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Paediatric clinical pharmacology
Published in Evelyne Jacqz-Aigrain, Imti Choonara, Paediatric Clinical Pharmacology, 2021
Evelyne Jacqz-Aigrain, Imti Choonara
Inappropriate formulation of a baby powder containing talc in France resulted in the death of 36 infants and young children. The baby powder contained 6.3% hexachlorophene, which is a known neurotoxin. The affected children developed an encephalopathy; in total 204 children became ill and 36 died [19]. The major formulation errors are highlighted in Table 2.
Evaluating Toxic Tort Cases
Published in Julie Dickinson, Anne Meyer, Karen J. Huff, Deborah A. Wipf, Elizabeth K. Zorn, Kathy G. Ferrell, Lisa Mancuso, Marjorie Berg Pugatch, Joanne Walker, Karen Wilkinson, Legal Nurse Consulting Principles and Practices, 2019
William P. Gavin, Mark A. Love, Wendie A. Howland
Talc is a soft mineral made up mainly of magnesium, silicon, and oxygen. Talcum powder is widely used in cosmetics and baby powder. Chemically, it is similar to asbestos, though it does not come in an asbestiform fiber shape. However, talc is often found near tremolite asbestos.
Acute Lung Injury In Children Due To Chemical And Physical Agents
Published in Lourdes R. Laraya-Cuasay, Walter T. Hughes, Interstitial Lung Diseases in Children, 2019
Hayden and Sproul306 surveyed 100 parents of young infants and found that 69% reported regular use of baby powder, and fewer than one half of users and nonusers were aware of any hazards. Most powder users were using the brand they had received as a sample while in the hospital. Powder users believed that powder was useful in preventing or treating diaper rash.
Evaluation of asbestos exposure resulting from simulated application of spiked talcum powders
Published in Inhalation Toxicology, 2022
Eric W. Miller, Benjamin Roberts, Kara Keeton, Andrew Monnot, Taylor Tarpey, Nicole Zoghby, Alan Segrave, Jennifer S. Pierce
On average 3.11 g (range: 1.95–7.48 g) of spiked cosmetic talc was applied during puff applications compared to 2.98 g (range: 2.06–3.97 g) during shaker applications; this difference was not statistically significant (p = 0.1489). The reported mass of cosmetic talc products used in historical application studies varies considerably (0.03–26.8 g; mean = 5.4 g; n = 100). Specific to adult talcum powder applied with a shaker applicator, Aylott et al. (1979) reported that the mass applied ranged from 2.5 to 12.5 g (n = 24; mean = 7.6 g), Russell et al. (1979) reported that the mass applied ranged from 0.52 to 17.16 g (n = 44; mean = 8.8 g), Anderson et al. (2016) reported that the mass applied ranged from 5.4 to 26.8 g (n = 10; mean = 11.6 g), and Gordon et al. (2014) reported a mass of 0.37 g applied per simulation. Regarding adult talcum powder applied with a puff applicator, Aylott et al. (1979) reported that the mass applied ranged from 0.03 to 0.22 g (n = 12; mean = 0.09), and Gordon et al. (2014) reported a mass of 6.25 g applied per simulation. The amount of spiked cosmetic talc applied in our study is somewhat higher than that reported by the EPA (2.01 g for ‘powders’; 0.8 g for ‘baby powder – adult use’; 0.085 g for ‘face powders’) (EPA 2011).
Response to Roggli et al. (2020) “Talc and mesothelioma: mineral fiber analysis of 65 cases with clinicopathological correlation”
Published in Ultrastructural Pathology, 2020
Triet Tran, David Egilman, Mark Rigler
Srebro et al. (1995) did not collect information on either industrial or cosmetic talc exposure for either cases or the single control that was used to establish a “background” talc lung burden.3 The use of this case is problematic. Case #24 was a male military veteran who died from Alzheimer’s disease whose job and personal history was unknown and unobtainable. Control case #24 had a combined tremolite, actinolite, and anthophyllite (TAA) level.2 Talc is the only commercial product that contains the combination of tremolite and/or anthophyllite and/or actinolite.4 Actinolite is not present in any commercial product apart from talc. J&J estimated that over 200 million babies and parents were exposed to its baby powder during diapering.5 Cosmetic talc body powder exposures can be quite high during normal use and have resulted in fatal cases of talcosis.6 Srebro et al. (1995) did not rule out this or any other potential cosmetic talc exposure.
Incidence and characteristics of acute and overuse injuries in elite powerlifters
Published in Cogent Medicine, 2019
Thomas Reichel, Martin Mitnacht, Annabel Fenwick, Rainer Meffert, Olaf Hoos, Kai Fehske
As data acquisition regarding injuries in this study was done during active participation in competition, there was a significant number of lifters (8.7%) sustaining an acute or overuse injury, in accordance with previous research (Haykowsky & Warburton, 1999; Keogh, Hume, & Pearson, 2006; Raske & Norlin, 2002; Winwood, Hume, Cronin, & Keogh, 2014) Due to longer observation time and the possibly difficult retrospective design the injury incidence of 1.5 per 1,000 h was lower than the mean incidence in most of these already published studies that showed injury incidences ranging from 2,6 to 5,5 per 1000 h (Keogh et al., 2006; Raske & Norlin, 2002; Winwood et al., 2014). Only Siewe et al. reported an even lower incidence with 0,3 per 1000 h in a similar cohort of German powerlifters (Siewe et al., 2011a). Regarding the number of participants, gender distribution, mean age, training- and competitive experience, type and localization of injury and treatment, results were similar to previously published and mentioned research. High incidence of skin lesions, mainly skin abrasions, caused by the wearing of specialized equipment or direct contact of the barbell to the legs during deadlifts was striking. Usage of baby powder or knee long socks conforming to competition rules is an easy way to lessen or abolish these injuries.