China
Africa
Explore chapters and articles related to this topic
Neuropathology Of Neuro-Ophthalmic Disorders
Published in Vivek Lal, A Clinical Approach to Neuro-Ophthalmic Disorders, 2023
The capillary hemangioma shows a lobulated tumor composed of capillary size vascular channels or solid clusters of proliferating endothelial cells (Figure 25.13). The stroma separating the vascular channels shows edema and myxoid changes. Few larger feeder vessels may be seen in between the lobules. The endothelial cells of hemangiomas can be outlined by immunostaining with CD31.
Imaging in nail diseases
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Kalpana Bhatt, Swagata Arvind Tambe, Hemangi R. Jerajani, Deepak Bhatt, Chitra S. Nayak
Also known as “lobular capillary hemangioma” is a benign vascular proliferation that can arise on the skin or subcutaneous tissue. Periungual PGs can be caused by local trauma, drug intake, or peripheral nerve injury. Clinically it presents as a bright red and rapidly growing mass on the fingertip. Ulceration and bleeding are common complications.
Immunotherapeutic approaches in nasopharyngeal carcinoma
Published in Expert Opinion on Biological Therapy, 2019
James CH Chow, Roger KC Ngan, KM Cheung, William CS Cho
Camrelizumab, a humanized anti-PD-1 antibody, was evaluated in two phase I trials in China [57]. In the first study, camrelizumab monotherapy was tested in 93 treatment-refractory recurrent or metastatic NPC patients. The safety profile was satisfactory where 16% had grade ≥3 treatment-related adverse events. Capillary hemangioma with hyperproliferative vascular response was a frequent phenomenon observed in 88% of patients. ORR and median PFS were 34% and 5.6 months, respectively. The second trial studied the combination of camrelizumab with gemcitabine-cisplatin in first-line palliative setting. Twenty out of 23 (87%) patients experienced grade ≥3 treatment-related adverse events, most prominent being myelosuppression, edema, and hyponatremia. ORR was high at 91% with a 12-month PFS of 61%. Of note, these two studies were conducted in a region where NPC is endemic, over 80% of the recruited patients had tumors with WHO type II or III histology. Tumor PD-L1 status was not reported. A phase III trial is ongoing to evaluate the role of adjuvant camrelizumab after chemoRT (NCT03427827).
Letter to the Editor Regarding the Article Stop Calling Me Cavernous Hemangioma! A Literature Review on Misdiagnosed Bony Vascular Anomalies
Published in Journal of Investigative Surgery, 2022
Several reports in literature recorded similar cases as Demir et al. [7] who reported, a lesion in a female patient 25 years old stimulated by pregnancy. The lesion was surgically removed and the pathological report confirmed its nature as a capillary hemangioma based on the histological picture. Also, Loftus et al. [8] reported a capillary hemangioma in a 51-year-old man presenting with a swelling in the right forearm. The lesion nature was confirmed also histologically as the previous one.
Retinal arteriolar macroaneurysms with supravalvular pulmonic stenosis in the United Arab Emirates
Published in Ophthalmic Genetics, 2022
Arif O. Khan, Francesco Pichi, Piergiorgio Neri, Emad B. Abboud
Some other pediatric retinal vvascular disorders that RAMSVPS (or Coats disease) may be mistaken for include facioscapulohumeral muscular dystrophy, CTC1-related telomeropathy (Coats plus syndrome), retinitis pigmentosa with vascular abnormalities, Von-Hippel–Lindau disease, and retinal vasculitis. Facioscapulohumeral muscular dystrophy is an autosomal dominant muscular dystrophy that is rarely associated with telangiectasias or exudative retinopathy, which can be bilateral (6). More commonly, the only ophthalmic feature is retinal arteriolar tortuosity. CTC1-related telomeropathy is an autosomal recessive multi-system disease that includes developmental delay, neurological disease, multiple visceral disorders, skeletal anomalies, and skin anomalies (7,8). Bilateral retinal vascular anomalies and capillary telangiectasias lead to exudative retinopathy in affected children, who are overtly syndromic. Retinitis pigmentosa with vascular abnormality is a rare association, and the vascular abnormality can range from telangiectasia with exudation to vasoproliferative tumor (9). While this rare association has been reported with pathogenic variants in certain genes, it can occur in dominant or recessive retinitis pigmentosa from a variety of gene mutations. Von-Hippel–Lindau disease is a systemic autosomal dominant cancer-predisposition syndrome (10). The characteristic retinal capillary hemangioma can be unilateral or bilateral and leak or bleed, leading to exudative retinopathy, neovascularization, or hemorrhage. Retinal vasculitis in the context of inflammation of various causes can lead to aneurysmal dilations and exudative retinopathy with inflammatory signs. IRVAN (idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis) is a rare bilateral condition in otherwise healthy children or young adults for which diagnosis is based on three major criteria (retinal vasculitis, aneurysmal dilations at arterial bifurcations, and neuroretinitis) and three minor criteria (peripheral capillary nonperfusion, retinal neovascularization, and macular exudation) (11).