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Rosacea/Acne Rosacea
Published in Charles Theisler, Adjuvant Medical Care, 2023
The anti-inflammatory and antioxidant actions of zinc have also been utilized for the management of other follicular occlusion disorders like hidradenitis suppurativa, acne conglobata, and folliculitis decalvans. Brocard et al. observed clinical response without significant side effects in all 22 patients of hidradenitis suppurativa when treated with zinc gluconate 90 mg/day.6 Similarly, Kobayashi et al. reported complete cure of acne conglobata and dissecting cellulitis with oral zinc sulphate.7 However, the overall benefit of zinc in these disorders remains understudied.8
Adnexal Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Hasan Aksoy, Jordan V. Wang, Ayşe Serap Karadağ
Acne conglobata is a severe form of acne presenting with numerous inflamed papules, grouped comedones, painful nodules, cysts, sinus tracts, and severe scars, which predominantly involve the face and trunk. Acne conglobata is a component of the follicular occlusion tetrad, which is also composed of hidradenitis suppurativa, dissecting cellulitis of the scalp, and pilonidal sinus.
Acne
Published in Samar Razaq, Difficult Cases in Primary Care, 2021
Acne is characterised by the presence of comedones, which are non-inflammatory follicular lesions. The follicle may be open (blackheads) or closed (whiteheads). They may be the only lesions present or may be accompanied by inflamed papules, cysts and pustules. The more severe the acne, the larger, deeper and more inflamed are the lesions. In severe cases deep nodular lesions may develop that are filled with mucopurulent material and are more likely to scar. In a rare form of acne, acne conglobata, these nodules may interconnect and require drainage, resulting in an exceptionally severe form of disease.
Clascoterone cream (1%) topical androgen receptor inhibitor for the treatment of acne in patients 12 years and older
Published in Expert Review of Clinical Immunology, 2021
Nine subjects experienced AEs that led to discontinuation including moderate application site swelling, moderate application site dryness, moderate acne cystic, moderate application site acne, moderate acne conglobata, moderate acne, mild polycystic ovaries, severe suicide attempt, and moderate hair color changes. Clascoterone cream-related AEs (n = 19) were mild sunburn, moderate application site swelling, moderate application site pruritus, moderate application site erythema, mild or moderate application site dryness, mild or moderate application site acne, mild or moderate application site pain, mild dysgeusia, moderate acne (for each, n = 2), moderate cystic acne, moderate acne conglobata, mild contact dermatitis, severe pruritus, and moderate hair color changes. There were no systemic events or any differences between genders.
Pamidronate in chronic non-bacterial osteomyelitis: a randomized, double-blinded, placebo-controlled pilot trial
Published in Scandinavian Journal of Rheumatology, 2020
CM Andreasen, AG Jurik, BW Deleuran, HC Horn, TB Folkmar, T Herlin, EM Hauge
CNO is characterized by chronic and relapsing episodes of osteoarticular inflammation. Clinically, patients present with musculoskeletal complaints such as pain, tenderness, and swelling referable to the involved skeletal sites. CNO is often associated with skin eruptions such as palmoplantar pustulosis and acne conglobata, but also synovitis (3, 4, 7). Bone lesions in adults are predominantly sited in the anterior chest wall (ACW), the spine, and the pelvis (3, 8). In children, bone lesions have a predilection for the metaphysis of the lower extremities, the spine, the pelvis, and the clavicles (9, 10). Imaging features are characteristic in the form of osteitis and hyperostosis. Whole-body magnetic resonance imaging (WBMRI) enables assessment of the overall status of bone inflammation and is increasingly used in CRMO and in both arthritis and SpA (11–13).
Emerging drugs for the treatment of hidradenitis suppurativa
Published in Expert Opinion on Emerging Drugs, 2020
Alecia S Folkes, Faris Z Hawatmeh, Alan Wong, Francisco A Kerdel
Fluorescent light energy (FLE) is a noninvasive therapeutic mechanism that induces photobiomodulation (PBM) and has recently been seen to play a beneficial role in treating HS and other inflammatory diseases such as acne conglobata [12]. PBM has both antibacterial and anti-inflammatory effects [12]. In vitro-studies show that FLE decreases pro-inflammatory cytokines, in particular TNF- a and IL-6, resulting in decrease response of human epidermal keratinocytes and human dermal fibroblasts [12]. This plays an essential role in regulating immune responses in inflammatory conditions [12]. FLE has been found to not only help in resolving active lesions but also decreases associated redness [12]. There has been an observed increase in collagen production aiding in healing of the skin lesions and improving not only the appearance of scars, but overall appearance of the skin [12]. Not much research has been done on the overall efficacy of FLE, but should be considered as a potential treatment option [12].