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Nonmelanocytic Lesions
Published in Ashfaq A Marghoob, Ralph Braun, Natalia Jaimes, Atlas of Dermoscopy, 2023
Sarah N. Hocker, Harold S. Rabinovitz, Margaret C. Oliviero, Ashfaq A. Marghoob
Seborrheic keratoses are benign epithelial lesions that can appear on any part of the body except for the mucous membranes, palms, and soles. The lesions are quite prevalent in people older than 30 years. The etiology of seborrheic keratoses remains unclear. Ultraviolet light exposure may be responsible for the development of some seborrheic keratoses, because they appear to evolve from solar lentigines (Figure 6e.3); however, many develop in areas of the skin naturally protected from ultraviolet light exposure, such as the inframammary (intertriginous) areas.
Adult Ocular and Orbital (Ocular Adnexa) Tumors
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
P.N. Plowman, Rachel Lewis, J.L. Hungerford
Epithelial tumors mainly comprise benign papillomas of the eyelid margin, which are extremely common and of viral origin. They are easily treated by shaving and light cautery to the base, but they tend to recur. Recurrent tumors may be managed by wedge excision. Seborrheic keratosis is particularly common in the elderly and may be treated by curettage. Cryotherapy may be performed for tumors of this type in pale-skinned individuals, but it should be avoided in those with darker coloring because it is likely to be followed by noticeable depigmentation.
Melanomas
Published in E. George Elias, CRC Handbook of Surgical Oncology, 2020
Other benign lesions that are not related to melanoma, but may have some pigmentation due to various reasons include the thrombosed and sclerosing hemangiomas, pyogenic granuloma with hemorrhage, epidermoid cyst with hemorrhage, and simple wart. Glomus tumors may be single or multiple. The single ones favor the extremities and the nail beds. They are usually tender. The multiple variety are usually asymptomatic, blue, soft, and may be dermal or s.c. Their nature is not known, but these are formed of neurofibrous bundles in the skin areas overlying the bone such as elbows, knees, tibial, and ulnar shafts. These are completely unrelated to melanomas. Seborrheic keratosis is usually a verrucous lesion that has a stuck-on appearance. It has well-demarcated, raised edges and is frequently seen in the middle-aged and elderly. This lesion is formed of epidermal cells and not melanocytes.
Picosecond alexandrite laser is superior to Q-switched Nd:YAG laser in treatment of minocycline-induced hyperpigmentation: A case study and review of the literature
Published in Journal of Cosmetic and Laser Therapy, 2018
Both Q-switched and picosecond lasers have demonstrated effectiveness in treating minocycline hyperpigmentation. In this case, we compare the efficacy of Q-switched Nd:YAG to picosecond laser in a patient with type III minocycline pigmentation, following a 5-year period of low-dose minocycline (50 mg daily) with a total cumulative dose in excess of 100 g. Over 4 months, we observed a partial response to Q-switched laser over five sessions, and a near-complete resolution in the patients rash over four sessions of picosecond laser, over a 4-month period. Although Q-switched lasers have previously been demonstrated as successfully reducing minocycline hyperpigmentation, our results demonstrated an increased efficacy with picosecond laser, requiring fewer sessions to achieve clearance in the patient’s pigmentation. The treatment was well tolerated by the patient and did not cause any hypopigmentation or scarring. The authors also noted an improvement in the patient’s seborrheic keratoses following her treatment.
Efficacy and safety of topical treatments for seborrheic keratoses: a systematic review
Published in Journal of Dermatological Treatment, 2023
Nicole Natarelli, Amanda Krenitsky, Kerry Hennessy, Sarah Moore, James Grichnik
Seborrheic keratoses (SK) are benign epithelial neoplasms with a prevalence of 69% in patients aged 50 and older. They commonly appear on the face, chest, shoulders, or back and present as light tan, brown, or black papules or plaques with a waxy, ‘stuck on’, appearance (1). Treatment is not necessary, although patients often request removal secondary to irritation or pruritus, or for cosmetic reasons. A survey of 594 board-certified dermatologists reported an average of 155 SK diagnoses monthly, with 43% of patients requesting removal (2).
Extranodal NK/T-cell lymphoma, nasal type, with extranasal presentation – a case report and a review of the literature
Published in Acta Oncologica, 2020
Momena Akbar, Erik Clasen-Linde, Lena Specht
The patient was referred to an ophthalmologist who took total three biopsies within a period of seven months. The first biopsy showed seborrheic keratosis. The condition worsened and a new biopsy showed granulomatous inflammation. The tumor continued to grow, and the third biopsy gave the final diagnosis of extranodal NK/T-cell lymphoma of nasal type.