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The who, what, where, when, why and how of picking, pulling and biting behaviors
Published in Stacy K. Nakell, Treatment for Body-Focused Repetitive Behaviors, 2023
Women tend to notice fluctuations in BFRBs along with their menstrual cycles throughout life. During middle school and high school, acne is a common development, and pimples are there to be picked, easily becoming a focus of self-consciousness. At a time when belonging is a key developmental task, the sense of difference caused by obvious skin and hair damage increases social isolation. Preteens and teens may be less interested than their parents in working on their BFRBs and helping them to identify an internal motivation for change will be key to treatment.
Acne Vulgaris
Published in Charles Theisler, Adjuvant Medical Care, 2023
Acne vulgaris is the most prevalent chronic skin disease in the U.S. It is the most common chronic skin disorder among the adolescent age group, affecting 90%–95% of the midteen population. Acne also affects young adults and can persist into the 30s and 40s.1 It is characterized by areas of pimples (e.g., blackheads, whiteheads, pustules, cysts, etc.), greasy skin, and possible scarring. Acne is primarily thought to be due to overactivity of the sebaceous (oil) glands in the skin where sebum and dead skin block pores and become inflamed. Outbreaks tend to occur where sebaceous glands are most numerous on the face and upper chest, back, or shoulders. Complications include scarring, cutaneous abscesses, and acneiform lesions.
Malignant Neoplasms
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Mark Biro, Vesna Petronic-Rosic
Clinical presentation: BCC is found in areas of sun exposure, such as the head and neck region, chest, back, and forearms (Figure 21.1, Table 21.1). Typically, patients will describe a slow growing, pimple that will not pop or a wound not healing with time.
Effects and safety of fire needle adjuvant chemical peels therapy in acne vulgaris: a systematic review and meta-analysis
Published in Journal of Dermatological Treatment, 2023
Jianfeng Zhang, Peng Lin, Chenqi Guo, Cong Ma, Yiting Liu, Yingdong Wang, Yu Zhang
Two studies (31,34) reported skin lesions, one including comedones, pimples, and pustules, and the other involving comedones and pimples. Considering the significant heterogeneity (I2 = 86%, p < 0.00001), we adopted a random-effects model. The experimental group had better performance in reducing skin lesions than the control group (MD = −2.11, 95% CI [−2.74, −1.47], p < 0.00001). Subgroup analysis was performed according to different skin lesions. As a result, the numbers of comedones, pimples, and pustules of experimental group after treatment decreased compared with control, with significant differences (MD = −2.26, 95% CI [−3.78, −0.74], p = 0.004; MD = −2.62, 95% CI [−5.17, −0.06], p = 0.04; MD = −1.49, 95% CI [−2.15, −0.83], p < 0.00001) (Figure 7).
Thermosensitive gel based on cellulose derivative for topical delivery of propolis in acne treatment
Published in Pharmaceutical Development and Technology, 2022
Fernanda Belincanta Borghi-Pangoni, Jéssica Bassi da Silva, Rafaela Said dos Santos, Ana Paula Trevisan, Francyelle Carolyne de Castro Hott, Marcelly Chue Gonçalves, Renata Katsuko Takayama Kobayashi, Maria Vitória Felipe de Souza, Marcia Edilaine Lopes Consolaro, Lidiane Vizioli de Castro-Hoshino, Mauro Luciano Baesso, Marcos Luciano Bruschi
Acne vulgaris is among the two main skin disorders globally, and it is the 8th in prevalence (Garg 2016; Taleb et al. 2018; Mancuso et al. 2020). This dermatological disease occurs on the upper back, neck region, chest, and mainly on the face, and it can lead to social and psychological problems for the patient. It is characterized by abnormal sebum secretion, with bacterial growth, inflammation, follicular epithelial desquamation, and immunological responses of the host (Castro et al. 2011; Patel and Prabhu 2020). The proliferation of microorganisms like Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, is considered one of many factors that can induce the inflammatory process (Gollnick et al. 2003; Bojar and Holland 2004; Barbosa et al. 2014; Mazzarello et al. 2018). Acne can be classified into mild (comedones and pimples without inflammation), moderate (presence of papules, pustules, and some inflammation), and severe with the presence of previous characteristics and painful cystic nodules, which can form skin scars (Jacob et al. 2001; Patel and Prabhu 2020).
Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells
Published in Journal of Microencapsulation, 2021
Reyhan Dilsu Colpan, Aysegul Erdemir
The percentage of cumulative release of quercetin and CAPE molecules in the QuCaNP-3 was shown at pH 7.4 and pH 5.5 in Figure 2(a,b), respectively. As it is shown in Figure 2(a), both quercetin and CAPE in QuCaNP-3 exhibits controlled release characteristics on the contrary of free molecules. In addition, the percentage of release in the early days constituted the highest percentage of the release and this effect called ‘burst effect’ in the literature. After the burst effect, a slower and controlled release occurred. On the 7th day, 36.59% (w/w) and 55.56% (w/w)of release observed for quercetin and CAPE molecules, respectively. At the end of the 30-day period, quercetin release rate in the QuCaNP-3 formulation was peaked at 47.19% (w/w) while CAPE release in the QuCaNP-3 was peaked at 63% (w/w) (Figure 2(a)). The release profiles showed that quercetin and CAPE loaded nanoparticles released slowly and in a controlled manner consistent with literature (Pool et al. 2012, Arasoglu et al. 2016). Also, similar results were reported in a study by Pimple et al which quercetin and etopside were encapsulated into PLGA nanoparticles for combination therapy in cancer (Pimple et al. 2012).