China
Africa
Explore chapters and articles related to this topic
Phytomedicines Targeting Antibiotic Resistance through Quorum Sensing and Biofilm Formation Associated with Acne Vulgaris
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Isa A. Lambrechts, Namrita Lall
Acne vulgaris is a disease related to the skin’s pilosebaceous unit that includes the hair shaft, hair follicle and the sebaceous gland that produces sebum. Acne vulgaris predominantly occurs in the torso, back, neck and face. These areas are mostly affected due to the high amount of pilosebaceous units in these sebum-rich areas. These sebum-rich areas are more specifically found in the area between the eyebrows known as the glabella, inside the ear, on the sides of the nostrils and the cheeks, behind the ear and the manubrium that is the upper chest and back. Acne vulgaris is divided into four categories of severity: mild, moderate, moderately severe and severe acne (Williams, Dellavalle, and Garner, 2012; Kaur et al., 2005; Singh, Hatwar, and Nayak, 2011). James (2005) described the severities of acne as follows.
Therapeutic effectiveness
Published in Dinesh Kumar Jain, Homeopathy, 2022
Now it can be said that various skin diseases tend to recover spontaneously which confuses Hahnemann. Herpes zoster spontaneously resolves in three to four weeks, chickenpox in three to four weeks; pityriasis rosea, a papulosquamous disease which recovers in six to seven weeks; pityriasis alba – a kind of eczematous disorder in which children get hypopigmented spots usually disappears after puberty. Acne vulgaris usually disappears after the age of 25 years. Alopecia areata is the commonest cause of patchy hair loss. It is a self-limiting disease. It usually recovers in four to six months. Majority of the cases having infective dermatosis also tend to recover even if no treatment is given. Patients having pyoderma, dermatophyte infection, and candidiasis tend to improve with the onset of winter without any treatment. Herpes simplex usually disappears in one to two weeks but the virus may reactivate again in a few patients. Facial warts may disappear in most of cases without any treatment in three to six months. Molluscum contagiosum can disappear in more than 50% cases without treatment in three to six months.
Acne, rosacea, and similar disorders
Published in Rashmi Sarkar, Anupam Das, Sumit Sethi, Concise Dermatology, 2021
Acne (acne vulgaris) is a disorder in which hair follicles develop, obstructing horny plugs (comedones). Later, inflammation may develop around the obstructed follicles, which can lead to surrounding tissue inflammation also and scar formation.
Ocular surface characteristics in acne vulgaris
Published in Clinical and Experimental Optometry, 2022
Ersin Muhafiz, Murat Öztürk, Remzi Erten
The right eyes of 34 patients (study group) with moderate to severe acne vulgaris and 36 healthy volunteer individuals (control group) were included in this prospective study. The study group was composed of patients with moderate to severe acne vulgaris who presented to the dermatology clinic. None of them had previously received isotretinoin treatment. Many large papules and pustules in addition comedones were classified as moderate acne; nodules and cysts in addition to numerous papules, pustules on the face were classified as severe acne.16 Control group participants consisted of hospital staff and healthy individuals, except for refractive errors, who applied to the ophthalmology clinic. Patients with Sjogren’s syndrome, seborrhoeic dermatitis, acne rosacea or atopic dermatitis, which may affect the ocular surface, were not included in the study. Those that used topical or systemic drugs, those with ocular surface disease, those that wore contact lenses, and those that applied makeup on their eyelids or lashes were excluded. The control group consisted of healthy volunteers from a similar age group.
The impact of active vitamin D administration on the clinical outcomes of acne vulgaris
Published in Journal of Dermatological Treatment, 2021
Amal Ahmed Mohamed, Eman Mohamed Salah Ahmed, Rasha T.A. Abdel-Aziz, Halaa H. Eldeeb Abdallah, Hadeel El-Hanafi, Ghada Hussein, Maggie M. Abbassi, Radwa El Borolossy
There are many identified pathological factors that determine the occurrence of acne vulgaris. Among these factors are the disorder of hair follicle keratosis, colonization by Propionibacterium acnes (P. acnes), overproduction and changes in a composition of sebum (2). All these factors lead to the formation of microcomedones – a composition of accumulated un-exfoliated corneocytes obstructing the follicle ostium, subsequently leading to bacterial colonization and inflammation (3). Moreover, recent studies highlighted the role of inflammation as one of the earliest and the most important pathophysiological phenomena in acne (4,5). In subclinical lesions, lymphocytes and macrophages start to accumulate and produce multiple pro-inflammatory cytokines – interleukins: IL-1, IL-6, IL-8, IL-10, IL-12 and tumor necrosis factor – TNF-α. These molecules, in addition to activation of inflammation, stimulate keratinocytes proliferation and reconstruction of a surrounding connective tissue (6).
Peptidomic analysis in the discovery of therapeutically valuable peptides in amphibian skin secretions
Published in Expert Review of Proteomics, 2019
J. Michael Conlon, Milena Mechkarska, Jérôme Leprince
The pathogenesis of acne vulgaris is multifactorial involving infection of the pilosebaceous unit with Propionibacterium acnes and a cytokine-mediated inflammatory response. Brevinin-2GUb from H. guentheri [85], and B2RP-ERa from H. erythraea [84], chosen for their low hemolytic activity against human erythrocytes, potently inhibited the growth of clinical isolates of P. acnes and reduced production of the proinflammatory cytokine TNF-α by concanavalin A-stimulated human peripheral blood mononuclear cells. Production of the anti-inflammatory cytokines TGF-β, IL-4, and IL-10 by both unstimulated and concanavalin A-stimulated cells was significantly increased by B2RP-ERa treatment [111]. A possible therapeutic role in the treatment of acne vulgaris was thereby suggested.