsidi, Christina Fotiadou, Theocharis-Nektarios Kirtsios, Eirini Kyrmanidou, Konstantinos Lallas, Chryssoula Papageorgiou
Clear cell acanthoma (CCA) is a benign tumor with a not fully elucidated pathogenesis. Although it was considered a benign epidermal tumor, recent evidence rather suggests that it is a reactive inflammatory dermatosis. Clinically, it appears as a red-purple nodule (Figure 4.40) more often on the lower extremities. Differential diagnosis includes benign and malignant skin tumors as well as inflammatory skin diseases. Dermatoscopically, it is characterized by the presence of dotted and sometimes glomerular vessels arranged linearly like strings of pearls. This unique dermoscopic pattern is almost pathognomonic and allows a straightforward diagnosis (Figure 4.41).
Tumors of the Epidermis
Published in Omar P. Sangueza, Sara Moradi Tuchayi, Parisa Mansoori, Saleha A. Aldawsari, Amir Al-Dabagh, Amany A. Fathaddin, Steven R. Feldman, Dermatopathology Primer of Cutaneous Tumors, 2015
Clear cell acanthoma Glycogenated pale segment of epidermis is sharply demarcated from the surrounding skinNeutrophils are noted throughout the lesion and in the overlying crustNeutrophils are noted throughout the lesion and in the overlying crust
Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation
Published in Journal of Dermatological Treatment, 2022
Claire Drumm, Kok Ngan, Juliano Crema, Nitin Khirwadkar, Charlotte Defty, Karen Eustace
Clear cell acanthoma (CCA) is a rare, benign epidermal lesion of clear glycogen-containing keratinocytes. The exact etiology is unknown. It remains unclear whether CCA represents a benign tumor or an inflammatory dermatosis (1). Lesions most commonly occur on the lower extremities of middle-age patients with no gender predilection. CCA typically present as pruritic, slow-growing, well-demarcated, red to brown dome-shaped papules or nodules, often with a peripheral collarette of scale (2). Although CCA usually appear as solitary lesions, cases of multiple CCAs have also been described in the literature. The rare eruptive CCA variant describes cases with more than 30 lesions (1).